INT62887

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Context Info
Confidence 0.14
First Reported 1995
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0.95
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ITPR3) small molecule metabolic process (ITPR3) endoplasmic reticulum (ITPR3)
transmembrane transport (ITPR3) cytoplasm (ITPR3) signal transduction (ITPR3)
Anatomy Link Frequency
nervous system 2
nose 2
ITPR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 6 97.40 Very High Very High Very High
bradykinin 7 96.68 Very High Very High Very High
Enkephalin 3 95.72 Very High Very High Very High
agonist 169 92.72 High High
Serotonin 3 68.92 Quite High
Opioid 1 56.56 Quite High
imagery 6 43.36 Quite Low
Pain 6 32.04 Quite Low
qutenza 3 26.36 Quite Low
nociceptor 9 22.88 Low Low
Disease Link Frequency Relevance Heat
Helminth Infection 42 95.00 High High
Sprains And Strains 27 89.20 High High
Neuroblastoma 1 75.00 Quite High
Targeted Disruption 6 59.68 Quite High
Stress 4 58.52 Quite High
Loss Of Sense Of Smell 3 38.28 Quite Low
Pain 6 32.04 Quite Low
Nociception 3 11.40 Low Low
Arterial-venous Cerebral Malformations 3 5.64 Low Low
Heart Rate Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For some of these functions, we have some insights into the nature of events upstream of itr-1 and in particular into the member(s) of the phospholipase C (PLC) family responsible for IP3 production (Figure 1A).
Regulation (responsible) of Gene_expression (production) of IP3
1) Confidence 0.14 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0.06 Pain Relevance 0
When leu-EK was concomitantly added with carbachol, an additive effect was observed in IP3 generation.
Regulation (effect) of Gene_expression (generation) of IP3
2) Confidence 0.14 Published 1995 Journal Chin J Physiol Section Abstract Doc Link 8697901 Disease Relevance 0.07 Pain Relevance 0.44
As Figure 2A shows, when cDNA encoding the IP3 super sponge is expressed under the control of the unc-119 promoter, the reversal response to nose touch is severely disrupted, while expression of the control sponge in the same way has no effect.
Regulation (under) of Gene_expression (expressed) of IP3 in nose
3) Confidence 0.09 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0.44 Pain Relevance 0.05
In order to investigate the role of IP3 signalling in the nervous system, we expressed the cDNA encoding the IP3 binding domain of itr-1 (an “IP3 sponge”, [20]) under the control of the promoter of unc-119, which is widely, and exclusively, expressed in the nervous system [25].
Regulation (under) of Gene_expression (expressed) of IP3 in nervous system
4) Confidence 0.09 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0.32 Pain Relevance 0.03
To determine basal IP3 levels, an equivalent volume (50 ?
Spec (determine) Regulation (determine) of Spec (determine) Gene_expression (levels) of IP3
5) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.10
following its secondary restimulation (Fig. 2G, p = 0.0049), it had no significant effect on IP3 generation by TP?
Neg (no) Regulation (effect) of Gene_expression (generation) of IP3
6) Confidence 0.02 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0.06 Pain Relevance 0.14

General Comments

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