INT62895

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 51
Total Number 53
Disease Relevance 28.80
Pain Relevance 10.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOSTRIN) cytoplasmic membrane-bounded vesicle (NOSTRIN) plasma membrane (NOSTRIN)
cytoskeleton (NOSTRIN) cytoplasm (NOSTRIN)
Anatomy Link Frequency
endothelial cells 5
endometrium 4
neuronal 3
endothelium 2
macrophages 1
NOSTRIN (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 8 100.00 Very High Very High Very High
Somatostatin 7 100.00 Very High Very High Very High
Neuropeptide 6 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 3 100.00 Very High Very High Very High
endometriosis 176 99.92 Very High Very High Very High
Calcitonin gene-related peptide 10 99.80 Very High Very High Very High
cOX1 1 99.80 Very High Very High Very High
cytokine 224 99.76 Very High Very High Very High
metalloproteinase 26 99.64 Very High Very High Very High
Paracetamol 12 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 209 99.92 Very High Very High Very High
Chronic Renal Failure 135 99.92 Very High Very High Very High
Amyloid Plaque 4 99.78 Very High Very High Very High
Cancer 126 99.68 Very High Very High Very High
Shock 18 99.32 Very High Very High Very High
INFLAMMATION 523 99.00 Very High Very High Very High
Necrosis 65 98.72 Very High Very High Very High
Cardiovascular Disease 87 98.44 Very High Very High Very High
Apoptosis 237 98.28 Very High Very High Very High
Disorder Of Lipid Metabolism 53 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We showed that the excitotoxin-induced microglia reaction, the expression of inducible nitric oxide synthase-positive cells and the production of interleukin-1beta and prostaglandin-E2 in the injected area were attenuated by the NO-flurbiprofen (15 mg/kg, p.o.) treatment.
Gene_expression (expression) of nitric oxide synthase-positive in microglia
1) Confidence 0.75 Published 2001 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11459126 Disease Relevance 0.60 Pain Relevance 0.21
Ketamine reduces nitric oxide biosynthesis in human umbilical vein endothelial cells by down-regulating endothelial nitric oxide synthase expression and intracellular calcium levels.
Gene_expression (expression) of nitric oxide synthase in endothelial cells associated with ketamine
2) Confidence 0.73 Published 2005 Journal Crit. Care Med. Section Title Doc Link 15891334 Disease Relevance 0 Pain Relevance 0.24
Immunoblot analysis revealed that ketamine time-dependently decreased endothelial NO synthase protein production in human umbilical vein endothelial cells.
Gene_expression (production) of endothelial NO synthase protein in umbilical vein
3) Confidence 0.73 Published 2005 Journal Crit. Care Med. Section Body Doc Link 15891334 Disease Relevance 0 Pain Relevance 0
The exaggerated expression of endothelial nitric oxide synthase in the endometrium throughout the cycle suggests some pathologic role in endometriosis and adenomyosis.


Gene_expression (expression) of endothelial nitric oxide synthase in endometrium
4) Confidence 0.68 Published 1998 Journal Fertil. Steril. Section Body Doc Link 9496346 Disease Relevance 0 Pain Relevance 0
RESULT(S): The analyses revealed phase-dependent changes in the expression of endothelial nitric oxide synthase in the surface and glandular epithelia during the menstrual cycle in the fertile controls.
Gene_expression (expression) of endothelial nitric oxide synthase
5) Confidence 0.68 Published 1998 Journal Fertil. Steril. Section Body Doc Link 9496346 Disease Relevance 0.16 Pain Relevance 0
Contrary to expectations, the expression of endothelial nitric oxide synthase in endometriosis and adenomyosis was persistently greater than the control levels throughout the menstrual cycle.
Gene_expression (expression) of endothelial nitric oxide synthase
6) Confidence 0.68 Published 1998 Journal Fertil. Steril. Section Body Doc Link 9496346 Disease Relevance 0.12 Pain Relevance 0
OBJECTIVE: To determine the expression of endothelial nitric oxide synthase in the endometrium during the menstrual cycle in endometriosis and adenomyosis.
Spec (determine) Gene_expression (expression) of endothelial nitric oxide synthase in endometrium associated with endometriosis and dismenorea
7) Confidence 0.68 Published 1998 Journal Fertil. Steril. Section Abstract Doc Link 9496346 Disease Relevance 0.35 Pain Relevance 0.26
This model has predicted efficacy of nitric oxide synthase inhibition and calcitonin gene-related peptide receptor blockade.
Neg (inhibition) Gene_expression (inhibition) of nitric oxide synthase associated with calcitonin gene-related peptide
8) Confidence 0.65 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19250288 Disease Relevance 0.53 Pain Relevance 0.58
The expression of neuropeptides, and the enzymes nitric oxide synthase and tyrosine hydroxylase were examined in intramural ganglia of human urinary bladder using single label immunocytochemistry.
Spec (examined) Gene_expression (expression) of nitric oxide synthase in urinary bladder associated with neuropeptide
9) Confidence 0.62 Published 1996 Journal J. Neurocytol. Section Abstract Doc Link 8699193 Disease Relevance 0 Pain Relevance 0.19
Endothelial nitric oxide synthase (eNOS) gene expression was increased by 67% ± 19% (p = 0.002) and 66% ± 16% (p = 0.039) in the CR and CREX groups, respectively (Figure 1D).
Gene_expression (expression) of Endothelial nitric oxide synthase
10) Confidence 0.35 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.08 Pain Relevance 0
Western blot analysis showed the presence of a constitutive endothelial nitric oxide synthase in the urothelial layer, suggesting that urothelium may release nitric oxide in response to electrical field stimulation and that this release is blocked by tetrodotoxin.
Gene_expression (presence) of endothelial nitric oxide synthase associated with tetrodotoxin
11) Confidence 0.31 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082269 Disease Relevance 0.25 Pain Relevance 0.18
Differential expression of nitric oxide synthase (eNOS) in senescent endothelial cells has also been identified by Bernardini et al. [53].
Gene_expression (expression) of nitric oxide synthase in endothelial cells
12) Confidence 0.31 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.27 Pain Relevance 0
Curcumin inhibition of endothelial nitric oxide synthase (eNOS) expression in endothelial cells has been shown to contribute to impaired endothelial tube formation.39 Taken together, our results suggest that the antiangiogenic activity of curcumin involves modulation of multiple pathways in endothelial cells.
Gene_expression (expression) of endothelial nitric oxide synthase in tube
13) Confidence 0.23 Published 2008 Journal Gut Section Body Doc Link PMC2582343 Disease Relevance 0.67 Pain Relevance 0.20
In endothelial cells, it increases intracellular calcium stimulating the production of nitric oxide through the expression of the endothelial nitric oxide synthase enzyme.
Gene_expression (expression) of nitric oxide synthase in endothelial cells
14) Confidence 0.21 Published 2010 Journal International Journal of Vascular Medicine Section Abstract Doc Link PMC3003984 Disease Relevance 0.25 Pain Relevance 0.04
PLC-induced dilatative adaptation, and growth was found associated with increased inducible nitric oxide synthase and reduced arterial vascular endothelial growth factor and intracellular adhesion molecule-1 expression.
Gene_expression (expression) of nitric oxide synthase
15) Confidence 0.19 Published 2010 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 20056909 Disease Relevance 0.07 Pain Relevance 0
PLC increased endothelial and human umbilical vascular endothelial cell proliferation and rapidly reduced inducible nitric oxide synthase and NADPH-oxidase 4-mediated reactive oxygen species production in human umbilical vascular endothelial cells; NADPH-oxidase 4 also regulated NF-kappaB-independent intracellular adhesion molecule-1 expression.
Gene_expression (production) of nitric oxide synthase in endothelial cell
16) Confidence 0.17 Published 2010 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 20056909 Disease Relevance 0.05 Pain Relevance 0
The Western blot analysis on human umbilical vein endothelial cells indicated that VOA increased the expression of endothelium nitric oxide synthase.
Gene_expression (expression) of nitric oxide synthase in endothelium
17) Confidence 0.16 Published 2003 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 14508237 Disease Relevance 0.11 Pain Relevance 0.24
Expression of endothelial NO synthase in the endometrium of patients with endometriosis or adenomyosis is persistently marked throughout the menstrual cycle [132].
Gene_expression (Expression) of endothelial NO synthase in endometrium associated with endometriosis and dismenorea
18) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 1.26 Pain Relevance 0.68
Increased expression of endothelial NO synthase has been reported throughout the menstrual cycle in the endometrium of women with endometriosis [139].

2.11 Nitric oxide synthase and the ovary

Gene_expression (expression) of endothelial NO synthase in endometrium associated with endometriosis
19) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.63 Pain Relevance 0.43
Endothelial NO synthase is expressed in thecal cells, granulosa cells, and the surface of oocyte during the follicular development.
Gene_expression (expressed) of Endothelial NO synthase in oocyte
20) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.31 Pain Relevance 0.10

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