INT629

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Context Info
Confidence 0.45
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.79
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PGC) extracellular space (PGC) extracellular region (PGC)
nucleolus (PGC) nucleus (PGC)
Anatomy Link Frequency
pituitary 2
stomach 2
PGC (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 1 100.00 Very High Very High Very High
peptic ulcer disease 9 98.68 Very High Very High Very High
Potency 2 96.64 Very High Very High Very High
Somatostatin 11 96.14 Very High Very High Very High
antagonist 3 91.92 High High
headache 5 89.20 High High
Analgesic 2 80.68 Quite High
Inflammation 12 80.24 Quite High
cINOD 35 69.52 Quite High
Neuropeptide 2 55.28 Quite High
Disease Link Frequency Relevance Heat
Duodenal Ulcer 5 98.90 Very High Very High Very High
Injury 24 98.80 Very High Very High Very High
Ulcers 31 98.68 Very High Very High Very High
Disease 14 98.16 Very High Very High Very High
Peptic Ulcer 13 96.76 Very High Very High Very High
Gastrointestinal Disease 2 94.40 High High
Stress 6 93.88 High High
Nicotine Addiction 1 93.80 High High
Volume Depletion And Dehydration 5 93.16 High High
Syndrome 2 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In healthy volunteers oral administration of human synthetic CT (H-CT) led to reduction in basal and pentagastrin-stimulated acid and pepsin secretion by about 50%, lasting for more than 2 hours after the instillation of CT.
Negative_regulation (reduction) of Localization (secretion) of pepsin
1) Confidence 0.45 Published 1976 Journal Z Gastroenterol Verh Section Abstract Doc Link 64056 Disease Relevance 0.59 Pain Relevance 0.24
Using a 12-hour infusion of salmon synthetic calcitonin (S-CT), distinct and sustained inhibition of gastric acid and pepsin secretion has been demonstrated in 4 normal subjects, 3 patients with peptic ulcer disease and 3 high risk patients.
Negative_regulation (inhibition) of Localization (secretion) of pepsin associated with peptic ulcer disease and disease
2) Confidence 0.45 Published 1976 Journal Z Gastroenterol Verh Section Abstract Doc Link 64056 Disease Relevance 0.47 Pain Relevance 0.15
The drug also reduces the secretion of pepsin, another 'aggressive' factor in peptic ulcer disease.
Negative_regulation (reduces) of Localization (secretion) of pepsin associated with peptic ulcer disease and disease
3) Confidence 0.18 Published 1987 Journal Drugs Section Abstract Doc Link 3121276 Disease Relevance 0.78 Pain Relevance 0.29
Octreotide has effects similar to those of somatostatin but with greater potency and longer duration of action; these effects include inhibition of pituitary release of growth hormone and thyrotropin, inhibition of glucagon or insulin release, and inhibition of the secretion of various gastrointestinal tract hormones (e.g. serotonin, pepsin, gastrin, secretin, motilin, vasoactive intestinal peptide and pancreatic peptides) [9,10].
Negative_regulation (inhibition) of Localization (secretion) of pepsin in pituitary associated with somatostatin, serotonin and potency
4) Confidence 0.03 Published 2005 Journal Crit Care Section Body Doc Link PMC1414034 Disease Relevance 0.62 Pain Relevance 0.26
1) In chronic gastric ulcer bed rest, leaving out smoking and carbenoxolone have increased the rate of healing. 2) In chronic duodenal ulcer it has yet to be shown that any medical measure so far significantly altered the course of the disease. 3) The surgical approach to the treatment of chronic duodenal ulcer is based upon three principles, all of them aiming at reducing the acid-pepsin secretion: a) Removal of the acid secreting mucosa decreases the acid secretory capacity of the stomach; b) Removal of the pyloric antrum eliminates the main source of gastrin, the major known humoral excitant of acid secretion; c) Section of the vagi probably renders the acid secreting cells less responsive to humoral stimulation (Brooks).
Negative_regulation (reducing) of Localization (secretion) of acid-pepsin in stomach associated with nicotine addiction, duodenal ulcer, disease and peptic ulcer
5) Confidence 0.02 Published 1976 Journal Klin. Wochenschr. Section Abstract Doc Link 979073 Disease Relevance 0.70 Pain Relevance 0.07
The mechanism of antiulcer effect could either be due to decrease in acid-pepsin secretion and augmentation of mucin secretion as observed with ethanol extract, while petroleum ether extract might be producing the effect by virtue of its anti-stress activity.
Negative_regulation (decrease) of Localization (secretion) of acid-pepsin associated with stress
6) Confidence 0.02 Published 1997 Journal Indian J. Exp. Biol. Section Abstract Doc Link 9475056 Disease Relevance 0.50 Pain Relevance 0.16
The fulvic acid and 4-methoxy 6-carbomethoxybiphenyl present in Shilajit decrease acid-pepsin secretion, cell shedding, and also act as ulcer protectives.[4041] Thus, Shilajit can be very useful to cope with common high-altitude problems like gastrointestinal disorders and dehydration.


Negative_regulation (decrease) of Localization (secretion) of acid-pepsin associated with gastrointestinal disease, volume depletion and dehydration and ulcers
7) Confidence 0.01 Published 2010 Journal International Journal of Ayurveda Research Section Body Doc Link PMC2876922 Disease Relevance 1.36 Pain Relevance 0
Since rebamipide does not inhibit gastric acid or pepsin secretion [15], it may prevent gastric injury by affecting the gastric mucosal defense system.
Negative_regulation (inhibit) of Localization (secretion) of pepsin associated with injury
8) Confidence 0.00 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2459250 Disease Relevance 0.78 Pain Relevance 0.15

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