INT62901

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.66
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd1a) endoplasmic reticulum (Drd1a) plasma membrane (Drd1a)
nucleus (Drd1a) intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
striatum 6
neurons 2
Drd1a (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 30 100.00 Very High Very High Very High
Dopamine 583 99.24 Very High Very High Very High
Substantia nigra 40 99.24 Very High Very High Very High
Morphine 5 96.40 Very High Very High Very High
Enkephalin 10 85.84 High High
narcan 2 85.28 High High
Neurotransmitter 5 85.24 High High
Eae 35 85.00 Quite High
Nucleus accumbens 5 76.40 Quite High
opioid receptor 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 1 87.84 High High
Disease 25 81.92 Quite High
Targeted Disruption 30 64.84 Quite High
Apoptosis 50 59.72 Quite High
Death 45 58.64 Quite High
Drug Dependence 5 58.20 Quite High
Injury 5 33.36 Quite Low
Cancer 35 5.00 Very Low Very Low Very Low
Hypertrophy 15 5.00 Very Low Very Low Very Low
Macrocephaly 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While no changes in DA release or uptake could be detected by microdialysis, KO animals showed a significant increase in total DA tissue content in dorsal striatum, an effect accompanied by a significant increase in striatal prodynorphin and DRD1 mRNA expression levels.
Positive_regulation (increase) of Gene_expression (expression) of DRD1 mRNA in striatum associated with dopamine
1) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.12 Pain Relevance 0.61
Increased DRD1 and dynorphin levels in medium spiny neurons may enhance the inhibition of DA neurons in the SNc, thereby normalizing overall DA release in the striatum.


Positive_regulation (Increased) of Gene_expression (levels) of DRD1 in striatum associated with dopamine and dynorphin
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.08 Pain Relevance 0.40
However, DRD1 and PDyn mRNA levels were significantly elevated in striatonigral projecting neurons.
Positive_regulation (elevated) of Gene_expression (levels) of DRD1 in neurons
3) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.30 Pain Relevance 0.51
Increased DRD1 and dynorphin levels in medium spiny neurons may enhance the inhibition of DA neurons in the SNc, thereby normalizing overall DA release in the striatum.


Spec (may) Positive_regulation (enhance) of Gene_expression (levels) of DRD1 in striatum associated with dopamine and dynorphin
4) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.08 Pain Relevance 0.40
DRD1 and PDyn mRNA levels were significantly upregulated in KO animals as compared to controls (Fig. 5A and B).
Positive_regulation (upregulated) of Gene_expression (levels) of DRD1
5) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.54
We also expressed the adenylyl cyclases in cells that were transfected with D1A receptor and G beta 1 and G gamma 2 cDNAs.
Positive_regulation (transfected) of Gene_expression (transfected) of D1A receptor
6) Confidence 0.01 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8700117 Disease Relevance 0.09 Pain Relevance 0.89

General Comments

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