INT62916

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 3.25
Pain Relevance 5.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1F) signal transducer activity (HTR1F)
Anatomy Link Frequency
blood vessels 2
vesicle 1
ganglia 1
Dorsal root ganglion 1
neural 1
HTR1F (Homo sapiens)
Pain Link Frequency Relevance Heat
Sumatriptan 17 100.00 Very High Very High Very High
adenocard 7 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
dorsal root ganglion 3 99.54 Very High Very High Very High
agonist 13 99.16 Very High Very High Very High
trigeminal ganglion 4 99.08 Very High Very High Very High
Potency 2 98.92 Very High Very High Very High
Inflammation 47 98.20 Very High Very High Very High
headache 8 97.40 Very High Very High Very High
Migraine 25 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 99.54 Very High Very High Very High
Genetic Predisposition To Disease 1 98.44 Very High Very High Very High
Neurogenic Inflammation 4 98.20 Very High Very High Very High
Headache 32 97.40 Very High Very High Very High
Migraine Without Aura 1 91.88 High High
Nociception 23 91.60 High High
INFLAMMATION 41 83.92 Quite High
Cluster Headache 5 78.00 Quite High
Stress 3 74.88 Quite High
Drug Dependence 1 68.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the high sensitivity of polymerase chain reaction (PCR) amplification, we investigated the expression of the sumatriptan-sensitive 5-HT receptors, namely, the 5-HT1D alpha, 5-HT1D beta, and 5-HT1F subtypes in human trigeminal ganglia (10 experiments) and cerebral blood vessels (seven experiments) obtained postmortem.
Spec (investigated) Gene_expression (expression) of 5-HT1F in blood vessels associated with sumatriptan
1) Confidence 0.75 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8700126 Disease Relevance 0.09 Pain Relevance 0.35
The data confirm that the 5-HT1D beta receptor is the dominant species in human cerebral blood vessels and further show that this receptor and the 5-HT1F are expressed in both neural and vascular tissues.
Gene_expression (expressed) of 5-HT1F in neural
2) Confidence 0.75 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8700126 Disease Relevance 0.15 Pain Relevance 0.26
Expression of the 5-HT1F receptor was detected by gel electrophoresis of the PCR products in six ganglia and by Southern blot hybridization in two additional cases.
Gene_expression (Expression) of 5-HT1F in ganglia
3) Confidence 0.75 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8700126 Disease Relevance 0.07 Pain Relevance 0.31
High affinity (Kd approximately 10 nM) [3H]5-HT binding was detected to membranes obtained from Cos-7 cells transiently expressing the guinea pig 5-HT1F receptor.
Gene_expression (expressing) of 5-HT1F
4) Confidence 0.75 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225282 Disease Relevance 0.33 Pain Relevance 0.49
Isolated microvessels and capillaries consistently expressed messages for the h5-HT1B, h5-HT1D, 5-HT1F, 5-HT2A but not 5-HT7 receptors.
Gene_expression (expressed) of 5-HT1F
5) Confidence 0.75 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10458598 Disease Relevance 0 Pain Relevance 0
In conclusion, our studydoes not provide evidence that the 5HTT, 5-HT1A, 5HT1B,5HT2A and 5HT6 gene polymorphisms play a role in the genetic predisposition to MOH.
Gene_expression (5HTT) of 5HT6 associated with genetic predisposition to disease and headache
6) Confidence 0.65 Published 2010 Journal J Headache Pain Section Abstract Doc Link 19936617 Disease Relevance 0.94 Pain Relevance 1.18
Expression of 5-HT1F and 5-HT2A receptor mRNAs was never detected in any of the microvascular cell cultures.
Gene_expression (Expression) of 5-HT1F
7) Confidence 0.65 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10458598 Disease Relevance 0 Pain Relevance 0.14
When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself.
Gene_expression (transfected) of 5-HT1F associated with agonist and serotonin
8) Confidence 0.65 Published 1997 Journal Life Sci. Section Abstract Doc Link 9395253 Disease Relevance 0.15 Pain Relevance 0.32
The potency of agonists in inhibiting adenylate cyclase in cells transfected with human 5-HT1F receptor was also highly correlated with their potency in the animal model of migraine.
Gene_expression (transfected) of 5-HT1F associated with migraine, agonist and potency
9) Confidence 0.65 Published 1997 Journal Neuroreport Section Abstract Doc Link 9243618 Disease Relevance 0.43 Pain Relevance 0.70
Dorsal root ganglion cells also moderately expressed the 5-HT1F transcripts.
Gene_expression (expressed) of 5-HT1F in Dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
10) Confidence 0.65 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225282 Disease Relevance 0.38 Pain Relevance 0.47
In situ hybridization studies in guinea pig tissue revealed 5-HT1F receptor mRNA expression in the neurons of the trigeminal ganglion, suggesting that the 5-HT1F receptor may play a role in the presynaptic inhibition of neuropeptide release at the level of the intracranial vasculature, thereby blocking the development of neurogenic inflammation.
Gene_expression (expression) of 5-HT1F in vasculature associated with ganglion cysts, inflammation, trigeminal ganglion, neurogenic inflammation and neuropeptide release
11) Confidence 0.65 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225282 Disease Relevance 0.39 Pain Relevance 0.50
We found expression of vesicle fusion and motility genes, ligand- and voltage-gated ion channels, receptor kinases and phosphatases, and, most interestingly, mRNA as well as protein expression of G protein-coupled receptors of neuromediators (corticotropin-releasing hormone 1 [CRH 1] and CRH 2 receptors, orexin/hypocretin 1 and 2 receptors, GABAB receptor, adenosine A(2)B receptor, opioid kappa 1 and mu 1 receptors, and 5-HT 1F receptor).
Gene_expression (expression) of 5-HT 1F in vesicle associated with adenocard and opioid
12) Confidence 0.58 Published 2004 Journal Blood Section Abstract Doc Link 15016651 Disease Relevance 0 Pain Relevance 0.18
The next group of eight genes encodes eight 5-HT serotonergic receptors (5-HT1a, 5-HT1d, 5-HT1e, 5-HT1f, 5-HT2c, 5-HT4, 5-HT5a, and 5-HT6).
Gene_expression (encodes) of 5-HT6
13) Confidence 0.29 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.30 Pain Relevance 0.34

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