INT62917

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Context Info
Confidence 0.60
First Reported 1996
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.18
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1D) signal transducer activity (HTR1D)
Anatomy Link Frequency
trigeminal ganglia 2
neural 2
HTR1D (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 95.52 Very High Very High Very High
Sumatriptan 3 75.00 Quite High
Inflammation 1 74.32 Quite High
Migraine 2 67.92 Quite High
Serotonin 2 50.00 Quite Low
menstrual migraine 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cluster Headache 1 93.16 High High
Stress 1 83.20 Quite High
Menstral Migraine 1 50.00 Quite Low
Headache 2 37.48 Quite Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene expression of 5HT-1B and 5HT-1D receptors in trigeminal ganglia was not regulated by the estrous cycle.
Neg (not) Regulation (regulated) of Gene_expression (expression) of 5HT-1D in trigeminal ganglia
1) Confidence 0.60 Published 2006 Journal Headache Section Body Doc Link 16942467 Disease Relevance 0 Pain Relevance 0
In contrast, the data point to a preferential expression of 5-HT1D alpha receptors in neural versus vascular tissues and strongly reemphasize the need for selective 5-HT1D alpha agonists in the identification of the target tissue(s) for antimigraine drugs.
Regulation (point) of Gene_expression (expression) of 5-HT1D in neural associated with cluster headache and agonist
2) Confidence 0.44 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8700126 Disease Relevance 0.18 Pain Relevance 0.28

General Comments

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