INT62919

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1996
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 5.61
Pain Relevance 9.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gnas) endosome (Gnas) signal transduction (Gnas)
extracellular region (Gnas) plasma membrane (Gnas) GTPase activity (Gnas)
Anatomy Link Frequency
muscle 2
necks 1
neuronal 1
spinal 1
heart 1
Gnas (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 21 100.00 Very High Very High Very High
narcan 6 100.00 Very High Very High Very High
depression 15 99.64 Very High Very High Very High
analgesia 25 99.54 Very High Very High Very High
Intracerebroventricular 2 99.18 Very High Very High Very High
Morphine 29 99.16 Very High Very High Very High
Opioid 7 99.12 Very High Very High Very High
withdrawal 9 98.80 Very High Very High Very High
opioid receptor 9 98.72 Very High Very High Very High
imagery 24 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 72 100.00 Very High Very High Very High
Depression 17 99.64 Very High Very High Very High
Targeted Disruption 101 99.38 Very High Very High Very High
Muscular Dystrophy 87 98.88 Very High Very High Very High
Gastrointestinal Stromal Tumor 76 98.00 Very High Very High Very High
Ovarian Cysts 72 96.44 Very High Very High Very High
Infertility 8 96.00 Very High Very High Very High
Polyostotic Fibrous Dysplasia 18 95.00 High High
Pathologic Processes 1 94.28 High High
Nociception 8 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest a strong genetic contribution to the phenotype in each case, but no mutations in the GNAS1, LHCGR, FSHR, StAR, NR5A1, DMRT4 and NOBOX were found, including DNA extracted from the ovarian cyst tissue in case 9.


Neg (no) Regulation (mutations) of GNAS1 associated with ovarian cysts
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892512 Disease Relevance 0.58 Pain Relevance 0
A familial history of ovarian anomalies was reported in four of the cases reported here also arguing against the involvement of the GNAS1 gene.
Regulation (involvement) of GNAS1
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892512 Disease Relevance 0.78 Pain Relevance 0
Intracerebroventricular administration of oligodeoxynucleotides targeting Gi alpha 2, G(o) alpha, and Gs alpha block supraspinal mu-opioid analgesia, whereas Gi alpha 2 and Gx/z alpha antisense probes block spinal mu analgesia.
Regulation (targeting) of Gs alpha in spinal associated with opioid, intracerebroventricular and analgesia
3) Confidence 0.14 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8700136 Disease Relevance 0 Pain Relevance 1.25
Antisense oligodeoxynucleotides targeting exon 2 of the cloned MOR-1 gene decreased dihydromorphine analgesia and that of its acetylated derivatives, but not morphine analgesia.
Regulation (targeting) of exon associated with morphine and analgesia
4) Confidence 0.03 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15178355 Disease Relevance 0 Pain Relevance 1.79
Twenty micrograms of antisense targeting exons 2 and 3 of the kappa1-opioid receptor significantly reversed the effects of U-50,488H, but antisense targeting exon 1 and mismatch sense did not.
Regulation (targeting) of exon associated with opioid receptor
5) Confidence 0.02 Published 2004 Journal Brain Res. Section Abstract Doc Link 15571673 Disease Relevance 0.08 Pain Relevance 0.55
Antisense studies revealed that probes targeting the second and third coding exon of the orphan clone significantly attenuate OFQ/N analgesia, while the exon 1 probe was inactive.
Regulation (targeting) of exon associated with analgesia
6) Confidence 0.02 Published 1998 Journal Brain Res. Section Abstract Doc Link 9593974 Disease Relevance 0.17 Pain Relevance 1.29
This wide range between studies may be explained by the geographical variability, genetic changes in the tumour tissue (ras-, gsp-,p53- and p21-mutations), accuracy in the clinical and imaging diagnosis of the N0 necks and variability of the extent of neck dissection and pathological processes [20].
Regulation (changes) of gsp in necks associated with pathologic processes, cancer and imagery
7) Confidence 0.01 Published 2011 Journal BMC Cancer Section Body Doc Link PMC3023783 Disease Relevance 0.83 Pain Relevance 0.05
In a recent clinical trial in which exon 51 was targeted, the investigators showed dystrophin expression in the tibialis anterior muscle after one injection of PRO051, a 2L'O-methyl antisense oligonucleotide.20 Although PRO051 and AVI-4658 target the same region of exon 51, we used a phosphorodiamidate morpholino oligomer chemistry, used a longer splice-skipping oligonuceotide, and treated a small intrinsic and relatively non-functional foot muscle, which enabled us to obtain bilateral muscle biopsies that were not available in the PRO051 study.
Regulation (targeted) of exon in muscle
8) Confidence 0.01 Published 2009 Journal Lancet Neurol Section Body Doc Link PMC2755039 Disease Relevance 0 Pain Relevance 0
The rationale for this time frame was taken from previous work in mice and in humans.17,20 In the mdx mouse, the same level of dystrophin expression was detected at 4 weeks as was detected at 2 weeks after an intramuscular injection of a 2L'O-methyl antisense oligonucleotide designed to skip dystrophin exon 23.17 Also, in a study of intramuscular injection of a 2L'O-methyl antisense oligonucleotide that targeted exon 51, given to patients with DMD, the skipped products and dystrophin were still detected in muscles that were analysed 4 weeks after intramuscular injection.20 The area immediately below the needle track was exposed and an open biopsy was taken and rapidly frozen in liquid nitrogen-cooled isopentane, according to standard techniques.29 To ensure that all the injection site had been obtained, most of the EDB muscle was removed.
Regulation (targeted) of exon in muscles associated with muscular dystrophy
9) Confidence 0.01 Published 2009 Journal Lancet Neurol Section Body Doc Link PMC2755039 Disease Relevance 0.15 Pain Relevance 0.05
Nonsense, but not missense mutations, can alter splicing pathways, resulting in failure to include the affected exon in the final mRNA (a phenomenon known as exon skipping).
Regulation (affected) of exon
10) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519029 Disease Relevance 0.12 Pain Relevance 0
Consistent with this possibility, antisense mapping of the MOR-1 clone revealed that M6S analgesia was lowered by probes targeting exon 2 and not by targeting exon 1, a sensitivity profile similar to that of M6G and not morphine.
Neg (not) Regulation (targeting) of exon associated with morphine and analgesia
11) Confidence 0.01 Published 1999 Journal Brain Res. Section Abstract Doc Link 10526089 Disease Relevance 0.08 Pain Relevance 1.43
However, supraspinally only the two antisense probes targeting exon 3 block DPDPE analgesia.
Regulation (targeting) of exon associated with analgesia
12) Confidence 0.01 Published 1997 Journal Brain Res. Section Abstract Doc Link 9125445 Disease Relevance 0 Pain Relevance 0.57
Several SR proteins as well as the RNA binding proteins NAPOR/CUGBP2, hnRNP H, and NOVA2 are thought to positively regulate this exon [19–21].
Regulation (regulate) of exon
13) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.08 Pain Relevance 0
Given its importance to neuronal function, NR1 exon 21 (E21) is a particularly interesting model to study splicing regulation.
Regulation (regulation) of exon in neuronal
14) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.09 Pain Relevance 0
To examine the underlying pathophysiological molecular mechanisms of SD, we analyzed the regulation of eight protein kinase C (PKC) isoforms by immunoblot during SD induced by a high-intensity stimulus of synaptic afferents in the CA1 region of hippocampal slices.
Spec (analyzed) Regulation (regulation) of isoforms associated with kinase c and depression
15) Confidence 0.01 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 9014175 Disease Relevance 0.92 Pain Relevance 0.75
Only the exon 5b sequence was changed to encode the exon 5a amino acids, and the original splicing signals for expression of the downstream exon 5 were kept intact.
Regulation (changed) of exon
16) Confidence 0.00 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.20 Pain Relevance 0
We therefore used the exon 2 ephrin-B2 conditional knockout (Efnb2 CKO) mutant mice and their floxed exon 2 ephrin-B2 (Efnb2fl/fl) littermate controls for further experiments.


Regulation (controls) of exon associated with targeted disruption
17) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.88 Pain Relevance 0.19
However, exon 8a containing mRNA was altered from 1.1 ± 0.5 to 0.3 ± 0.2% of actin).



Regulation (altered) of exon
18) Confidence 0.00 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.20 Pain Relevance 0
Because exon 7 of Gabt4 was identified as a potential Cugbp1 binding site, we investigated if increases in GABT4 expression could be related to misregulation of exon 7 alternative splicing.
Regulation (to misregulat) of exon
19) Confidence 0.00 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.08 Pain Relevance 0.03
Deletions and insertions tend to affect the first part of the exon (especially codons 557 to 559), whereas point muations are limited to just 4 codons (557, 559, 560, and 576) (Corless et al 2004).
Regulation (affect) of exon
20) Confidence 0.00 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.31 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox