INT62920

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Context Info
Confidence 0.52
First Reported 1996
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.08
Pain Relevance 4.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Gnai1) GTPase activity (Gnai1) cytoplasm (Gnai1)
signal transducer activity (Gnai1) signal transduction (Gnai1) nucleus (Gnai1)
Anatomy Link Frequency
spinal 1
striatum 1
Gnai1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 6 100.00 Very High Very High Very High
MU agonist 4 100.00 Very High Very High Very High
nociceptor 2 99.92 Very High Very High Very High
Intracerebroventricular 3 99.18 Very High Very High Very High
Morphine 20 99.04 Very High Very High Very High
analgesia 16 98.80 Very High Very High Very High
Opioid 10 98.08 Very High Very High Very High
Enkephalin 3 96.52 Very High Very High Very High
Analgesic 12 95.04 Very High Very High Very High
mu opioid receptor 1 91.28 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 1 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracerebroventricular administration of oligodeoxynucleotides targeting Gi alpha 2, G(o) alpha, and Gs alpha block supraspinal mu-opioid analgesia, whereas Gi alpha 2 and Gx/z alpha antisense probes block spinal mu analgesia.
Regulation (targeting) of Gi alpha 2 in spinal associated with opioid, intracerebroventricular and analgesia
1) Confidence 0.52 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8700136 Disease Relevance 0 Pain Relevance 1.23
The effects of antisense to Gialpha2 on opioid agonist potency and Gialpha2 protein and mRNA abundance in the mouse.
Regulation (effects) of Gialpha2 associated with mu agonist, nociceptor and potency
2) Confidence 0.41 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9729412 Disease Relevance 0 Pain Relevance 0.83
The subsequent effects on protein levels and mRNA of Gialpha2 were determined in mouse striatum, as well as, the effect on opioid ([d-Ala2, d-Leu5]-enkephalin; DADLE) inhibition of cyclic AMP (cAMP) formation in striatum and morphine analgesic potency.
Regulation (effects) of Gialpha2 in striatum associated with analgesic, enkephalin, opioid, potency and morphine
3) Confidence 0.25 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729412 Disease Relevance 0 Pain Relevance 0.73
Finally, an antisense probe targeting Gi alpha 1 blocks both heroin and morphine-6 beta-glucuronide, but not morphine, analgesia.
Regulation (targeting) of Gi alpha 1 associated with analgesia and morphine
4) Confidence 0.17 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8892377 Disease Relevance 0.08 Pain Relevance 2.00

General Comments

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