INT6293

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Context Info
Confidence 0.78
First Reported 1986
Last Reported 2010
Negated 7
Speculated 13
Reported most in Abstract
Documents 312
Total Number 325
Disease Relevance 48.73
Pain Relevance 215.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
neurons 26
ovary 24
brain 22
spinal cord 13
spinal 9
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 1053 100.00 Very High Very High Very High
Opioid 437 100.00 Very High Very High Very High
Morphine 377 100.00 Very High Very High Very High
mu opioid receptor 356 100.00 Very High Very High Very High
agonist 309 100.00 Very High Very High Very High
Enkephalin 211 100.00 Very High Very High Very High
antagonist 127 100.00 Very High Very High Very High
Analgesic 74 100.00 Very High Very High Very High
analgesia 47 100.00 Very High Very High Very High
gABA 41 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Dependence 9 100.00 Very High Very High Very High
Nociception 69 99.96 Very High Very High Very High
Aids-related Complex 53 99.96 Very High Very High Very High
Squamous Cell Carcinoma 17 99.96 Very High Very High Very High
Injury 46 99.92 Very High Very High Very High
Stress 26 99.92 Very High Very High Very High
Urological Neuroanatomy 71 99.86 Very High Very High Very High
Glioma 15 99.86 Very High Very High Very High
Obesity 16 99.84 Very High Very High Very High
Hyperalgesia 95 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that mu-opioid receptor expression in the rat forebrain is altered by in vivo chronic fluoxetine treatment.
Gene_expression (expression) of mu-opioid receptor in forebrain associated with opioid receptor and fluoxetine
1) Confidence 0.78 Published 1999 Journal Brain Res. Section Abstract Doc Link 9889376 Disease Relevance 0 Pain Relevance 0.53
The effects of long-term dexamethasone on both spinal mu-opioid receptor expression and hyperalgesia during persistent AA inflammation are time dependent.
Gene_expression (expression) of mu-opioid receptor in spinal associated with hyperalgesia, inflammation, opioid receptor, dexamethasone and arthritis
2) Confidence 0.78 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671722 Disease Relevance 1.81 Pain Relevance 1.92
These data suggest that mu-opioid receptor expression in the rat forebrain is altered by in vivo chronic lithium treatment.
Gene_expression (expression) of mu-opioid receptor in forebrain associated with opioid receptor
3) Confidence 0.78 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10670775 Disease Relevance 0 Pain Relevance 0.44
The distribution of cells expressing mu-receptor mRNA and mu-receptor binding sites were compared in brain and spinal cord tissue sections using a combination of in situ hybridization and receptor autoradiographic techniques. mu-Receptor mRNA was visualized with a 35S-labeled cRNA probe directed to transmembrane III-VI of the rat mu-receptor, while mu-receptor binding sites were labeled with the mu-selective ligand [3H]DAMGO.
Gene_expression (expressing) of mu-receptor in brain associated with spinal cord
4) Confidence 0.78 Published 1994 Journal Brain Res. Section Abstract Doc Link 8032920 Disease Relevance 0 Pain Relevance 0.11
The distribution of cells expressing mu-receptor mRNA and mu-receptor binding sites were compared in brain and spinal cord tissue sections using a combination of in situ hybridization and receptor autoradiographic techniques. mu-Receptor mRNA was visualized with a 35S-labeled cRNA probe directed to transmembrane III-VI of the rat mu-receptor, while mu-receptor binding sites were labeled with the mu-selective ligand [3H]DAMGO.
Gene_expression (expressing) of mu-receptor in brain associated with spinal cord
5) Confidence 0.78 Published 1994 Journal Brain Res. Section Abstract Doc Link 8032920 Disease Relevance 0 Pain Relevance 0.11
mu-Opioid receptor mRNA expression in the rat CNS: comparison to mu-receptor binding.
Gene_expression (expression) of mu-Opioid receptor mRNA associated with enkephalin and opioid receptor
6) Confidence 0.78 Published 1994 Journal Brain Res. Section Title Doc Link 8032920 Disease Relevance 0 Pain Relevance 0.38
These studies show for the first time that rat peritoneal macrophages express a mu-opioid receptor.
Gene_expression (express) of mu-opioid receptor in peritoneal macrophages associated with opioid receptor
7) Confidence 0.78 Published 1995 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 7733926 Disease Relevance 0 Pain Relevance 0.42
Increased mu opioid receptor expression in the central amygdaloid nuclei suggests a decreased opioidergic tone at this level that could be involved in fluoxetine anorectic action.
Gene_expression (expression) of mu opioid receptor associated with appetite loss, mu opioid receptor and fluoxetine
8) Confidence 0.78 Published 2006 Journal Int. J. Neurosci. Section Abstract Doc Link 16484055 Disease Relevance 0.34 Pain Relevance 0.61
The aim of this article was to describe the effects of chronic fluoxetine on mu opioid receptor expression in obese Zucker rat extrahypothalamic regions.
Gene_expression (expression) of mu opioid receptor associated with obesity, mu opioid receptor and fluoxetine
9) Confidence 0.78 Published 2006 Journal Int. J. Neurosci. Section Abstract Doc Link 16484055 Disease Relevance 0.27 Pain Relevance 0.56
OBJECTIVES: The aim of this study was to evaluate the antinociceptive and antidepressant-like effects and the possible variations in mu-opioid receptor expression induced by a chronic nefazodone treatment in brain areas related to pain and affective state.
Gene_expression (expression) of mu-opioid receptor in brain
10) Confidence 0.78 Published 2004 Journal Psychopharmacology (Berl.) Section Body Doc Link 15138764 Disease Relevance 0.09 Pain Relevance 0
CONCLUSION: Therefore, chronic nefazodone induces antinociceptive and antidepressant-like effects in rats and increases mu-opioid receptor expression in brain areas related to pain and affective state.
Gene_expression (expression) of mu-opioid receptor in brain
11) Confidence 0.78 Published 2004 Journal Psychopharmacology (Berl.) Section Body Doc Link 15138764 Disease Relevance 0 Pain Relevance 0
Chronic antidepressants could act by increasing mu-opioid receptor expression in many brain areas involved in the regulation of nociception and affective state.
Gene_expression (expression) of mu-opioid receptor in brain associated with nociception and opioid receptor
12) Confidence 0.78 Published 2004 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 15138764 Disease Relevance 0.53 Pain Relevance 0.74
These data show that some splice variants of mu-opioid receptor are widely expressed in rat CNS but question the existence of others that have been reported in the literature.
Gene_expression (expressed) of mu-opioid receptor associated with opioid receptor
13) Confidence 0.78 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18005002 Disease Relevance 0 Pain Relevance 0.49
We did not find convincing evidence that significant levels of MOR1C, MOR1C1, MOR1C2 and MOR1D are present in rat CNS.
Gene_expression (levels) of MOR1C1
14) Confidence 0.78 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18005002 Disease Relevance 0 Pain Relevance 0.34
Striosomal mu receptor expression increased only slightly between postnatal day 5 and adult.
Gene_expression (expression) of Striosomal mu receptor
15) Confidence 0.77 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15860573 Disease Relevance 0 Pain Relevance 0.26
These data also suggest that this increase in G protein coupling is developmentally regulated and that in the developing rat brain the density of mu opioid receptor expression may not necessarily correlate with receptor activation of G proteins.
Gene_expression (expression) of mu opioid receptor in brain associated with mu opioid receptor
16) Confidence 0.77 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15860573 Disease Relevance 0 Pain Relevance 0.23
In the acute treatment, expression levels for the encoded mu-opioid receptor Oprm1, as detected by reverse transcription-polymerase chain reaction, were significantly decreased in the periaqueductal gray.
Gene_expression (expression) of Oprm1 associated with opioid receptor and central grey
17) Confidence 0.77 Published 2006 Journal Neuroscience Section Abstract Doc Link 16753266 Disease Relevance 0.25 Pain Relevance 0.62
In chronic treatment, both Oprk1 and Oprm1 expression levels, that encoded kappa and mu-opioid receptor respectively, showed significant decreases in the periaqueductal gray and striatum.
Gene_expression (expression) of Oprm1 in striatum associated with opioid receptor and central grey
18) Confidence 0.77 Published 2006 Journal Neuroscience Section Abstract Doc Link 16753266 Disease Relevance 0.27 Pain Relevance 0.62
In vitro, thienorphine was more potent than buprenorphine in inhibiting [3H]diprenorphine and stimulating guanosine 5'-O-(3-[35S]thio)triphosphate binding to rat mu-opioid receptor stably expressed in CHO cells.
Gene_expression (expressed) of mu-opioid receptor associated with opioid receptor and buprenorphine
19) Confidence 0.77 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16569757 Disease Relevance 0.07 Pain Relevance 1.30
MOR1 was often detected at these dendro-dendritic appositions that may be gap junctions.
Gene_expression (detected) of MOR1
20) Confidence 0.77 Published 2002 Journal Neuroscience Section Abstract Doc Link 12435423 Disease Relevance 0 Pain Relevance 0.25

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