INT6294

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Context Info
Confidence 0.62
First Reported 1992
Last Reported 2010
Negated 1
Speculated 8
Reported most in Abstract
Documents 28
Total Number 36
Disease Relevance 6.77
Pain Relevance 22.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
spinal 8
brain 7
hypothalamus 6
hippocampus 5
forebrain 4
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 92 100.00 Very High Very High Very High
Opioid 63 100.00 Very High Very High Very High
mu opioid receptor 36 100.00 Very High Very High Very High
cocaine 23 100.00 Very High Very High Very High
Morphine 23 100.00 Very High Very High Very High
methadone 19 100.00 Very High Very High Very High
Opioid receptor 1 19 100.00 Very High Very High Very High
dexamethasone 16 100.00 Very High Very High Very High
fluoxetine 12 100.00 Very High Very High Very High
Peripheral nerve injury 7 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 15 100.00 Very High Very High Very High
Stress 9 100.00 Very High Very High Very High
Arthritis 8 99.88 Very High Very High Very High
Obesity 6 99.84 Very High Very High Very High
Hyperalgesia 30 99.80 Very High Very High Very High
Experimental Arthritis 26 99.40 Very High Very High Very High
Urological Neuroanatomy 6 99.04 Very High Very High Very High
Aids-related Complex 6 98.80 Very High Very High Very High
Pain 20 98.60 Very High Very High Very High
INFLAMMATION 14 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of long-term dexamethasone on both spinal mu-opioid receptor expression and hyperalgesia during persistent AA inflammation are time dependent.
Regulation (effects) of Gene_expression (expression) of mu-opioid receptor in spinal associated with hyperalgesia, inflammation, opioid receptor, dexamethasone and arthritis
1) Confidence 0.62 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671722 Disease Relevance 1.84 Pain Relevance 1.95
The aim of this article was to describe the effects of chronic fluoxetine on mu opioid receptor expression in obese Zucker rat extrahypothalamic regions.
Regulation (effects) of Gene_expression (expression) of mu opioid receptor associated with obesity, mu opioid receptor and fluoxetine
2) Confidence 0.62 Published 2006 Journal Int. J. Neurosci. Section Abstract Doc Link 16484055 Disease Relevance 0.27 Pain Relevance 0.56
These data suggest that mu-opioid receptor expression in the rat forebrain is altered by in vivo chronic fluoxetine treatment.
Regulation (altered) of Gene_expression (expression) of mu-opioid receptor in forebrain associated with opioid receptor and fluoxetine
3) Confidence 0.45 Published 1999 Journal Brain Res. Section Abstract Doc Link 9889376 Disease Relevance 0 Pain Relevance 0.54
These data suggest that mu-opioid receptor expression in the rat forebrain is altered by in vivo chronic lithium treatment.
Regulation (altered) of Gene_expression (expression) of mu-opioid receptor in forebrain associated with opioid receptor
4) Confidence 0.45 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10670775 Disease Relevance 0 Pain Relevance 0.44
By using the 3H-DAMGO binding assay, it was shown that chronic methadone treatment (gestation days 7-20) did not affect mu-receptor capacity in both fetal and maternal brains during gestation day 20, nor when tested 7 days after delivery.
Neg (nor) Regulation (affect) of Gene_expression (capacity) of mu-receptor in brains associated with methadone
5) Confidence 0.45 Published 1992 Journal Neurotoxicol Teratol Section Abstract Doc Link 1326078 Disease Relevance 0 Pain Relevance 0.56
Effects of single and repeated prolonged stress on mu-opioid receptor mRNA expression in rat gross hypothalamic and midbrain homogenates.
Regulation (Effects) of Gene_expression (expression) of mu-opioid receptor mRNA in midbrain associated with stress, midbrain and opioid receptor
6) Confidence 0.44 Published 2003 Journal Brain Res. Section Title Doc Link 12867258 Disease Relevance 0.53 Pain Relevance 0.53
Mu-opioid receptor expression in High Five insect cells is regulated by 5' untranslated region (5'UTR).
Regulation (regulated) of Gene_expression (expression) of Mu-opioid receptor associated with opioid receptor
7) Confidence 0.44 Published 1999 Journal Life Sci. Section Title Doc Link 10201640 Disease Relevance 0.07 Pain Relevance 0.23
Effects of high-dose methadone maintenance on cocaine place conditioning, cocaine self-administration, and mu-opioid receptor mRNA expression in the rat brain.
Regulation (Effects) of Gene_expression (expression) of mu-opioid receptor in brain associated with opioid receptor, methadone and cocaine
8) Confidence 0.40 Published 2006 Journal Neuropsychopharmacology Section Title Doc Link 16237390 Disease Relevance 0.15 Pain Relevance 1.31
Spinal mu-opioid receptor expression was detected by semiquantitative reverse transcription-polymerase chain reaction on Days 6 and 21 following AA induction.
Regulation (detected) of Gene_expression (expression) of mu-opioid receptor in Spinal associated with opioid receptor and arthritis
9) Confidence 0.39 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671722 Disease Relevance 0.92 Pain Relevance 1.09
However, our previous studies found that chronic PL017 (a selective mu-opioid agonist) treatment of adult animals resulted in down regulation of mu opioid receptor levels only after 5 days of PL017 treatment although tolerance had significantly developed after 3 days of PL017 treatment.
Regulation (regulation) of Gene_expression (levels) of mu opioid receptor associated with mu agonist, tolerance and mu opioid receptor
10) Confidence 0.39 Published 1995 Journal Chin J Physiol Section Abstract Doc Link 8846729 Disease Relevance 0 Pain Relevance 0.65
Impact of 6-hydroxydopamine lesions and cocaine exposure on mu-opioid receptor expression and regulation of cholinergic transmission in the limbic-prefrontal territory of the rat dorsal striatum.
Regulation (Impact) of Gene_expression (expression) of mu-opioid receptor in prefrontal associated with opioid receptor and cocaine
11) Confidence 0.27 Published 2007 Journal Eur. J. Neurosci. Section Title Doc Link 17425581 Disease Relevance 0 Pain Relevance 0.67
Chronic arthritis down-regulates peripheral mu-opioid receptor expression with concomitant loss of endomorphin 1 antinociception.
Regulation (regulates) of Gene_expression (expression) of mu-opioid receptor associated with antinociception, nociceptor, opioid receptor and arthritis
12) Confidence 0.27 Published 2005 Journal Arthritis Rheum. Section Title Doc Link 16200625 Disease Relevance 0.10 Pain Relevance 0.73
Furthermore, the analgesic effect of endomorphin 1 is lost during chronic inflammation due to down-regulation of mu-opioid receptor expression in afferent nerve cell bodies.
Regulation (regulation) of Gene_expression (expression) of mu-opioid receptor in nerve cell
13) Confidence 0.27 Published 2005 Journal Arthritis Rheum. Section Body Doc Link 16200625 Disease Relevance 0 Pain Relevance 0
However, it is also possible that E2 and P differentially regulate responsiveness to opioids by altering mu-opioid receptor gene expression.
Regulation (altering) of Gene_expression (expression) of mu-opioid receptor gene associated with opioid receptor and opioid
14) Confidence 0.25 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9450674 Disease Relevance 0.08 Pain Relevance 0.23
These findings indicate that differential effects of E2 and P on LH-RH release may be mediated by steroid-specific effects on mu-opioid receptor gene expression in neurons of the POA and/or Arc.
Regulation (effects) of Gene_expression (expression) of mu-opioid receptor gene in neurons associated with aids-related complex and opioid receptor
15) Confidence 0.25 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9450674 Disease Relevance 0.26 Pain Relevance 0.30
Lithium alters mu-opioid receptor expression in the rat brain.
Regulation (alters) of Gene_expression (expression) of mu-opioid receptor in brain associated with opioid receptor
16) Confidence 0.24 Published 2000 Journal Neurosci. Lett. Section Title Doc Link 10670775 Disease Relevance 0 Pain Relevance 0.46
Fluoxetine alters mu opioid receptor expression in obese Zucker rat extrahypothalamic regions.
Regulation (alters) of Gene_expression (expression) of mu opioid receptor associated with obesity, mu opioid receptor and fluoxetine
17) Confidence 0.24 Published 2006 Journal Int. J. Neurosci. Section Title Doc Link 16484055 Disease Relevance 0.29 Pain Relevance 0.62
They also indicate, however, that muOR agonists directly affect a small population of dopaminergic neurons expressing muOR on their dendrites in VTA and/or terminals in target regions.
Regulation (affect) of Gene_expression (expressing) of muOR in dopaminergic neurons associated with ventral tegmentum and agonist
18) Confidence 0.24 Published 2001 Journal Synapse Section Abstract Doc Link 11494402 Disease Relevance 0 Pain Relevance 0.48
Peripheral opioid antinociception is dependent on sensory neuron mu opioid receptor (MOR) expression, coupling and efficacy.
Regulation (dependent) of Gene_expression (expression) of mu opioid receptor in sensory neuron associated with antinociception, mu opioid receptor and opioid
19) Confidence 0.23 Published 2007 Journal Brain Section Abstract Doc Link 17142830 Disease Relevance 0.33 Pain Relevance 1.14
Voluntary ethanol consumption altered mu-opioid receptor function in the cingulate cortex, caudate-putamen (CPu), nucleus accumbens core (Acb C) and shell (Acb S), the expression of tyrosine hydroxylase (TH) in the ventral tegmental area and substantia nigra, proenkephalin (PENK) in the piriform cortex, olfactory tubercle, CPu, Acb C and Acb S, ventromedial nucleus (VMN) and paraventricular nucleus (PVN) of the hypothalamus, corticotropin releasing factor (CRF) in PVN, cannabinoid CB(1) receptor (CB1-R) in the CPu, hippocampus and VMN, and serotonin transporter (5-HTT) in the dorsal and median raphe nuclei.
Regulation (altered) of Gene_expression (function) of mu-opioid receptor in hippocampus associated with ventral tegmentum, cannabinoid, substantia nigra, opioid receptor, nucleus accumbens, hippocampus, serotonin and raphe
20) Confidence 0.23 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17063152 Disease Relevance 0 Pain Relevance 0.47

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