INT62942

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2000
Negated 0
Speculated 2
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 8.22
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Sell) plasma membrane (Sell)
Anatomy Link Frequency
leukocytes 6
coronary artery 4
neutrophils 2
Sell (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 36 99.60 Very High Very High Very High
cINOD 10 99.24 Very High Very High Very High
Angina 54 99.00 Very High Very High Very High
Inflammatory response 7 92.44 High High
Kinase C 1 72.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 39 99.60 Very High Very High Very High
Coronary Artery Disease 30 99.16 Very High Very High Very High
Cv General 3 Under Development 54 99.00 Very High Very High Very High
Adhesions 25 95.40 Very High Very High Very High
Myocardial Infarction 24 94.56 High High
Syndrome 6 54.96 Quite High
Disease 6 38.52 Quite Low
Increased Venous Pressure Under Development 6 36.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Down-regulation of L-selectin expression in neutrophils by nonsteroidal anti-inflammatory drugs: role of intracellular ATP concentration.
Negative_regulation (regulation) of Gene_expression (expression) of L-selectin in neutrophils associated with inflammation and cinod
1) Confidence 0.49 Published 2000 Journal Blood Section Title Doc Link 11071659 Disease Relevance 0.38 Pain Relevance 0.76
Stimulation of leukocytes resulted in a rapid downregulation of surface L-selectin expression, measured by flowcytometry, similar to the suppressed expression of L-selectin found on leukocytes from patients with coronary artery disease.
Negative_regulation (suppressed) of Gene_expression (expression) of L-selectin in coronary artery associated with coronary artery disease
2) Confidence 0.11 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.17 Pain Relevance 0.59
Stimulation of leukocytes resulted in a rapid downregulation of surface L-selectin expression, measured by flowcytometry, similar to the suppressed expression of L-selectin found on leukocytes from patients with coronary artery disease.
Negative_regulation (downregulation) of Gene_expression (expression) of L-selectin in coronary artery associated with coronary artery disease
3) Confidence 0.11 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.20 Pain Relevance 0.61
L-selectin expression was observed to be depressed in patients with severe angina compared with that in members of the control group.
Negative_regulation (depressed) of Gene_expression (expression) of L-selectin associated with angina
4) Confidence 0.11 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.63 Pain Relevance 0.78
This inflammatory process results in downregulation of leukocyte expression of L-selectin and thus lower circulating sL-selectin levels.
Negative_regulation (downregulation) of Gene_expression (expression) of L-selectin in leukocyte associated with inflammation
5) Confidence 0.11 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.01 Pain Relevance 0.45
To examine the mechanism of reduction in sL-selectin levels and L-selectin expression on leukocytes, leukocytes from the control group were stimulated in vitro.
Spec (examine) Negative_regulation (reduction) of Gene_expression (expression) of L-selectin in leukocytes
6) Confidence 0.08 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.41 Pain Relevance 0.76
To examine the mechanism of reduction in sL-selectin levels and L-selectin expression on leukocytes, leukocytes from the control group were stimulated in vitro.
Spec (examine) Negative_regulation (reduction) of Gene_expression (expression) of L-selectin in leukocytes
7) Confidence 0.03 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.41 Pain Relevance 0.76

General Comments

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