INT62944

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Context Info
Confidence 0.47
First Reported 1996
Last Reported 2010
Negated 5
Speculated 3
Reported most in Abstract
Documents 33
Total Number 36
Disease Relevance 23.52
Pain Relevance 7.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
endothelial cell 3
knee 3
plasma 2
blood 2
neutrophil 2
Icam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 10 100.00 Very High Very High Very High
anesthesia 9 100.00 Very High Very High Very High
Inflammation 181 99.44 Very High Very High Very High
Angina 36 99.44 Very High Very High Very High
chemokine 9 99.32 Very High Very High Very High
Chronic pancreatitis 6 98.80 Very High Very High Very High
cINOD 14 98.78 Very High Very High Very High
dexamethasone 7 98.20 Very High Very High Very High
Osteoarthritis 15 98.12 Very High Very High Very High
Cluster headache 10 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 143 100.00 Very High Very High Very High
Cancer 22 100.00 Very High Very High Very High
Necrosis 8 100.00 Very High Very High Very High
Acute Coronary Syndrome 10 99.64 Very High Very High Very High
INFLAMMATION 211 99.44 Very High Very High Very High
Angina 7 99.44 Very High Very High Very High
Coronary Artery Disease 13 99.32 Very High Very High Very High
Increased Venous Pressure Under Development 22 99.28 Very High Very High Very High
Hypertension 53 98.80 Very High Very High Very High
Pancreatitis 6 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of different hyaluronic acid products on synovial fluid levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in knee osteoarthritis.
Regulation (Effects) of intercellular adhesion molecule-1 in knee associated with knee osteoarthritis, osteoarthritis and adhesions
1) Confidence 0.47 Published 2004 Journal Ann. Clin. Lab. Sci. Section Title Doc Link 15487709 Disease Relevance 0.83 Pain Relevance 0.28
The aim of this study was to evaluate the effects of different hyaluronic acid (HA) forms on synovial fluid levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) during the treatment of patients with knee osteoarthritis (OA).
Regulation (effects) of intercellular adhesion molecule-1 in knee associated with knee osteoarthritis, osteoarthritis and adhesions
2) Confidence 0.47 Published 2004 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15487709 Disease Relevance 0.62 Pain Relevance 0.13
The aim of this study was to evaluate the effects of different hyaluronic acid (HA) forms on synovial fluid levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) during the treatment of patients with knee osteoarthritis (OA).
Regulation (effects) of ICAM-1 in knee associated with knee osteoarthritis, osteoarthritis and adhesions
3) Confidence 0.47 Published 2004 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15487709 Disease Relevance 0.62 Pain Relevance 0.13
These data suggest that ICAM-1 may be involved in neutrophil invasion and neurological dysfunction after TBI, but also implicate a role for a nonspecific antibody effect in improved functional outcome.
Regulation (role) of ICAM-1 in neutrophil associated with anesthesia
4) Confidence 0.45 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 12482117 Disease Relevance 0.76 Pain Relevance 0.13
For some experiments, a blocking MAb directed at either ICAM-1 (1A29) or P-selectin (RMP-1) or their isotype-matched controls was injected intravenously 10 min before Indo administration.
Regulation (directed) of ICAM-1
5) Confidence 0.45 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486176 Disease Relevance 0.48 Pain Relevance 0.29
Therefore, we evaluated ICAM-1 expression and the effect of anti-ICAM-1 treatment on motor recovery and neutrophil invasion after traumatic brain injury induced via the lateral fluid-percussion method in the rat.
Regulation (effect) of anti-ICAM-1 in neutrophil associated with brain injury
6) Confidence 0.39 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 12482117 Disease Relevance 0.86 Pain Relevance 0.05
Patients with conditions that affect sICAM-1 levels were ineligible.
Regulation (affect) of sICAM-1
7) Confidence 0.39 Published 2001 Journal Ann Emerg Med Section Body Doc Link 11524640 Disease Relevance 0.18 Pain Relevance 0
, and IL-6) as well as 3 cellular adhesion molecule (ICAM-1, VCAM, and E-selectin) mRNA levels following PBBI (Fig. 2).
Regulation (molecule) of ICAM-1 associated with brain injury and adhesions
8) Confidence 0.36 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1933533 Disease Relevance 1.10 Pain Relevance 0.26
In contrast, the chemokine RANTES or the adhesion molecules ICAM-1 and VCAM-1 were not transcriptionally regulated in the kidney in response to hypertension or diabetes (table 2).
Neg (not) Regulation (regulated) of ICAM-1 in kidney associated with chemokine, diabetes mellitus, hypertension and adhesions
9) Confidence 0.34 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.14 Pain Relevance 0.09
The contents of ESR, TNF-alpha, and ICAM-1 showed downtrend after treatment in the both groups (P<0.05, P<0.01), and the observation group decreased more obviously (all P<0.01).
Regulation (contents) of ICAM-1
10) Confidence 0.32 Published 2010 Journal Zhongguo Zhen Jiu Section Body Doc Link 20496733 Disease Relevance 0.07 Pain Relevance 0
At 3 month follow-up, ICAM-1 level was unchanged in ischaemic heart disease patients.
Neg (unchanged) Regulation (unchanged) of ICAM-1 in heart
11) Confidence 0.29 Published 2001 Journal Eur. Heart J. Section Body Doc Link 11440495 Disease Relevance 0.19 Pain Relevance 0
As sICAM-1 was not affected by the acute event this plasma marker may be an important risk factor for the development of the acute coronary syndrome, particularly unstable angina.


Neg (not) Regulation (affected) of sICAM-1 in plasma
12) Confidence 0.25 Published 2001 Journal Eur. Heart J. Section Body Doc Link 11440495 Disease Relevance 0 Pain Relevance 0
Indeed, down-regulation of ICAM-1 on vascular endothelial cells can attenuate hepatic I/Ri both in vitro and in vivo [42,43].
Regulation (regulation) of ICAM-1 in endothelial cells
13) Confidence 0.24 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.31 Pain Relevance 0.11
Overall these data indicate that ICAM-1 is a likely molecular target for the anti-inflammatory action exerted by dexamethasone.
Spec (likely) Regulation (target) of ICAM-1 associated with inflammation and dexamethasone
14) Confidence 0.24 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274931 Disease Relevance 0.39 Pain Relevance 0.54
The up-regulated genes include 7 MMPs (MMP 2, MMP 8, MMP 9, MMP 10, MMP 11, MMP 12, MMP 20), 1 serine protease (Plat), 3 cell adhesion molecules (ICAM-1, NCAM-1, Itgax), and 1 protease inhibitor (Serpinb2).
Regulation (regulated) of ICAM-1 associated with metalloproteinase and adhesions
15) Confidence 0.18 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.28 Pain Relevance 0.05
In group 1A, the ICAM-1 decreased significantly at second blood samplings (310 +/- 28 vs 368 +/- 30 ng/ml; p <0.001), whereas in group 1B there was no significant change in ICAM-1 (357 +/- 33 vs 359 +/- 26 ng/ml; p = NS).
Neg (no) Regulation (change) of ICAM-1 in blood
16) Confidence 0.18 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9416930 Disease Relevance 0.22 Pain Relevance 0.23
Additionally, when endothelial dysfunction was defined as FMD < or = 5.5%, patients with FMD below this value had higher plasma concentrations of sICAM-1 and sVCAM-1 than those with FMD > 5.5%.
Regulation (concentrations) of sICAM-1 in plasma associated with increased venous pressure under development
17) Confidence 0.17 Published 2001 Journal Thromb. Haemost. Section Abstract Doc Link 11204590 Disease Relevance 1.26 Pain Relevance 0.08
The aim of this study was to investigate the prognostic value of plasma sICAM-1 levels in patients with acute chest pain compatible with myocardial ischemia.
Spec (investigate) Regulation (value) of sICAM-1 in chest associated with angina, coronary artery disease and ischemia
18) Confidence 0.17 Published 2001 Journal Ann Emerg Med Section Abstract Doc Link 11524640 Disease Relevance 0.78 Pain Relevance 0.35
In conclusion, altered cICAM-1 and sL-selectin levels in patients with coronary artery disease reflect the presence of a chronic inflammatory process.
Regulation (altered) of cICAM-1 in coronary artery associated with coronary artery disease and inflammation
19) Confidence 0.17 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.13 Pain Relevance 0.47
To characterize the role of circulating intercellular adhesion molecules (ICAM-1) and E-selectin in patients with acute coronary syndrome, serum levels of ICAM-1 and E-selectin were measured by enzyme-linked immunosorbent assay (ELISA).
Regulation (measured) of ICAM-1 associated with acute coronary syndrome and adhesions
20) Confidence 0.16 Published 1996 Journal Chest Section Abstract Doc Link 8769521 Disease Relevance 0.75 Pain Relevance 0.17

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