INT62945

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 12
Total Number 19
Disease Relevance 12.86
Pain Relevance 3.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (SELL) plasma membrane (SELL)
Anatomy Link Frequency
monocytes 9
neutrophil 9
leukocytes 6
granulocytes 4
upper limb 2
SELL (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 7 99.34 Very High Very High Very High
Inflammatory response 78 97.84 Very High Very High Very High
Angina 23 96.76 Very High Very High Very High
aspirin 6 93.84 High High
Percutaneous transluminal coronary angioplasty 3 93.84 High High
Paracetamol 3 91.64 High High
Inflammation 220 87.28 High High
Pain 4 81.92 Quite High
cytokine 136 73.76 Quite High
cva 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibromyalgia 6 99.34 Very High Very High Very High
Adhesions 275 98.94 Very High Very High Very High
Disease 34 98.88 Very High Very High Very High
Brain Injury 216 98.08 Very High Very High Very High
INFLAMMATION 341 97.48 Very High Very High Very High
Cv General 3 Under Development 28 96.76 Very High Very High Very High
Death 19 96.76 Very High Very High Very High
Stable Angina Pectoris 3 95.80 Very High Very High Very High
Shock 21 93.76 High High
Muscular Dystrophy 70 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As compared to age and sex-matched healthy controls, FM patients showed a significantly decreased expression of CD62L (p < 0.01) and CD11b/CD18 (p < 0.05) on polymorphonuclear leukocytes.
Negative_regulation (decreased) of Gene_expression (expression) of CD62L in polymorphonuclear leukocytes associated with fibrositis
1) Confidence 0.58 Published 2009 Journal Rheumatol. Int. Section Abstract Doc Link 19052753 Disease Relevance 0.78 Pain Relevance 0.39
Thus increased expression of CD11b and decreased expression of CD62L by neutrophils and monocytes may play a central role as the mechanism by which leukocyte adhesion and consequently activation occurs following surgery [2], [21], [26].
Negative_regulation (decreased) of Gene_expression (expression) of CD62L in monocytes associated with adhesions
2) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.80 Pain Relevance 0.08
During this investigation there was evidence of decreased CD62L expression at the cell surface of neutrophils probably due to shedding of this adhesion molecule.
Negative_regulation (decreased) of Gene_expression (expression) of CD62L in neutrophils associated with adhesions
3) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.86 Pain Relevance 0.11
Furthermore, the current results showing reduced surface expression of CD62L in HSD-treated patients, accompanied by corresponding increases in sL-selectin and better patient outcome, are in accordance with our previous findings in shock patients [14], and supports the theory that sL-selectin shedding represents an endogenous regulatory mechanism to limit leukocyte-mediated injury [79].


Negative_regulation (reduced) of Gene_expression (expression) of CD62L in leukocyte associated with injury and shock
4) Confidence 0.51 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.97 Pain Relevance 0.14
RESULTS: Aceclofenac induced a dramatic decrease of L-selectin expression, whereas a moderate and slight decrement of CD43 and ICAM-3 expression was also observed.
Negative_regulation (decrease) of Gene_expression (expression) of L-selectin
5) Confidence 0.41 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8730134 Disease Relevance 0.13 Pain Relevance 0
Following tourniquet-applied upper limb orthopaedic surgery, there was a decrease in neutrophil CD62L expression (p?
Negative_regulation (decrease) of Gene_expression (expression) of CD62L in neutrophil
6) Confidence 0.38 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2911384 Disease Relevance 0.30 Pain Relevance 0.10
Following tourniquet-applied upper limb orthopaedic surgery CD62L expression decreased on neutrophils (p?
Negative_regulation (decreased) of Gene_expression (expression) of CD62L in upper limb
7) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0 Pain Relevance 0
Expression of CD62L by PMNs and monocytes were elevated in the NS group across all sample times relative to control, whereas HSD treatment significantly down-regulated CD62L expression at all time points.
Negative_regulation (regulated) of Gene_expression (expression) of CD62L in monocytes
8) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.21 Pain Relevance 0
Expression of CD62L by PMNs and monocytes were elevated in the NS group across all sample times relative to control, whereas HSD treatment significantly down-regulated CD62L expression at all time points.
Negative_regulation (down) of Gene_expression (expression) of CD62L in monocytes
9) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.21 Pain Relevance 0
L-selectin expression decreased, particularly on monocytes.
Negative_regulation (decreased) of Gene_expression (expression) of L-selectin in monocytes
10) Confidence 0.35 Published 1999 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 10051263 Disease Relevance 1.01 Pain Relevance 0.31
METHODS: We used flow cytometry analysis to determine peripheral blood neutrophil expression of L-selectin, CD11a, CD11b, CD31, CD43, CD44, and intercellular adhesion molecule 2 (ICAM-3) surface adhesion molecules after treatment with aceclofenac, diclofenac, or dexamethasone.
Spec (determine) Negative_regulation (determine) of Spec (determine) Gene_expression (expression) of L-selectin in neutrophil
11) Confidence 0.30 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8730134 Disease Relevance 0.19 Pain Relevance 0
Several studies have demonstrated an increased expression of CD18 and

CD11b adhesion molecules on granulocytes after 15-30 min of haemodialysis, whereas the expression of CD62L on granulocytes was decreased.

Negative_regulation (decreased) of Gene_expression (expression) of CD62L in granulocytes associated with adhesions
12) Confidence 0.28 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 1.23 Pain Relevance 0
We did not observe any significant changes in the

adhesion molecules on granulocytes, but only a tendency to a decrease in CD62L levels 2 h after the start of CVVHD.

Negative_regulation (decrease) of Gene_expression (levels) of CD62L in granulocytes associated with adhesions
13) Confidence 0.20 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 0.82 Pain Relevance 0
Thus increased expression of CD11b and decreased expression of CD62L by neutrophils and monocytes may play a central role as the mechanism by which leukocyte adhesion and consequently activation occurs following surgery [2], [21], [26].
Negative_regulation (decreased) of in neutrophils Gene_expression (expression) of CD62L in monocytes associated with adhesions
14) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.80 Pain Relevance 0.08
The elevated expression of antigen-presenting and co-stimulatory molecules, but reduced levels of CD62L, indicate a highly activated state for these eosinophils.
Negative_regulation (reduced) of Gene_expression (levels) of CD62L in eosinophils
15) Confidence 0.16 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.39 Pain Relevance 0
Moreover, the levels of CD133+CXCR4+CD34- cells expressing L-selectin and VCAM-1 decrease with age and course of the disease.
Negative_regulation (decrease) of Gene_expression (expressing) of L-selectin associated with disease
16) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.67 Pain Relevance 0.06
To examine the mechanism of reduction in sL-selectin levels and L-selectin expression on leukocytes, leukocytes from the control group were stimulated in vitro.
Spec (examine) Negative_regulation (reduction) of Gene_expression (expression) of sL-selectin in leukocytes
17) Confidence 0.03 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.41 Pain Relevance 0.76
After recanalization, the levels of sE-selectin and sL-selectin were significantly decreased (sE-selectin 54 +/- 15 to 42 +/- 11 ng/ml, sL-selectin 1104 +/- 106 to 891 +/- 59 ng/ml, P < 0.05, respectively).
Negative_regulation (decreased) of Gene_expression (levels) of sL-selectin
18) Confidence 0.03 Published 1997 Journal Vasc Med Section Abstract Doc Link 9546964 Disease Relevance 0.67 Pain Relevance 0.44
To examine the mechanism of reduction in sL-selectin levels and L-selectin expression on leukocytes, leukocytes from the control group were stimulated in vitro.
Spec (examine) Negative_regulation (reduction) of Gene_expression (expression) of sL-selectin in leukocytes
19) Confidence 0.01 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.41 Pain Relevance 0.76

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