INT62950

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 73
Total Number 75
Disease Relevance 65.91
Pain Relevance 6.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (NPPB) extracellular region (NPPB) nucleus (NPPB)
cytoplasm (NPPB)
Anatomy Link Frequency
heart 10
plasma 7
brain 4
myocardium 3
ventricles 2
NPPB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 375 100.00 Very High Very High Very High
Inflammatory response 64 100.00 Very High Very High Very High
Catecholamine 55 100.00 Very High Very High Very High
ischemia 331 99.96 Very High Very High Very High
cva 224 99.32 Very High Very High Very High
cytokine 134 99.20 Very High Very High Very High
Enkephalin 4 98.62 Very High Very High Very High
imagery 64 98.08 Very High Very High Very High
Angina 513 97.68 Very High Very High Very High
chemokine 1 89.84 High High
Disease Link Frequency Relevance Heat
Natriuresis 514 100.00 Very High Very High Very High
INFLAMMATION 423 100.00 Very High Very High Very High
Cv Unclassified Under Development 288 99.96 Very High Very High Very High
Stress 171 99.96 Very High Very High Very High
Urological Neuroanatomy 384 99.90 Very High Very High Very High
Injury 835 99.88 Very High Very High Very High
Thyroid Disease 23 99.86 Very High Very High Very High
Acute Coronary Syndrome 968 99.84 Very High Very High Very High
Multiple Organ Failure 714 99.80 Very High Very High Very High
Necrosis 318 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The failing heart produces a variety of biologically active humoral factors such as catecholamines, vasopressin, angiotensin II, aldosterone, atrial natriuretic polypeptide (ANP), brain natriuretic polypeptide (BNP), cytokines and so on, in order to recover the cardiac function through the mechano- and chemo-receptors in vivo.
Gene_expression (produces) of natriuretic in brain associated with natriuresis, catecholamine and cytokine
1) Confidence 0.75 Published 2007 Journal Rinsho Byori Section Abstract Doc Link 18283862 Disease Relevance 0.62 Pain Relevance 0.21
The failing heart produces a variety of biologically active humoral factors such as catecholamines, vasopressin, angiotensin II, aldosterone, atrial natriuretic polypeptide (ANP), brain natriuretic polypeptide (BNP), cytokines and so on, in order to recover the cardiac function through the mechano- and chemo-receptors in vivo.
Gene_expression (produces) of natriuretic in brain associated with natriuresis, catecholamine and cytokine
2) Confidence 0.75 Published 2007 Journal Rinsho Byori Section Abstract Doc Link 18283862 Disease Relevance 0.63 Pain Relevance 0.21
The overexpression of ANP and BNP suggests an anti-angiogenic effect in ischemic heart disease.
Gene_expression (overexpression) of BNP in heart associated with coronary artery disease
3) Confidence 0.75 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15313204 Disease Relevance 0.57 Pain Relevance 0.19
Both ANP and BNP but not vascular endothelial growth factor (VEGF) and VEGF-receptor 1 and 2 were overexpressed in ischemic regions compared to non-ischemic regions as measured by real-time PCR.
Gene_expression (overexpressed) of BNP
4) Confidence 0.75 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15313204 Disease Relevance 0.63 Pain Relevance 0.22
ANP and BNP but not VEGF are regionally overexpressed in ischemic human myocardium.
Gene_expression (overexpressed) of BNP in myocardium
5) Confidence 0.75 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 15313204 Disease Relevance 0.59 Pain Relevance 0.22
Post-traumatic alterations of NT-proBNP
Gene_expression (alterations) of NT-proBNP
6) Confidence 0.67 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 0.71 Pain Relevance 0.05
Gene expression profiling of human hibernating myocardium: increased expression of B-type natriuretic peptide and proenkephalin in hypocontractile vs normally-contracting regions of the heart.
Gene_expression (expression) of B-type natriuretic peptide in heart associated with natriuresis and enkephalin
7) Confidence 0.66 Published 2008 Journal Eur. J. Heart Fail. Section Title Doc Link 18974021 Disease Relevance 0.31 Pain Relevance 0.28
The expression of B-type natriuretic peptide (BNP) was increased in hypocontractile relative to normally-contracting myocardium.
Gene_expression (expression) of B-type natriuretic peptide in myocardium associated with natriuresis
8) Confidence 0.66 Published 2008 Journal Eur. J. Heart Fail. Section Abstract Doc Link 18974021 Disease Relevance 0.34 Pain Relevance 0.08
Changes in plasma BNP and ANP levels did not differ between the groups (P=0.212 and 0.356).
Gene_expression (levels) of BNP in BNP
9) Confidence 0.65 Published 2009 Journal Acta Anaesthesiol Scand Section Body Doc Link 19419350 Disease Relevance 0 Pain Relevance 0
Univariate regression analyses showed that NT-proBNP levels were correlated with a pathological outcome at MPI (r2?
Gene_expression (levels) of BNP associated with imagery
10) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995735 Disease Relevance 0.55 Pain Relevance 0.12
Thus, its clinical usefulness for the differential diagnosis of heart failure is important.18)19) Elevated body mass index (BMI) and obesity have been associated with hypertension, insulin resistance and recent studies demonstrated that obesity is associated with decreased levels of NT-proBNP and raised concerns about the diagnostic and prognostic validity of natriuretic peptides in obese patients.11)20) Several potential mechanistic explanations deserve consideration.
Gene_expression (levels) of NT-proBNP in body associated with natriuresis, hypertension, obesity, insulin resistance and myocardial infarction
11) Confidence 0.60 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801462 Disease Relevance 1.72 Pain Relevance 0.03
Analysis of NT-proBNP in serum
Gene_expression (Analysis) of NT-proBNP
12) Confidence 0.58 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 1.12 Pain Relevance 0.03
For calculating the correlations between NT-proBNP values and MODS score as well as between NT-proBNP values and CI, bivariate analyses with Spearman correlation were calculated.
Gene_expression (values) of NT-proBNP associated with multiple organ failure
13) Confidence 0.58 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 0.45 Pain Relevance 0
Regarding the issue of BNP alteration in trauma patients, Kia and colleagues [15] reported BNP levels below normal as an indicator for intravascular volume loss and therefore as an initial marker of bleeding.
Gene_expression (levels) of BNP associated with injury and hemorrhage
14) Confidence 0.58 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 0.71 Pain Relevance 0.03
Synthetic human NT-proBNP was used for standardization.


Gene_expression (Synthetic) of NT-proBNP
15) Confidence 0.58 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 0.88 Pain Relevance 0
For calculating the correlations between NT-proBNP values and MODS score as well as between NT-proBNP values and CI, bivariate analyses with Spearman correlation were calculated.
Gene_expression (values) of NT-proBNP associated with multiple organ failure
16) Confidence 0.58 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 0.35 Pain Relevance 0
Systemic inflammatory response and NT-proBNP
Gene_expression (response) of NT-proBNP associated with inflammatory response
17) Confidence 0.58 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 1.10 Pain Relevance 0.11
Among various laboratory data, the peak levels of creatine kinase MB (CK-MB), TnI, and N-terminal pro b-type natriuretic peptide (NT-pro-BNP) were evaluated for estimation of the infarction burden.
Gene_expression (levels) of BNP associated with natriuresis and infarction
18) Confidence 0.58 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771835 Disease Relevance 1.03 Pain Relevance 0.07
Plasma NT-proBNP values did not correlate with LV filling pressure represented by mitral E/Ea in obese diabetic patients (r=0.14, p=0.56).
Gene_expression (values) of NT-proBNP in Plasma associated with diabetes mellitus and obesity
19) Confidence 0.58 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801462 Disease Relevance 1.59 Pain Relevance 0
Moreover, DM patients may be more likely to excrete NT-proBNP (and BNP) in response to a similar degree of ischemic insult,27) and then the higher NT-proBNP concentrations that we observed in patients with DM in the absence of overt HF, a finding considered to represent a "summation effect" of risk factors for structural heart disease, may still indicate an increased risk for cardiovascular morbidity and mortality.
Gene_expression (concentrations) of NT-proBNP in heart associated with heart disease and diabetes mellitus
20) Confidence 0.58 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801462 Disease Relevance 1.32 Pain Relevance 0.17

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