INT62958

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 8.61
Pain Relevance 4.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCR2) plasma membrane (CXCR2) intracellular (CXCR2)
signal transducer activity (CXCR2)
Anatomy Link Frequency
nasopharynx 1
fibroblasts 1
glandular epithelial cell 1
T-cells 1
CXCR2 (Homo sapiens)
CXCR2 - I148E (1)
Pain Link Frequency Relevance Heat
chemokine 305 100.00 Very High Very High Very High
agonist 83 99.98 Very High Very High Very High
Potency 14 99.96 Very High Very High Very High
rheumatoid arthritis 213 99.36 Very High Very High Very High
endometriosis 70 97.36 Very High Very High Very High
cytokine 56 95.48 Very High Very High Very High
Inflammation 83 95.08 Very High Very High Very High
pulpitis 2 93.44 High High
antagonist 55 92.00 High High
headache 1 89.84 High High
Disease Link Frequency Relevance Heat
Breast Cancer 90 99.52 Very High Very High Very High
Rheumatoid Arthritis 213 99.36 Very High Very High Very High
Aging 28 99.16 Very High Very High Very High
Choristoma 8 97.72 Very High Very High Very High
Endometriosis 81 97.36 Very High Very High Very High
Disease 41 96.64 Very High Very High Very High
INFLAMMATION 99 95.08 Very High Very High Very High
Granuloma 2 93.80 High High
Pulpitis 2 93.44 High High
Cancer 116 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The upregulation of CXCR2 could not be calculated for mathematical reasons because the signal intensity of CXCR2 in non-RA tissue after correction for the background was zero.
Positive_regulation (upregulation) of CXCR2 associated with rheumatoid arthritis
1) Confidence 0.59 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.21 Pain Relevance 0.78
Given the importance of IL-8 and CXCR2 in angiogenesis, we investigated the relationship between polymorphisms -251 T/A in IL-8 gene and (+1208) C/T in CXCR2 gene and breast carcinoma.
Positive_regulation (importance) of CXCR2 associated with breast cancer
2) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.22 Pain Relevance 0
The rank order of agonist potency, based on inspection of the mean effective concentration values (EC50), for IL8RB was GROgamma (1 nM) > IL-8 (4 nM) approximately GROalpha (5 nM) approximately GRObeta (4 nM) approximately NAP-2 (7 nM) > ENA-78 (11 nM), and for IL8RA was IL-8 (4 nM) >>> ENA-78 (40 nM) approximately NAP-2 (45 nM) > GROalpha (63 nM) approximately GROgamma (65 nM) >> GRObeta.
Positive_regulation (based) of IL8RB associated with agonist and potency
3) Confidence 0.42 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8702798 Disease Relevance 0 Pain Relevance 0.33
The maximal response of IL8RA to IL-8 was at least 2-fold greater than the other five chemokines.
Positive_regulation (response) of IL8RA associated with chemokine
4) Confidence 0.42 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8702798 Disease Relevance 0 Pain Relevance 0.44
Serum levels of soluble IL-2 receptor and lysozyme were increased, and a significant uptake was observed by Ga scintigraphy at the nasopharynx and bilateral hilar lymphnodes.
Positive_regulation (increased) of IL-2 receptor in nasopharynx
5) Confidence 0.42 Published 2001 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 11280897 Disease Relevance 0.89 Pain Relevance 0.09
IL-8 mediates its effects through the activation of two high-affinity G-protein coupled receptors, CXCR1 and CXCR2 [29], both of which are expressed by LNCaP cells [30], [31].
Positive_regulation (activation) of CXCR2
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.75 Pain Relevance 0.03
Furthermore, glandular epithelial cell localisation and upregulation of immunoreactive CXCR1 and CXCR2, which bind CXCL8, has been demonstrated in eutopic and ectopic tissue sections from endometriosis patients when compared to controls [54].
Positive_regulation (upregulation) of CXCR2 in glandular epithelial cell associated with choristoma and endometriosis
7) Confidence 0.24 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 1.05 Pain Relevance 0.61
Indeed, when over-expressed in primary fibroblasts, IL-8 and one of its known receptor, CXCR2 were sufficient to induce premature senescence (acidic ?
Positive_regulation (sufficient) of CXCR2 in fibroblasts associated with aging
8) Confidence 0.21 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.57 Pain Relevance 0.50
i2, we therefore examined the time course of induction of c-Myc–I148E hCXCR2–C352I G?
Spec (examined) Positive_regulation (induction) of hCXCR2
9) Confidence 0.21 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.27
The same was true when, based on sequence comparisons and a central role for hydrophobic residues in the second intracellular loop of class A GPCRs in agonist activation of G-proteins [43], an I148E hCXCR2–C352I G?
Positive_regulation (activation) of hCXCR2 (I148E) associated with agonist
10) Confidence 0.21 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.07 Pain Relevance 0.09
The chemokine receptor genes were differentially expressed, with upregulation of CXCR4, CCRL2 and CCR5 and downregulation of CXCR1 and CXCR2.
Positive_regulation (upregulation) of CXCR2 associated with chemokine
11) Confidence 0.18 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212580 Disease Relevance 0.63 Pain Relevance 0.36
When we co-expressed pairs of such fusion proteins in which, in the first, the CXCR2 receptor was not signal-transduction-competent because of the introduction of a mutation into the second intracellular loop, whereas in the second the DOP receptor was wild-type but the linked G-protein was modified to prevent guanine-nucleotide exchange, DOP agonists were able to cause activation of the wild-type G-protein linked to the CXCR2 receptor in a concentration-dependent manner.
Positive_regulation (activation) of CXCR2 receptor associated with agonist
12) Confidence 0.16 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.34
At low energy acceptor (hCXCR2–GFP2) to energy donor (hCXCR2–Renilla luciferase) ratios the BRET signal increased with increasing [acceptor] to [donor] ratios, but this asymptotically approached a maximal value at higher [acceptor] to [donor] ratios (Figure 2C).
Positive_regulation (increased) of hCXCR2
13) Confidence 0.15 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0
are potent inducers of several other chemokines such as the main CXCR1 and CXCR2 ligand CXCL8.
Positive_regulation (inducers) of CXCR2 associated with chemokine
14) Confidence 0.11 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.89 Pain Relevance 0.66
It has been recently demonstrated that CXC chemokine ligand 10 (CXCL10) chemoattracts CXC chemokine receptor 3 (CXCR3)-positive activated T-cells.
Positive_regulation (activated) of CXC chemokine receptor 3 in T-cells associated with chemokine
15) Confidence 0.10 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 18037659 Disease Relevance 0.33 Pain Relevance 0.43

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