INT62959

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Context Info
Confidence 0.61
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.47
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCR2) plasma membrane (CCR2) cytoplasm (CCR2)
signal transducer activity (CCR2)
CCR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 21 99.32 Very High Very High Very High
Multiple sclerosis 6 99.32 Very High Very High Very High
imagery 1 98.12 Very High Very High Very High
Inflammation 12 94.44 High High
Neuritis 1 89.28 High High
agonist 3 75.00 Quite High
abdominal pain 1 66.72 Quite High
headache 1 66.08 Quite High
antagonist 2 59.08 Quite High
Potency 1 58.96 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 6 99.32 Very High Very High Very High
INFLAMMATION 14 94.44 High High
Hypersensitivity 11 94.32 High High
Optic Neuritis 1 89.28 High High
Multiple Sclerosis 1 79.88 Quite High
Disease 4 77.56 Quite High
Vomiting 1 67.12 Quite High
Contact Dermatitis 28 66.72 Quite High
Abdominal Pain 1 66.72 Quite High
Headache 1 66.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that the inhibitory effects of evodiamine and rutaecarpine on LIGHT-induced migration and the activation of CCR1, CCR2, ICAM-1, ERK, and p38 MAPK occurs via decreased ROS production and NADPH oxidase activation.
Positive_regulation (activation) of CCR2
1) Confidence 0.61 Published 2009 Journal J. Cell. Biochem. Section Abstract Doc Link 19241441 Disease Relevance 0.26 Pain Relevance 0.17
They have a broad array of functional T1- and T2-associated chemokine receptors, but also express high levels of CCR2 and CCR8 which allow resting as well as activated Th IL-10 cells to display a significant migratory capacity to CCL2 and CCL1 [46].


Positive_regulation (levels) of CCR2 associated with chemokine
2) Confidence 0.23 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.36 Pain Relevance 0.18
Our findings suggest a limited role for CCL2/CCR2 in early active MS.
Positive_regulation (role) of CCR2 associated with multiple sclerosis
3) Confidence 0.13 Published 2004 Journal Eur. J. Neurol. Section Abstract Doc Link 15257681 Disease Relevance 0.85 Pain Relevance 0.55
Two human chemotactic receptor subtypes for IL-8, named IL-8 receptors (IL8R) A and B, have been cloned.
Positive_regulation (subtypes) of chemotactic receptor
4) Confidence 0.02 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8702798 Disease Relevance 0 Pain Relevance 0.22

General Comments

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