INT62960

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Context Info
Confidence 0.77
First Reported 1996
Last Reported 2010
Negated 4
Speculated 7
Reported most in Abstract
Documents 149
Total Number 156
Disease Relevance 58.31
Pain Relevance 59.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx2)
Anatomy Link Frequency
neurons 20
DRG 18
oocytes 10
microglial cells 8
spinal cord 7
P2rx2 (Rattus norvegicus)
P2rx2 - K69C (1)
Pain Link Frequency Relevance Heat
antagonist 541 100.00 Very High Very High Very High
qutenza 404 100.00 Very High Very High Very High
Calcitonin gene-related peptide 111 100.00 Very High Very High Very High
nociceptor 100 100.00 Very High Very High Very High
substance P 77 100.00 Very High Very High Very High
Neuropeptide 41 100.00 Very High Very High Very High
vanilloid receptor subtype 1 12 100.00 Very High Very High Very High
Dorsal horn 152 99.96 Very High Very High Very High
allodynia 88 99.90 Very High Very High Very High
dorsal root ganglion 497 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 521 99.98 Very High Very High Very High
Neuropathic Pain 329 99.90 Very High Very High Very High
Apoptosis 130 99.76 Very High Very High Very High
Brain Disease 17 99.74 Very High Very High Very High
Muscle Weakness 8 99.68 Very High Very High Very High
Cancer Pain 8 99.64 Very High Very High Very High
Ganglion Cysts 639 99.60 Very High Very High Very High
Mouth Cancer 8 99.54 Very High Very High Very High
INFLAMMATION 564 99.52 Very High Very High Very High
Nervous System Injury 161 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, inflammation caused a twofold to threefold increase in both ATP-activated currents, altered the voltage dependence of P2X receptors, and enhanced the expression of P2X2 and P2X3 receptors.
Gene_expression (expression) of P2X2 associated with addiction and inflammation
1) Confidence 0.77 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11756492 Disease Relevance 0.88 Pain Relevance 0.68
P2X2 and P2X3 receptors expressed in mammalian sensory neurons participate in nociception.
Gene_expression (expressed) of P2X2 in sensory neurons associated with nociception
2) Confidence 0.76 Published 2006 Journal Pflugers Arch. Section Abstract Doc Link 16741755 Disease Relevance 0.37 Pain Relevance 0.36
Heterogeneity of the functional expression of P2X3 and P2X2/3 receptors in the primary nociceptive neurons of rat.
Gene_expression (expression) of P2X2 in neurons associated with nociception and pain
3) Confidence 0.75 Published 2001 Journal Neurochem. Res. Section Title Doc Link 11699951 Disease Relevance 0.19 Pain Relevance 0.14
These responses resembled those recorded from 1321N1 cells expressing recombinant heteromultimeric rat P2X2/3 receptors.
Gene_expression (expressing) of P2X2 in 1321N1
4) Confidence 0.75 Published 1999 Journal J. Neurophysiol. Section Abstract Doc Link 10482772 Disease Relevance 0.14 Pain Relevance 0.35
The superficial layers of the spinal cord dorsal horn (DH) express P2X2, P2X4, and P2X6 subunits entering into the formation of ionotropic (P2X) receptors for ATP.
Gene_expression (express) of P2X2 in spinal cord dorsal horn associated with dorsal horn and spinal cord
5) Confidence 0.72 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10704486 Disease Relevance 0 Pain Relevance 0.37
P2X receptors have been suggested to be expressed on the central terminals of A delta-afferent fibers innervating dorsal horn lamina V and play a role in modulating sensory synaptic transmission.
Gene_expression (expressed) of P2X in lamina associated with dorsal horn
6) Confidence 0.68 Published 2003 Journal J. Neurophysiol. Section Abstract Doc Link 12783957 Disease Relevance 0 Pain Relevance 0.15
Most of the P2X-IR was co-expressed on these individual nodose neurons (P2X1/P2X3 or P2X2/P2X3).
Gene_expression (co-expressed) of P2X2 in neurons
7) Confidence 0.65 Published 2001 Journal Neuroreport Section Abstract Doc Link 11588618 Disease Relevance 0.09 Pain Relevance 0
Are there functional P2X receptors on cell bodies in intact dorsal root ganglia of rats?
Gene_expression (Are) of P2X in dorsal root ganglia associated with qutenza
8) Confidence 0.64 Published 1998 Journal Neuroscience Section Title Doc Link 9697129 Disease Relevance 0.15 Pain Relevance 0.60
P2X3 receptors are expressed on about a third of DRG neurons, nearly all of them small diameter [2], but there are also other populations of DRG neurons that express P2X2/3, P2X2 and P2X1 receptors [25] as well as P2Y metabotropic receptors [4, 26].
Gene_expression (express) of P2X2 in neurons
9) Confidence 0.63 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2104004 Disease Relevance 0 Pain Relevance 0.34
P2X3 receptors are expressed on about a third of DRG neurons, nearly all of them small diameter [2], but there are also other populations of DRG neurons that express P2X2/3, P2X2 and P2X1 receptors [25] as well as P2Y metabotropic receptors [4, 26].
Gene_expression (express) of P2X2 in neurons
10) Confidence 0.63 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2104004 Disease Relevance 0 Pain Relevance 0.34
This pharmacological profile is consistent with expression of P2X2 and/or P2X5 purinergic receptor channels.
Gene_expression (expression) of P2X2
11) Confidence 0.62 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8702891 Disease Relevance 0 Pain Relevance 0.19
We cannot rule out the NO released from the blood vessels given the fact that P2X receptors is expressed in endothelial cells [40, 41], although it is not clear the ex-tracellular ATP levels and the contribution of the endothelial P2X receptors to the NO elevation under hypoxic conditions.
Gene_expression (expressed) of P2X in blood vessels associated with hypoxia
12) Confidence 0.61 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.55 Pain Relevance 0
These results suggest that TNP-ATP-resistant P2X receptor subtypes are expressed on capsaicin-insensitive A delta-afferent fibers and play a role in modulating sensory transmission to lamina V neurons.
Gene_expression (expressed) of P2X in lamina associated with qutenza
13) Confidence 0.59 Published 2003 Journal J. Neurophysiol. Section Abstract Doc Link 12783957 Disease Relevance 0.07 Pain Relevance 0.32
Fig. 2Effect of PMA on ATP-induced currents mediated by expressed P2X2 and P2X3 receptors in X. laevis oocytes. a The electrical membrane capacitance was monitored as a measure of the oocyte surface area during sustained stimulation with PMA.
Gene_expression (expressed) of P2X2 in oocyte
14) Confidence 0.57 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.05
Fig. 3Immunoblots show no constitutive phosphorylation of oocyte-expressed P2X2 or P2X3 receptors.
Gene_expression (expressed) of P2X2 in oocyte
15) Confidence 0.57 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0
Boue-Grabot et al. [19] have demonstrated phosphorylation of P2X2 receptors expressed in HEK293 cells.
Gene_expression (expressed) of P2X2
16) Confidence 0.57 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.04
Expressions of P2X2 and P2X3 receptors in rat nodose neurons after myocardial ischemia injury.
Gene_expression (Expressions) of P2X2 in neurons associated with coronary artery disease, ischemia, injury and neuropeptide
17) Confidence 0.54 Published 2009 Journal Auton Neurosci Section Title Doc Link 19064335 Disease Relevance 0.62 Pain Relevance 0.42
Trigeminal primary afferents expressing P2X(3) receptor are involved in the transmission of orofacial nociceptive information.
Gene_expression (expressing) of P2X associated with nociception
18) Confidence 0.53 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18067147 Disease Relevance 0.22 Pain Relevance 0.10
Purinergic transmission is indicative because of the expression of purinoceptor subunits P2X2 and P2X3 in the nerve fibers co-localized with glomus clusters containing tyrosine hydroxylase [15].
Gene_expression (expression) of P2X2 in glomus
19) Confidence 0.53 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.33 Pain Relevance 0.09
Studies have shown the expression of purinoceptor subunits P2X2 and P2X3 in the nerve fibers co-localized with the glomus clusters [15, 31].
Gene_expression (expression) of P2X2 in glomus
20) Confidence 0.53 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.38 Pain Relevance 0

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