INT62962

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Context Info
Confidence 0.08
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.81
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Lpar6) signal transducer activity (Lpar6)
Anatomy Link Frequency
neuronal 1
neurons 1
pituitary 1
DRG 1
microglial cells 1
Lpar6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 58 99.68 Very High Very High Very High
substance P 4 99.32 Very High Very High Very High
agonist 15 97.68 Very High Very High Very High
antagonist 42 96.64 Very High Very High Very High
Kinase C 43 94.52 High High
adenocard 28 85.84 High High
Central nervous system 26 85.72 High High
qutenza 24 82.92 Quite High
IPN 1 82.48 Quite High
Glutamate 20 81.52 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 59 99.68 Very High Very High Very High
Targeted Disruption 15 97.80 Very High Very High Very High
Nociception 11 97.12 Very High Very High Very High
Neurodegenerative Disease 26 93.84 High High
Bone Cancer 43 89.92 High High
Disease 22 73.28 Quite High
Brain Disease 2 73.28 Quite High
Embryonal Carcinoma 14 72.56 Quite High
Cancer 39 66.28 Quite High
INFLAMMATION 17 30.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative data show that kainate-expressing DRG neurons are about six times more likely to express the P2X(3) subunit of the purinergic receptor than to express substance P.
Gene_expression (express) of purinergic receptor in DRG associated with dorsal root ganglion and substance p
1) Confidence 0.08 Published 2006 Journal Pain Section Abstract Doc Link 16360275 Disease Relevance 0.53 Pain Relevance 0.47
Expression of purinergic receptor channels and their role in calcium signaling and hormone release in pituitary gonadotrophs.
Gene_expression (Expression) of purinergic receptor in pituitary
2) Confidence 0.05 Published 1996 Journal J. Biol. Chem. Section Title Doc Link 8702891 Disease Relevance 0 Pain Relevance 0.12
The importance of P2 receptor signaling in neuroprotection, neuroimmunity, and guiding neuronal differentiation, especially in glial and microglial cells, has been related to purinergic receptor expression.
Gene_expression (expression) of purinergic receptor in microglial cells
3) Confidence 0.04 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.23 Pain Relevance 0.23
The use of new techniques such as knockout animals, in vitro models of neuronal differentiation, antisense oligonucleotides to induce downregulation of purinergic receptor gene expression, and the development of selective inhibitors for purinergic receptor subtypes contribute to the comprehension of the role of purinergic signaling during neurogenesis.
Gene_expression (expression) of purinergic receptor in neuronal associated with targeted disruption and neurodegenerative disease
4) Confidence 0.03 Published 2007 Journal Purinergic Signal Section Abstract Doc Link PMC2072925 Disease Relevance 0.26 Pain Relevance 0.12
Among the six LPA receptors, LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6, LPA1 receptor is the main subtype expressed in the DRG neurons [11].
Gene_expression (expressed) of LPA6 in neurons associated with dorsal root ganglion
5) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.78 Pain Relevance 0.87

General Comments

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