INT62979

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Context Info
Confidence 0.25
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.50
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ERG) signal transduction (ERG) nucleus (ERG)
DNA binding (ERG) cytoplasm (ERG) signal transducer activity (ERG)
Anatomy Link Frequency
eye 2
glottis 2
retinas 1
artery 1
pupil 1
ERG (Homo sapiens)
Pain Link Frequency Relevance Heat
Codeine 80 98.32 Very High Very High Very High
Angina 7 89.64 High High
chemokine 2 88.36 High High
qutenza 10 88.08 High High
cytokine 17 86.44 High High
Inflammatory response 6 83.68 Quite High
medulla 24 72.80 Quite High
Inflammation 35 68.68 Quite High
anesthesia 16 66.08 Quite High
cva 2 52.40 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 5 100.00 Very High Very High Very High
Ocular Hypertension 103 99.98 Very High Very High Very High
Muscular Spasm 6 99.22 Very High Very High Very High
Spasticity 5 98.62 Very High Very High Very High
Cough 255 98.28 Very High Very High Very High
Leber Congenital Amaurosis /

Leber Congenital Amaurosis

125 97.24 Very High Very High Very High
Disease 26 95.00 High High
Sprains And Strains 2 91.76 High High
Asthma 33 90.08 High High
Angina 7 89.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The basal coronary artery tone at the spastic and nonspastic sites of spasm related artery was significantly more elevated in Group 1 than that in Group 2 (44 +/- 17 vs 14 +/- 11% and 26 +/- 14 vs 16 +/- 10% respectively, P < 0.05), but not in the nonspasm related artery, The magnitudes of vasoconstrictive responses to Ach and Erg at the nonspastic sites were also greater in Group 1 than those in Group 2 and the control groups (Ach; 40 +/- 20 vs 26 +/- 11, 27 +/- 12%: Erg; 37 +/- 18 vs 12 +/- 8, 13 +/- 10% respectively, P < 0.05).
Positive_regulation (elevated) of Erg in artery associated with spasticity and muscular spasm
1) Confidence 0.25 Published 1996 Journal J. Korean Med. Sci. Section Abstract Doc Link 8703366 Disease Relevance 1.38 Pain Relevance 0.54
We used a mechanical stimulus on the glottis with the thin nylon fiber (diameter 0.2 mm) in order to induce ERg.
Positive_regulation (induce) of ERg in glottis
2) Confidence 0.13 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 0.19 Pain Relevance 0.40
However, we did not find any significant differences in the parameters of ERt (and also ERg) that were induced during inspiration vs. those ERt (ERg) in expiration.
Positive_regulation (induced) of ERg
3) Confidence 0.13 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 0.13 Pain Relevance 0
During ERt (Fig. 1, 2 and 3) or ERg [4,5], only the adductor activation presents as a biphasic response; the PCA is activated in a single short burst.
Positive_regulation (activated) of ERg in adductor
4) Confidence 0.13 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 0.78 Pain Relevance 0.15
No significant differences between the characteristics of ERt or ERg that were induced in expiration vs. inspiration were found.
Positive_regulation (induced) of ERg
5) Confidence 0.13 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 0.14 Pain Relevance 0.17
The expiration reflex mechanically induced from the glottis (ERg) was also analyzed (99.5% incidence, p < 0.001 compared to the incidence of ERt).
Positive_regulation (induced) of ERg in ERg
6) Confidence 0.13 Published 2008 Journal Cough Section Abstract Doc Link PMC2405785 Disease Relevance 0.10 Pain Relevance 0
Normal human retinas respond to increasing stimulus intensity with increased ERG signal amplitude (Figure 4C).
Positive_regulation (increased) of ERG in retinas
7) Confidence 0.12 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1896221 Disease Relevance 0.08 Pain Relevance 0.03
ERG response thresholds were elevated by 3–4 log units (Figure 1C), and the normal reflexive contraction of the pupil in response to light was nearly absent (Figure 1D).
Positive_regulation (elevated) of ERG in pupil
8) Confidence 0.08 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1896221 Disease Relevance 0.07 Pain Relevance 0.03
Among the up-regulated genes were 6 involved in positive regulation of proliferation/differentiation/growth (Kitlg, Runxlt1, Gnaz, Pik3ca, Ptprb, Tmrsf3), 7 associated with increased ubiquitination/apoptosis (Ube3a, Hip2, Casp8ap2, Gmfb, Erg, Pja2, Usp53), and 4 involved in suppression of immune responses (Hgf, Ppapdc2, Rnd3, Dpp4).
Positive_regulation (increased) of Erg associated with apoptosis
9) Confidence 0.07 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 0.62 Pain Relevance 0.16
To study the effect of IOP elevation on the ERG waves in albino mice, simultaneous ERG recordings were performed on the right and left eyes of each animal before surgery.
Positive_regulation (elevation) of ERG in eyes associated with ocular hypertension
10) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.59 Pain Relevance 0
In this study, we used the rd12 mouse to test whether the efficiency of subretinal AAV-RPE65 therapy is altered by a previous intravitreal treatment of the partner eye with the same vector and whether we can restore ERG function in the subretinally treated rd12 eye.


Positive_regulation (restore) of ERG in eye
11) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2633462 Disease Relevance 0.09 Pain Relevance 0

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