INT62981

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.09
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
Anatomy Link Frequency
endothelial cell 1
cleavage 1
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 99.72 Very High Very High Very High
COX2 3 99.72 Very High Very High Very High
cINOD 10 97.64 Very High Very High Very High
cva 2 95.68 Very High Very High Very High
cytokine 1 76.60 Quite High
Pain 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 12 99.16 Very High Very High Very High
Myocardial Infarction 2 96.88 Very High Very High Very High
Cv General 3 Under Development 3 95.68 Very High Very High Very High
Pain 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low
Missed Abortion 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It degrades PGH2 into 12(S)-hydroxy-5(Z), 8(E),10(E)-heptadecatrienoic acid and malondialdehyde rather than converting it to PGE2 [31].
Protein_catabolism (degrades) of PGH2
1) Confidence 0.78 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC3009524 Disease Relevance 0 Pain Relevance 0
Ibuprofen protects human endothelial cell prostaglandin H synthase from hydrogen peroxide.
Protein_catabolism (protects) of prostaglandin H synthase in endothelial cell
2) Confidence 0.61 Published 1996 Journal Am. J. Physiol. Section Title Doc Link 8997188 Disease Relevance 0.09 Pain Relevance 0.09
Site-specific proteolysis of cyclooxygenase-2: a putative step in inflammatory prostaglandin E(2) biosynthesis.
Protein_catabolism (proteolysis) of cyclooxygenase-2 associated with inflammation and cox2
3) Confidence 0.48 Published 2007 Journal J. Cell. Biochem. Section Title Doc Link 17177291 Disease Relevance 0.26 Pain Relevance 0.57
AIM: To assess degree of cyclooxygenase-2 (COX-2) selectivity of a non-steroidal anti-inflammatory drug (NSAID) and risk of myocardial infarction (MI) or cerebrovascular accident (CVA).
Protein_catabolism (degree) of cyclooxygenase-2 associated with inflammation, cinod, cva, cv general 3 under development and myocardial infarction
4) Confidence 0.45 Published 2007 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 17402995 Disease Relevance 0.61 Pain Relevance 0.31
All of the selective PGHS-2 inhibitors protected against tryptic cleavage of apoPGHS-1 but did not inhibit the protein's cyclooxygenase activity.
Protein_catabolism (cleavage) of PGHS-2 in cleavage
5) Confidence 0.08 Published 1996 Journal Biochemistry Section Abstract Doc Link 8703911 Disease Relevance 0.14 Pain Relevance 0.15

General Comments

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