INT62983

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Context Info
Confidence 0.12
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.07
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Aadat) biosynthetic process (Aadat)
Aadat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 3 94.40 High High
Disease Link Frequency Relevance Heat
Mycobacterial Infection 3 96.96 Very High Very High Very High
Pellagra 3 94.52 High High
Neuritis 3 94.40 High High
Syndrome 3 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of kynurenine aminotransferase and the resulting decreased formation of xanthurenic acid generally mean a higher conversion ratio of tryptophan to niacin.
Negative_regulation (inhibition) of kynurenine aminotransferase
1) Confidence 0.12 Published 1996 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 8704317 Disease Relevance 0.33 Pain Relevance 0.08
In vivo inhibition of kynurenine aminotransferase activity by isonicotinic acid hydrazide in rats.
Negative_regulation (inhibition) of kynurenine aminotransferase
2) Confidence 0.09 Published 1996 Journal Biosci. Biotechnol. Biochem. Section Title Doc Link 8704317 Disease Relevance 0.38 Pain Relevance 0.09
The activity of kynurenine aminotransferase was significantly inhibited by feeding a diet containing INH and by an injection of INH, and the urinary excretion of xanthurenic acid, the side-reaction product of the conversion pathway of tryptophan to niacin, was below the limit of detection.
Negative_regulation (inhibited) of kynurenine aminotransferase
3) Confidence 0.09 Published 1996 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 8704317 Disease Relevance 0.37 Pain Relevance 0.09

General Comments

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