INT6299

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Context Info
Confidence 0.61
First Reported 1981
Last Reported 2010
Negated 14
Speculated 26
Reported most in Abstract
Documents 104
Total Number 131
Disease Relevance 8.98
Pain Relevance 48.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pituitary 18
plasma 8
hypothalamus 8
kidney 3
KTP 3
Lhb (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 595 100.00 Very High Very High Very High
Opioid 150 100.00 Very High Very High Very High
Dopamine 116 100.00 Very High Very High Very High
antagonist 112 100.00 Very High Very High Very High
Morphine 110 100.00 Very High Very High Very High
agonist 107 100.00 Very High Very High Very High
Endogenous opioid 102 100.00 Very High Very High Very High
opiate 65 100.00 Very High Very High Very High
opioid receptor 21 100.00 Very High Very High Very High
Central nervous system 15 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 26 100.00 Very High Very High Very High
Precocious Puberty 3 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 100.00 Very High Very High Very High
Stress 26 99.98 Very High Very High Very High
Galactorrhea 11 99.92 Very High Very High Very High
Anovulation 3 99.48 Very High Very High Very High
Eating Disorder 20 99.40 Very High Very High Very High
Polycystic Ovary Syndrome 24 99.04 Very High Very High Very High
Syndrome 6 98.92 Very High Very High Very High
Obesity 3 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of the opiate agonist, morphine, and antagonist, naloxone, on LH release, courtship behavior and ejaculation frequency of mature, sexually active or sexually inactive rams were investigated.
Spec (investigated) Regulation (Effects) of Localization (release) of LH associated with antagonist, narcan, agonist, opiate and morphine
1) Confidence 0.61 Published 1994 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 7956174 Disease Relevance 0 Pain Relevance 0.52
We conclude that endogenous opioid mechanisms are an important inhibitory mechanism controlling pulsatile LH secretion in the developing sheep.
Regulation (controlling) of Localization (secretion) of LH associated with endogenous opioid
2) Confidence 0.60 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0.10 Pain Relevance 0.75
The developing female sheep, which attains puberty after 25 weeks of age, was used as an experimental model to investigate the role of endogenous opioid peptides in the control of pulsatile LH secretion during sexual maturation.
Spec (investigate) Regulation (role) of Localization (secretion) of LH associated with endogenous opioid
3) Confidence 0.60 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0 Pain Relevance 0.39
To assess the role of endogenous dopaminergic tone in the opioid regulation of LH secretion in such patients, LH responses to an opioid antagonist (naloxone) and a dopamine antagonist (metoclopramide) were determined in 11 women with a prolactinoma.
Regulation (role) of Localization (secretion) of LH associated with dopamine, prolactinoma, antagonist, narcan and opioid
4) Confidence 0.60 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3760121 Disease Relevance 0.09 Pain Relevance 0.92
The parallelism in the LH responses to both antagonists in these hyperprolactinemic patients lends further support to a functional link between opioid and dopamine regulation of LH secretion.
Regulation (regulation) of Localization (secretion) of LH associated with dopamine, antagonist and opioid
5) Confidence 0.60 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3760121 Disease Relevance 0.08 Pain Relevance 0.88
The influence of opioid receptors blockade by naloxone on lutropin (LH), follitropin (FSH) and testosterone secretion induced by LH-RH was assessed in 12 male kidney transplant patients with stable graft function (KTP) treated by cyclosporine A and prednisone and in 15 healthy subjects.
Regulation (influence) of in kidney Localization (secretion) of LH in KTP associated with narcan and opioid receptor
6) Confidence 0.60 Published 1992 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 1326100 Disease Relevance 0 Pain Relevance 0.29
[Effect of blockade of opiate receptors by naloxone on lutropin (LH), follitropin (FSH) and testosterone secretion in patients after kidney transplantation].
Regulation (Effect) of Localization (secretion) of LH in kidney associated with narcan and opiate
7) Confidence 0.60 Published 1992 Journal Pol. Arch. Med. Wewn. Section Title Doc Link 1326100 Disease Relevance 0 Pain Relevance 0.46
In the current study, the role of the endogenous opioid system in the regulation of LH release in adult male mice was assessed by testing whether this system is a component of the NMA-stimulated LH response.
Regulation (regulation) of Localization (release) of LH associated with endogenous opioid
8) Confidence 0.60 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8159277 Disease Relevance 0 Pain Relevance 0.72
Effect of naloxone on the secretion of LH in infantile and prepubertal Holstein bull calves.
Regulation (Effect) of Localization (secretion) of LH associated with narcan
9) Confidence 0.60 Published 1990 Journal J. Reprod. Fertil. Section Title Doc Link 2374132 Disease Relevance 0 Pain Relevance 0.47
Secondly, there may be an age-dependent effect of naloxone on LH secretion during seasonal anoestrus in the ewe, with opioids playing a part in the suppression of LH in young but not in mature animals.
Regulation (effect) of Localization (secretion) of LH associated with narcan and opioid
10) Confidence 0.59 Published 1986 Journal J. Reprod. Fertil. Section Abstract Doc Link 3701707 Disease Relevance 0 Pain Relevance 0.55
Opioid modulation of LH secretion in the ewe.
Regulation (modulation) of Localization (secretion) of LH associated with opioid
11) Confidence 0.59 Published 1986 Journal J. Reprod. Fertil. Section Title Doc Link 3701707 Disease Relevance 0 Pain Relevance 0.80
The role of endogenous opiates in the neuroendocrine regulation of episodic LH secretion in normal men was examined in seven adult males before and after the administration of a potent and specific opiate receptor antagonist, naltrexone.
Regulation (regulation) of Localization (secretion) of LH associated with antagonist and opiate
12) Confidence 0.58 Published 1982 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7061693 Disease Relevance 0 Pain Relevance 0.32
To determine whether the nocturnal secretion of LH in early puberty is regulated by endogenous opioid pathways, we determined whether naloxone during the night affected LH secretion or T-mediated suppression of LH secretion.
Spec (whether) Regulation (regulated) of Localization (secretion) of LH associated with precocious puberty, narcan and endogenous opioid
13) Confidence 0.58 Published 1994 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7962287 Disease Relevance 0.10 Pain Relevance 0.27
To determine whether the nocturnal secretion of LH in early puberty is regulated by endogenous opioid pathways, we determined whether naloxone during the night affected LH secretion or T-mediated suppression of LH secretion.
Spec (whether) Regulation (affected) of Localization (secretion) of LH associated with precocious puberty, narcan and endogenous opioid
14) Confidence 0.58 Published 1994 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7962287 Disease Relevance 0.10 Pain Relevance 0.27
The present study was designed to evaluate the influence of hyperandrogenemia on the activity of the opioid system regulating LH secretion in menstruating women.
Regulation (regulating) of Localization (secretion) of LH associated with opioid
15) Confidence 0.57 Published 1987 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 3034748 Disease Relevance 0.25 Pain Relevance 0.32
We studied the activity of endogenous opioid peptides in regulating LH secretion in patients with Turner's syndrome.
Regulation (regulating) of Localization (secretion) of LH associated with syndrome and endogenous opioid
16) Confidence 0.55 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3129445 Disease Relevance 0.17 Pain Relevance 0.26
During anoestrus, the combination of oestradiol-17 beta plus progesterone to ovariectomized ewes reduced the plasma LH concentrations from 3-5 micrograms/l to undetectable levels, and neither saline nor naloxone affected LH secretion.
Neg (neither) Regulation (affected) of Localization (secretion) of LH in plasma associated with narcan
17) Confidence 0.55 Published 1989 Journal J. Endocrinol. Section Abstract Doc Link 2527942 Disease Relevance 0 Pain Relevance 0.38
In these ewes, saline did not alter LH secretion, but naloxone increased LH pulse frequency and the plasma concentrations of LH within 15-20 min.
Neg (not) Regulation (alter) of Localization (secretion) of LH in plasma associated with narcan
18) Confidence 0.55 Published 1989 Journal J. Endocrinol. Section Abstract Doc Link 2527942 Disease Relevance 0 Pain Relevance 0.56
It is probable that the flush is initiated by a supra-pituitary mechanism which is influenced by the hypothalamic factors responsible for pulsatile LH release.
Regulation (responsible) of Localization (release) of LH in pituitary associated with increased venous pressure under development
19) Confidence 0.54 Published 2008 Journal Maturitas Section Abstract Doc Link 18384981 Disease Relevance 0.72 Pain Relevance 0.26
Soay rams were treated with naloxone and/or morphine at different stages of their annual reproductive cycle to study the role of endogenous opioid peptides in the control of pulsatile LH secretion.
Regulation (control) of Localization (secretion) of LH associated with endogenous opioid, narcan and morphine
20) Confidence 0.52 Published 1985 Journal J. Endocrinol. Section Abstract Doc Link 4067489 Disease Relevance 0 Pain Relevance 0.36

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