INT62996

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Context Info
Confidence 0.73
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 1.87
Pain Relevance 8.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnj3)
Anatomy Link Frequency
brain 3
oocytes 2
synapses 1
dorsal horn 1
substantia gelatinosa 1
Kcnj3 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 7 100.00 Very High Very High Very High
Dorsal horn 15 99.92 Very High Very High Very High
analgesia 11 99.80 Very High Very High Very High
Morphine 82 99.40 Very High Very High Very High
substantia gelatinosa 2 99.16 Very High Very High Very High
antagonist 18 99.06 Very High Very High Very High
agonist 12 98.32 Very High Very High Very High
Opioid 30 98.00 Very High Very High Very High
opioid receptor 30 97.56 Very High Very High Very High
Spinal cord 43 96.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 6 98.88 Very High Very High Very High
Targeted Disruption 26 86.96 High High
Drug Dependence 4 77.52 Quite High
Constipation 2 69.96 Quite High
Vomiting 4 69.40 Quite High
Respiratory Failure 2 68.68 Quite High
Hyperalgesia 1 67.36 Quite High
Pain 20 65.44 Quite High
Substance Withdrawal Syndrome 4 32.72 Quite Low
Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We detected GIRK1 (G-protein-gated inwardly rectifying K+ channel subunit 1) and GIRK2 subunits, but not GIRK3, in the superficial layers of the dorsal horn.
Neg (not) Gene_expression (detected) of GIRK1 in dorsal horn associated with dorsal horn
1) Confidence 0.73 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15028774 Disease Relevance 0.73 Pain Relevance 0.86
In regions where GIRK1 and GIRK2 distributions overlap, both GIRK1 and GIRK2 expressions are severely disrupted, probably because of their co-assembly.
Gene_expression (expressions) of GIRK1
2) Confidence 0.69 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8929423 Disease Relevance 0 Pain Relevance 0.52
Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain.
Gene_expression (expression) of GIRK1 in brain
3) Confidence 0.69 Published 1996 Journal J. Neurosci. Section Title Doc Link 8929423 Disease Relevance 0 Pain Relevance 0.57
GIRK1 and GIRK2 were found almost exclusively in postsynaptic membranes of putative excitatory synapses, and a significant degree of overlap with the mu-opioid receptor was observed.
Gene_expression (found) of GIRK1 in synapses associated with opioid receptor
4) Confidence 0.66 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15814785 Disease Relevance 0 Pain Relevance 1.26
All four GIRK subunits are expressed in the brain, and there is a general consensus concerning the expression patterns of GIRK1, GIRK2, and GIRK3.
Gene_expression (expression) of GIRK1 in brain
5) Confidence 0.54 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10908597 Disease Relevance 0 Pain Relevance 0.11
All four GIRK subunits are expressed in the brain, and there is a general consensus concerning the expression patterns of GIRK1, GIRK2, and GIRK3.
Gene_expression (patterns) of GIRK1 in brain
6) Confidence 0.42 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10908597 Disease Relevance 0 Pain Relevance 0.11
This result was observed even when the mutant GIRK2 was coexpressed with GIRK1, a situation more analogous to that seen in vivo.
Gene_expression (coexpressed) of GIRK1
7) Confidence 0.41 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8706831 Disease Relevance 0 Pain Relevance 0.20
Antagonists also activated the G-protein-coupled inwardly rectifying potassium channel 1 (GIRK1) in Xenopus oocytes co-expressing the S196A mutant and the GIRK1 channel.
Gene_expression (rectifying) of GIRK1 in oocytes associated with antagonist and potassium channel
8) Confidence 0.32 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2883971 Disease Relevance 0.57 Pain Relevance 1.60
Antagonists also activated the G-protein-coupled inwardly rectifying potassium channel 1 (GIRK1) in Xenopus oocytes co-expressing the S196A mutant and the GIRK1 channel.
Gene_expression (expressing) of GIRK1 in oocytes associated with antagonist and potassium channel
9) Confidence 0.32 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2883971 Disease Relevance 0.57 Pain Relevance 1.60
We found that the GIRK channel subunits GIRK1 and GIRK2 were concentrated in the outer layer of the substantia gelatinosa of the dorsal horn.
Gene_expression (concentrated) of GIRK1 in substantia gelatinosa associated with substantia gelatinosa and dorsal horn
10) Confidence 0.25 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15814785 Disease Relevance 0 Pain Relevance 1.18

General Comments

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