INT62997

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Context Info
Confidence 0.77
First Reported 1996
Last Reported 2007
Negated 2
Speculated 0
Reported most in Abstract
Documents 17
Total Number 19
Disease Relevance 2.16
Pain Relevance 9.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnj6) Golgi apparatus (Kcnj6) plasma membrane (Kcnj6)
cytoplasm (Kcnj6)
Anatomy Link Frequency
brain 4
oocytes 3
dorsal horn 1
Dopamine neurons 1
neuronal 1
Kcnj6 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 240 100.00 Very High Very High Very High
analgesia 11 99.80 Very High Very High Very High
Dorsal horn 6 99.52 Very High Very High Very High
Dopamine 71 99.50 Very High Very High Very High
Morphine 8 99.40 Very High Very High Very High
fluoxetine 4 99.02 Very High Very High Very High
Spinal cord 11 98.92 Very High Very High Very High
substantia gelatinosa 2 98.92 Very High Very High Very High
sSRI 3 98.80 Very High Very High Very High
agonist 20 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 7 98.88 Very High Very High Very High
Death 18 95.04 Very High Very High Very High
Cv Unclassified Under Development 204 91.64 High High
Stress 57 89.52 High High
Depression 2 77.84 Quite High
Targeted Disruption 37 76.48 Quite High
Parkinson's Disease 348 75.72 Quite High
Hyperalgesia 1 72.88 Quite High
Reperfusion Injury 90 62.88 Quite High
Pain 2 42.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the brain of the wv mouse, GIRK2 expression is decreased dramatically.
Gene_expression (expression) of GIRK2 in brain
1) Confidence 0.77 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8929423 Disease Relevance 0 Pain Relevance 0.55
Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain.
Gene_expression (expression) of GIRK2 in brain
2) Confidence 0.77 Published 1996 Journal J. Neurosci. Section Title Doc Link 8929423 Disease Relevance 0 Pain Relevance 0.57
In regions where GIRK1 and GIRK2 distributions overlap, both GIRK1 and GIRK2 expressions are severely disrupted, probably because of their co-assembly.
Gene_expression (expressions) of GIRK2
3) Confidence 0.77 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8929423 Disease Relevance 0 Pain Relevance 0.52
This result was observed even when the mutant GIRK2 was coexpressed with GIRK1, a situation more analogous to that seen in vivo.
Gene_expression (coexpressed) of GIRK2
4) Confidence 0.73 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8706831 Disease Relevance 0 Pain Relevance 0.20
The resulting increase in basal Na+ permeability causes a marked depolarization of oocytes expressing the mutant GIRK2 protein.
Gene_expression (expressing) of GIRK2 in oocytes
5) Confidence 0.73 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8706831 Disease Relevance 0 Pain Relevance 0.21
GIRK1 and GIRK2 were found almost exclusively in postsynaptic membranes of putative excitatory synapses, and a significant degree of overlap with the mu-opioid receptor was observed.
Gene_expression (found) of GIRK2 in synapses associated with opioid receptor
6) Confidence 0.73 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15814785 Disease Relevance 0 Pain Relevance 1.26
First, we found that a widely used SSRI fluoxetine (also known as Prozac) effectively inhibited wv GIRK2 channels like wild-type GIRK channels, expressed in Xenopus oocytes.
Gene_expression (expressed) of GIRK2 in oocytes associated with ssri and fluoxetine
7) Confidence 0.66 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 16310876 Disease Relevance 0.32 Pain Relevance 0.70
We detected GIRK1 (G-protein-gated inwardly rectifying K+ channel subunit 1) and GIRK2 subunits, but not GIRK3, in the superficial layers of the dorsal horn.
Neg (not) Gene_expression (detected) of GIRK2 in dorsal horn associated with dorsal horn
8) Confidence 0.64 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15028774 Disease Relevance 0.77 Pain Relevance 0.93
We found that the GIRK channel subunits GIRK1 and GIRK2 were concentrated in the outer layer of the substantia gelatinosa of the dorsal horn.
Gene_expression (concentrated) of GIRK2 in substantia gelatinosa associated with substantia gelatinosa and dorsal horn
9) Confidence 0.64 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15814785 Disease Relevance 0 Pain Relevance 1.18
The expression patterns of these GIRK channel subunits provide a basis for consideration of the machinery for neuronal signaling as well as the differential effects of the wv mutation in various neurons.
Gene_expression (expression) of GIRK in neuronal
10) Confidence 0.60 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8929423 Disease Relevance 0 Pain Relevance 0.50
All four GIRK subunits are expressed in the brain, and there is a general consensus concerning the expression patterns of GIRK1, GIRK2, and GIRK3.
Gene_expression (expression) of GIRK2 in brain
11) Confidence 0.56 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10908597 Disease Relevance 0 Pain Relevance 0.11
In the present study, we used Xenopus oocytes to express mutant GIRK2, and to characterize the effects of the mutation on the channel.
Gene_expression (express) of GIRK2 in oocytes
12) Confidence 0.50 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8706831 Disease Relevance 0 Pain Relevance 0.17
All four GIRK subunits are expressed in the brain, and there is a general consensus concerning the expression patterns of GIRK1, GIRK2, and GIRK3.
Gene_expression (patterns) of GIRK2 in brain
13) Confidence 0.44 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10908597 Disease Relevance 0 Pain Relevance 0.11
Previously, we demonstrated that G-protein-gated inwardly rectifying potassium (GIRK) channels are expressed in lamina II of the mouse spinal cord and that pharmacologic ablation of spinal GIRK channels selectively blunts the analgesic effect of high but not lower doses of intrathecal mu-opioid receptor (MOR) agonists.
Gene_expression (expressed) of GIRK in lamina associated with analgesic, agonist, opioid receptor, intrathecal and spinal cord
14) Confidence 0.32 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17122050 Disease Relevance 0 Pain Relevance 0.70
Dopamine neurons lack GIRK1, but express GIRK2 and GIRK3, which when co-assembled have a lower affinity for the ??
Gene_expression (express) of GIRK2 in Dopamine neurons associated with dopamine
15) Confidence 0.24 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1635740 Disease Relevance 0.08 Pain Relevance 0.82
In mice lacking functional KATP channels (SUR1-/-), glucagon secretion in the absence of glucose was lower than that observed in wild-type islets and both glucose (0-20 mmol/l) and the sulfonylureas failed to inhibit glucagon secretion.
Neg (lacking) Gene_expression (lacking) of KATP
16) Confidence 0.15 Published 2004 Journal Diabetes Section Abstract Doc Link 15561909 Disease Relevance 0 Pain Relevance 0.07
Plasma membrane ATP-dependent potassium channels (KATP) are strongly expressed in the heart and have long been associated with cardioprotection [12,157].
Gene_expression (expressed) of KATP in heart associated with potassium channel
17) Confidence 0.04 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.77 Pain Relevance 0.34
However, as noted above (Section 8.3), a major problem associated with such studies is the assumption that the pharmacological agents used are only exerting their effects on the mitochondrial KATP or KCa channels.
Gene_expression (exerting) of KATP associated with potassium channel
18) Confidence 0.04 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.23 Pain Relevance 0.41
Evidence for the mitochondrial KATP channel
Gene_expression (channel) of KATP associated with potassium channel
19) Confidence 0.04 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0 Pain Relevance 0.09

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