INT63005

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Context Info
Confidence 0.36
First Reported 1996
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.07
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pura) cell proliferation (Pura) nucleus (Pura)
DNA binding (Pura) transcription factor binding (Pura) cytoplasm (Pura)
Anatomy Link Frequency
cerebellum 2
Pura (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 5 100.00 Very High Very High Very High
addiction 1 75.00 Quite High
Neuropeptide 2 61.36 Quite High
Disease Link Frequency Relevance Heat
Morphine Dependence 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of ssCRE-BP/Pur alpha and the transcript were not changed by chronic morphine treatment, however, the levels of an activator of ssCRE-BP/Pur alpha, which is necessary for the DNA binding, may be modulated by the treatment.
ssCRE-BP Binding (binding) of associated with morphine
1) Confidence 0.36 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8706895 Disease Relevance 0.07 Pain Relevance 0.30
We have reported that the DNA-binding activity of a single stranded cyclic AMP response element-binding protein (ssCRE-BP) is suppressed in cerebellum treated chronically with morphine, ssCRE-BP is identical to Pur alpha and the DNA binding activity of Pur alpha is markedly enhanced by a heat stable activator in the nuclear extract.
ssCRE-BP Binding (activity) of in cerebellum associated with morphine
2) Confidence 0.05 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10049721 Disease Relevance 0 Pain Relevance 0.13
We have reported that the DNA-binding activity of a single stranded cyclic AMP response element-binding protein (ssCRE-BP) is suppressed in cerebellum treated chronically with morphine, ssCRE-BP is identical to Pur alpha and the DNA binding activity of Pur alpha is markedly enhanced by a heat stable activator in the nuclear extract.
ssCRE-BP Binding (binding) of in cerebellum associated with morphine
3) Confidence 0.05 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10049721 Disease Relevance 0 Pain Relevance 0.13

General Comments

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