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Context Info
Confidence 0.24
First Reported 1996
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Atf6b) nucleus (Atf6b) intracellular (Atf6b)
DNA binding (Atf6b)
Anatomy Link Frequency
brain 1
Atf6b (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 3 99.74 Very High Very High Very High
Locus ceruleus 4 99.68 Very High Very High Very High
Morphine 6 99.16 Very High Very High Very High
addiction 3 84.40 Quite High
withdrawal 5 75.00 Quite High
Ventral tegmentum 3 61.20 Quite High
Raphe 1 58.00 Quite High
amygdala 2 49.36 Quite Low
Nucleus accumbens 2 48.32 Quite Low
Autonomic response 1 40.48 Quite Low
Disease Link Frequency Relevance Heat
Morphine Dependence 2 85.12 High High
Targeted Disruption 1 82.56 Quite High
Opiate Addiction 1 68.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic opiate exposure is associated with upregulation of the cAMP signaling pathway and the transcription factor cAMP response element-binding protein in the locus ceruleus (LC) and certain other brain areas.
cAMP response element-binding protein Binding (associated) of in brain associated with locus ceruleus and opiate
1) Confidence 0.24 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.24 Pain Relevance 0.73
We have purified a nuclear protein from mouse cerebella that binds to single-stranded oligo-DNA of cAMP response element and is modulated by morphine treatment.
cAMP response element Binding (binds) of associated with morphine
2) Confidence 0.10 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8706895 Disease Relevance 0.07 Pain Relevance 0.28

General Comments

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