INT6301

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Context Info
Confidence 0.67
First Reported 1987
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 4.15
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpc6) plasma membrane (Trpc6) transmembrane transport (Trpc6)
Anatomy Link Frequency
diaphragm 1
tail 1
podocyte 1
Trpc6 (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 4 99.96 Very High Very High Very High
tail-flick 1 99.22 Very High Very High Very High
member 8 4 96.00 Very High Very High Very High
Pain 5 95.84 Very High Very High Very High
analgesia 1 94.72 High High
narcan 2 92.96 High High
antagonist 1 92.68 High High
opiate 2 92.24 High High
Dysuria 1 90.80 High High
agonist 4 88.88 High High
Disease Link Frequency Relevance Heat
Prostate Cancer 13 99.28 Very High Very High Very High
Chronic Renal Failure 3 99.20 Very High Very High Very High
Apoptosis 27 98.88 Very High Very High Very High
Nephrotic Syndrome 8 98.56 Very High Very High Very High
Pain 4 95.84 Very High Very High Very High
Recurrence 2 92.04 High High
Adhesions 3 85.12 High High
Disease 11 82.32 Quite High
Catalepsy 1 76.32 Quite High
Proteinuria 2 61.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The protein level of TRPC6 was increased markedly in response to Ang II stimulation, and the intracellular Ca(2+) concentration was elevated.
Positive_regulation (increased) of TRPC6
1) Confidence 0.67 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19546355 Disease Relevance 0.67 Pain Relevance 0.13
TRPC6 up-regulation in Ang II-induced podocyte apoptosis might result from ERK activation and NF-kappaB translocation.
Positive_regulation (up-regulation) of TRPC6 in podocyte associated with apoptosis
2) Confidence 0.45 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Title Doc Link 19546355 Disease Relevance 0.64 Pain Relevance 0.13
In the tail-flick test the latencies were significantly increased after D-Trp-6-LH-RH ICV, both 20 or 40 min after the injections.
Positive_regulation (increased) of D-Trp-6-LH-RH in tail associated with tail-flick and intracerebroventricular
3) Confidence 0.41 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1326115 Disease Relevance 0.08 Pain Relevance 0.80
Notably, TRPC6 has been shown to function in the regulation of calcium influx at the slit diaphragm and increased TRPC channel activity has been associated with reorganization of the actin cytoskeleton.
Positive_regulation (increased) of TRPC6 in diaphragm
4) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.89 Pain Relevance 0.10
These results indicate that the depot formulation of D-TRP-6 LH-RH offers an effective therapeutic alternative for patients with advanced prostatic cancer.
Positive_regulation (formulation) of D-TRP-6 LH-RH associated with prostate cancer
5) Confidence 0.40 Published 1988 Journal Am. J. Clin. Oncol. Section Abstract Doc Link 2977269 Disease Relevance 0.42 Pain Relevance 0.27
The activation of ERK pathway and subsequent translocation of NF-kappaB was possibly necessary for the up-regulation TRPC6 induced by Ang II.
Spec (possibly) Positive_regulation (up-regulation) of TRPC6
6) Confidence 0.39 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19546355 Disease Relevance 0.50 Pain Relevance 0
Long-term results with a long-acting formulation of D-TRP-6 LH-RH in patients with prostate cancer: an Italian prostatic cancer project (P.O.N.CA.P.) study.
Positive_regulation (formulation) of D-TRP-6 LH-RH associated with prostate cancer
7) Confidence 0.16 Published 1987 Journal Prostate Section Title Doc Link 2960957 Disease Relevance 0.36 Pain Relevance 0.07
These results indicate that the depot formulation of D-TRP-6 LH-RH offers an effective therapeutic alternative for patients with advanced prostatic cancer.
Positive_regulation (formulation) of D-TRP-6 LH-RH associated with prostate cancer
8) Confidence 0.16 Published 1987 Journal Prostate Section Abstract Doc Link 2960957 Disease Relevance 0.41 Pain Relevance 0.10
Eight patients had been treated with a depot formulation of the agonist D-Trp-6-LH-RH, with a median remission time of 68 (range 48-102 months).
Positive_regulation (formulation) of D-Trp-6-LH-RH
9) Confidence 0.05 Published 2003 Journal Prostate Section Body Doc Link 12772187 Disease Relevance 0.19 Pain Relevance 0

General Comments

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