INT6302

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Context Info
Confidence 0.48
First Reported 1984
Last Reported 2011
Negated 7
Speculated 3
Reported most in Body
Documents 196
Total Number 204
Disease Relevance 133.85
Pain Relevance 32.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T-cell 7
central nervous system 3
brain 2
nucleus 2
natural killer cell 2
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2329 100.00 Very High Very High Very High
Inflammation 1976 100.00 Very High Very High Very High
Central nervous system 428 100.00 Very High Very High Very High
depression 276 100.00 Very High Very High Very High
dexamethasone 41 100.00 Very High Very High Very High
Opioid 34 100.00 Very High Very High Very High
Paracetamol 619 99.92 Very High Very High Very High
Arthritis 603 99.88 Very High Very High Very High
opioid receptor 14 99.84 Very High Very High Very High
opiate 6 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 2934 100.00 Very High Very High Very High
Infection 2522 100.00 Very High Very High Very High
INFLAMMATION 2113 100.00 Very High Very High Very High
Depression 329 100.00 Very High Very High Very High
Leukemia 58 100.00 Very High Very High Very High
Delirium 26 100.00 Very High Very High Very High
Cancer 1347 99.98 Very High Very High Very High
Autoimmune Disease 232 99.98 Very High Very High Very High
Rhinitis 53 99.98 Very High Very High Very High
Papillomavirus Infection 33 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the group of 100 patients with plantar warts, there was no apparent benefit associated with interferon administration.
interferon Neg (no) Binding (associated) of associated with non-genital cutaneous warts
1) Confidence 0.48 Published 1986 Journal Arch Dermatol Section Abstract Doc Link 3954392 Disease Relevance 0.84 Pain Relevance 0
We conclude that the association of ATRA, DEX and IFN warrants further consideration in MM patients.
IFN Binding (association) of associated with multiple myeloma and dexamethasone
2) Confidence 0.43 Published 1997 Journal Haematologica Section Abstract Doc Link 9234591 Disease Relevance 0.52 Pain Relevance 0.30
Two kinds of IFNalpha mutants were obtained and used to investigate the structural basis of fever of IFNalpha, which are 129Ser-IFNalpha and 38Leu-IFNalpha.
IFNalpha Binding (kinds) of associated with fever
3) Confidence 0.37 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 15465601 Disease Relevance 0.39 Pain Relevance 0.53
We describe a case of retinopathy with swollen optic nerve head (ONH) in a hepatitis C patient treated with combination of interferon and ribavirin.
interferon Binding (combination) of in ONH associated with ocular toxicity (including many sub-types) and hepatitis
4) Confidence 0.37 Published 2008 Journal J Pak Med Assoc Section Abstract Doc Link 18297981 Disease Relevance 0.60 Pain Relevance 0.13
Management of cancer patients receiving interferon alfa-2a.
interferon Binding (receiving) of associated with cancer
5) Confidence 0.37 Published 1987 Journal Int. J. Cancer Suppl. Section Title Doc Link 3476474 Disease Relevance 0.60 Pain Relevance 0.16
Two patients experienced episodes of acute pancreatitis shortly after starting treatment with interferon alfa-2b (IFN-alpha) for a chronic hepatitis C infection.
IFN-alpha Binding (treatment) of associated with chronic hepatitis, pancreatitis and infection
6) Confidence 0.37 Published 2000 Journal Gastroenterology Section Abstract Doc Link 10889173 Disease Relevance 0.66 Pain Relevance 0
Our data imply that IFN-?
IFN Binding (imply) of
7) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 1.09 Pain Relevance 0.68
Combination of IFN beta-1a (Avonex) and mycophenolate mofetil (Cellcept) in multiple sclerosis.
IFN Binding (Combination) of associated with multiple sclerosis
8) Confidence 0.36 Published 2007 Journal Eur. J. Neurol. Section Title Doc Link 17222119 Disease Relevance 0.69 Pain Relevance 0.34
As shown in Figure 3, microglia co-treated with a stimulatory concentration of IFN-?
IFN Binding (concentration) of in microglia
9) Confidence 0.36 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.15 Pain Relevance 0.12
ligand treatment, is associated with decreased IFN-?
IFN Binding (associated) of
10) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.33 Pain Relevance 0.22
in early arthritis which might signify a rethink with regard to timely intervention with IFN-?
IFN Spec (might) Binding (intervention) of associated with arthritis
11) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 1.15 Pain Relevance 0.58
In arthritis, for example, IFN-?
IFN Binding (example) of associated with arthritis
12) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.82 Pain Relevance 0.61
activated RA FLS to degrade intact cartilage matrix and that IFN-?
IFN Binding (matrix) of in cartilage associated with rheumatoid arthritis
13) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 1.06 Pain Relevance 0.74
PURPOSE: A phase I/II study of oral all-trans-retinoic acid (ATRA; tretinoin), administered every other week alone and then in combination with interferon (IFN) alfa-2a, was undertaken to evaluate the activity, toxicity, and pharmacokinetics of this regimen in patients with human immunodeficiency virus (HIV)-associated Kaposi's sarcoma (KS).
IFN Binding (combination) of associated with sarcoma, toxicity and acquired immune deficiency syndrome or hiv infection
14) Confidence 0.36 Published 1995 Journal J. Clin. Oncol. Section Abstract Doc Link 7636537 Disease Relevance 0.46 Pain Relevance 0
Similar findings have been reported for interferon-alpha (IFN-alpha), a peptide associated with the immune response to virus.
IFN Binding (associated) of
15) Confidence 0.35 Published 1988 Journal J. Neurosci. Res. Section Abstract Doc Link 3343705 Disease Relevance 0.08 Pain Relevance 0.47
Twenty-four patients with human papillomavirus (HPV)-associated cervical intraepithelial neoplasia (CIN); of whom 13 had CIN 1, 8 had CIN 2, and 3 had CIN 3; were treated with recombinant alpha 2b interferon (IFN) by intraperilesional injections.
IFN Binding (treated) of associated with papillomavirus infection and cervical intraepithelial neoplasia
16) Confidence 0.34 Published 1992 Journal Sex Transm Dis Section Abstract Doc Link 1326126 Disease Relevance 1.28 Pain Relevance 0.06
Bevacizumab plus IFN is well tolerated, with dose reduction of IFN providing the flexibility to improve tolerability further.
IFN Binding (Bevacizumab) of
17) Confidence 0.34 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721410 Disease Relevance 1.00 Pain Relevance 0
Both AVOREN and CALGB 90206 show that bevacizumab plus IFN produces significant clinical benefit as first-line therapy for patients with metastatic RCC.
IFN Binding (bevacizumab) of associated with renal cancer
18) Confidence 0.34 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721410 Disease Relevance 0.48 Pain Relevance 0
TORAVA, a French phase II trial, is ongoing and will compare sunitinib with bevacizumab plus IFN and bevacizumab plus temsirolimus.
IFN Binding (compare) of
19) Confidence 0.34 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721410 Disease Relevance 0.46 Pain Relevance 0
The dose intensity of IFN was lower in patients with low CLcr (IFN plus placebo 92%; bevacizumab plus IFN 78%) and ?
IFN Binding (intensity) of
20) Confidence 0.34 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721410 Disease Relevance 0.44 Pain Relevance 0.04

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