INT63024

Context Info Confidence 0.49 First Reported 1995 Last Reported 1998 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 1.28 Pain Relevance 0.71

nucleus (BHLHE22)

Anatomy Link Frequency platelet 2 ECM 2 BHLHE22 (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 8 97.84 aspirin 1 97.28 antagonist 1 72.48 Percutaneous transluminal coronary angioplasty 1 66.56 Angina 1 59.44 Inflammation 1 34.00

Disease Link Frequency Relevance Heat Adenocarcinoma 7 98.48 Pancreatitis 8 97.84 Acute Coronary Syndrome 1 96.48 Thrombosis 1 91.60 Syndrome 1 75.00 Carcinoma 2 63.60 Malignant Neoplastic Disease 1 5.00 Cv General 3 Under Development 1 5.00 INFLAMMATION 1 5.00 Myocardial Infarction 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Expression of nine alpha-subunits (alpha 2-alpha 6, alpha V, alpha L, alpha M, and alpha X), four beta-subunits (beta 1, beta 3-beta 5), and four ECM molecules (type IV collagen, laminin, fibronectin, and vitronectin) was investigated immunohistochemically.

Spec (investigated) Positive_regulation (investigated) of Spec (investigated) Gene_expression (Expression) of beta 3 in ECM

1) Confidence 0.49 Published 1995 Journal Int. J. Pancreatol. Section Abstract Doc Link 8708394 Disease Relevance 1.01 Pain Relevance 0.53

The discovery of the platelet integrin receptor alpha(IIb)beta3, also known as the platelet glycoprotein (GP) IIb-IIIa receptor, is a breakthrough in antiplatelet therapy.

Positive_regulation (discovery) of Gene_expression (discovery) of beta3 in platelet

2) Confidence 0.49 Published 1998 Journal Pharmacotherapy Section Abstract Doc Link 9692642 Disease Relevance 0.26 Pain Relevance 0.18

General Comments

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