INT63025

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 3.79
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (BHLHE22)
Anatomy Link Frequency
sensory neurons 2
nerves 1
arms 1
platelet 1
ECM 1
BHLHE22 (Homo sapiens)
BHLHE22 - C825T (1)
Pain Link Frequency Relevance Heat
sodium channel 14 100.00 Very High Very High Very High
metalloproteinase 2 98.64 Very High Very High Very High
addiction 2 97.76 Very High Very High Very High
nav1.8 6 97.72 Very High Very High Very High
aspirin 1 97.28 Very High Very High Very High
Chronic pancreatitis 9 97.08 Very High Very High Very High
Pain 3 95.76 Very High Very High Very High
fibrosis 1 95.04 Very High Very High Very High
IPN 4 93.00 High High
Neurotransmitter 1 91.20 High High
Disease Link Frequency Relevance Heat
Adhesions 3 100.00 Very High Very High Very High
Obesity 3 99.84 Very High Very High Very High
Cancer 1 99.48 Very High Very High Very High
Injury 6 99.44 Very High Very High Very High
Hypertension 6 98.60 Very High Very High Very High
Adenocarcinoma 7 98.48 Very High Very High Very High
Pancreatitis 10 98.24 Very High Very High Very High
Acute Coronary Syndrome 1 96.48 Very High Very High Very High
Pain 3 95.76 Very High Very High Very High
Fibrosis 1 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of nine alpha-subunits (alpha 2-alpha 6, alpha V, alpha L, alpha M, and alpha X), four beta-subunits (beta 1, beta 3-beta 5), and four ECM molecules (type IV collagen, laminin, fibronectin, and vitronectin) was investigated immunohistochemically.
Spec (investigated) Gene_expression (Expression) of beta 3 in ECM
1) Confidence 0.75 Published 1995 Journal Int. J. Pancreatol. Section Abstract Doc Link 8708394 Disease Relevance 0.96 Pain Relevance 0.50
Atypical beta-adrenoceptors or beta3-adrenoceptors, which are present on adipocytes, have been demonstrated pharmacologically.
Gene_expression (present) of beta3 in adipocytes associated with obesity
2) Confidence 0.65 Published 1998 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 9551698 Disease Relevance 0.43 Pain Relevance 0.23
The discovery of the platelet integrin receptor alpha(IIb)beta3, also known as the platelet glycoprotein (GP) IIb-IIIa receptor, is a breakthrough in antiplatelet therapy.
Gene_expression (discovery) of beta3 in platelet
3) Confidence 0.65 Published 1998 Journal Pharmacotherapy Section Abstract Doc Link 9692642 Disease Relevance 0.26 Pain Relevance 0.18
[C825T polymorphism of the GNB3 gene codifying the G-protein beta3-subunit and cardiovascular risk].
Gene_expression (codifying) of beta3 (C825T)
4) Confidence 0.65 Published 2004 Journal Ann. Ital. Med. Int. Section Title Doc Link 15678704 Disease Relevance 0.80 Pain Relevance 0.06
Expression of the sodium channel beta3 subunit in injured human sensory neurons.
Gene_expression (Expression) of beta3 in sensory neurons associated with sodium channel
5) Confidence 0.55 Published 2004 Journal Neuroreport Section Title Doc Link 15232296 Disease Relevance 0.26 Pain Relevance 0.46
Coexpression of beta1 or beta3 did not affect inactivation time course or the voltage dependence of activation, but shifted the inactivation curve approximately 10 mV negative, and slowed the repriming rate ca. three-fold. beta2 did not affect channel properties, either by itself or in combination with beta1 or beta3.
Gene_expression (Coexpression) of beta3 associated with addiction
6) Confidence 0.51 Published 2002 Journal Neuroscience Section Abstract Doc Link 12220575 Disease Relevance 0.07 Pain Relevance 0.31
Excitable cells express multiple alpha subtypes, designated Na(v)1.1-Na(v)1.9, and three beta subunits, designated beta1, beta2 and beta3.
Gene_expression (express) of beta3
7) Confidence 0.51 Published 2002 Journal Neuroscience Section Abstract Doc Link 12220575 Disease Relevance 0 Pain Relevance 0.25
Unlike beta1- and beta2, beta3-immunoreactivity did not decrease after avulsion injury, and the beta3:neurofilament ratio was significantly increased in proximal injured human nerves. beta3-subunit expression may thus be regulated differently from beta1, beta2 and Nav1.8.
Gene_expression (expression) of beta3 in nerves associated with injury and nav1.8
8) Confidence 0.48 Published 2004 Journal Neuroreport Section Abstract Doc Link 15232296 Disease Relevance 0.26 Pain Relevance 0.51
We have now detected, by immunohistochemistry, beta3-subunits in 82% of small/medium and 67% of large diameter sensory neurons in intact human dorsal root ganglia: 54% of beta3 small/medium neurons were NGF receptor trkA negative.
Gene_expression (detected) of beta3 in sensory neurons
9) Confidence 0.42 Published 2004 Journal Neuroreport Section Abstract Doc Link 15232296 Disease Relevance 0.27 Pain Relevance 0.41
To investigate beta1 and beta3 containing integrin-mediated adhesion and subsequent MMP-2/-9 protein and gene expression in human blood-derived monocytes, biofunctional peptides immobilized onto flexible polyethylene glycol (PEG) arms were grafted onto a gelatin-based interpenetrating network (IPN).
Gene_expression (expression) of beta3 in arms associated with ipn and adhesions
10) Confidence 0.16 Published 2007 Journal Biomaterials Section Abstract Doc Link 16979234 Disease Relevance 0.17 Pain Relevance 0.25
Expression of transforming growth factor beta1, beta2, and beta3 in chronic, cancer-associated, obstructive pancreatitis.
Gene_expression (Expression) of beta3 associated with cancer and pancreatitis
11) Confidence 0.13 Published 2006 Journal Arch. Pathol. Lab. Med. Section Title Doc Link 16519564 Disease Relevance 0.29 Pain Relevance 0.14

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