INT63035

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Context Info
Confidence 0.56
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 16
Disease Relevance 11.56
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (CSTA) nucleus (CSTA) intracellular (CSTA)
protein binding, bridging (CSTA) cytoplasm (CSTA)
Anatomy Link Frequency
plasma 1
tear 1
cerebrospinal fluid 1
muscle 1
saliva 1
CSTA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 65 99.04 Very High Very High Very High
rheumatoid arthritis 14 74.08 Quite High
Pain 2 38.16 Quite Low
Arthritis 7 27.72 Quite Low
cINOD 14 5.00 Very Low Very Low Very Low
Migraine 7 5.00 Very Low Very Low Very Low
Multiple sclerosis 7 5.00 Very Low Very Low Very Low
cva 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 840 99.84 Very High Very High Very High
Crystal Associated Disease 231 99.32 Very High Very High Very High
Disorders Of Creatine Metabolism 126 99.16 Very High Very High Very High
INFLAMMATION 72 99.04 Very High Very High Very High
Neuropathy 35 98.84 Very High Very High Very High
Rheumatic Diseases 35 98.12 Very High Very High Very High
Disease 378 97.68 Very High Very High Very High
Disease Progression 196 94.36 High High
Renal Disease 133 93.20 High High
Disorder Of Lipid Metabolism 56 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cystatins S, SA, SN, and D are only found in glandular saliva and tear fluid whereas cystatin C has been detected in all tested biological fluids.
Gene_expression (detected) of cystatin in tear
1) Confidence 0.56 Published 1996 Journal J. Periodontol. Section Abstract Doc Link 8708950 Disease Relevance 0.31 Pain Relevance 0.04
Cystatins S, SA, SN, and D are only found in glandular saliva and tear fluid whereas cystatin C has been detected in all tested biological fluids.
Gene_expression (detected) of cystatin in saliva
2) Confidence 0.19 Published 1996 Journal J. Periodontol. Section Abstract Doc Link 8708950 Disease Relevance 0.31 Pain Relevance 0.04
It has long been known that cystatin C levels are not highly influenced by confounding factors, such as diet, nutrition, or inflammatory status, whereas measurements for GFR based on creatinine levels, including the MDRD or C&G formulas, have substantial limitations such as age, sex, muscle mass, ethnicity, and methodology of determining serum creatinine level (1) However, cystatin C production was not thought to be affected by any factors until several authors demonstrated that serum cystatin C could be affected by both rheumatoid factor (22) and high doses of glucocorticoid (23).
Gene_expression (production) of cystatin in muscle associated with inflammation
3) Confidence 0.08 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 0.33 Pain Relevance 0.08
In the present study, we assessed whether certain demographic and clinical factors were correlated with serum cystatin C levels among all enrolled patients.
Gene_expression (levels) of cystatin
4) Confidence 0.07 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 0.53 Pain Relevance 0.08
Additionally, indirect evidence, including decreasing cystatin C in asthmathic patients after cyclosporine therapy (24) and the positive correlation between CRP and cystatin C levels in large populations indicates that inflammatory status may also contribute to changes in serum cystatin C levels (25).
Gene_expression (levels) of cystatin associated with inflammation
5) Confidence 0.07 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 0.50 Pain Relevance 0.09
The degree of agglutination between latex particles coated with antibodies specific for human cystatin C and serum cystatin C levels is closely correlated with the concentration of cystatin C in the sample.
Gene_expression (levels) of cystatin
6) Confidence 0.07 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 0.55 Pain Relevance 0
Additionally, indirect evidence, including decreasing cystatin C in asthmathic patients after cyclosporine therapy (24) and the positive correlation between CRP and cystatin C levels in large populations indicates that inflammatory status may also contribute to changes in serum cystatin C levels (25).
Gene_expression (levels) of cystatin associated with inflammation
7) Confidence 0.07 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 0.52 Pain Relevance 0.08
Analysis for linear associations showed that reciprocal cystatin C levels correlate well with Ccr of 24 hr urine (r=0.702).
Gene_expression (levels) of cystatin in urine associated with disorders of creatine metabolism
8) Confidence 0.07 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 1.27 Pain Relevance 0
This is the first study to demonstrate the clinical application of serum cystatin C levels in the field of gout, one of the inflammatory rheumatic diseases.
Gene_expression (levels) of cystatin associated with inflammation, crystal associated disease and rheumatic diseases
9) Confidence 0.06 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 1.12 Pain Relevance 0.12
Furthermore, the absence of a relationship between cystatin C levels in concurrently-drawn CSF and plasma samples from individual patients in this study (Figure S2) suggests that this protein is independently regulated in each biofluid.
Gene_expression (levels) of cystatin in plasma
10) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 1.09 Pain Relevance 0.04
These results indicate that CSF cystatin C levels in ALS patients change over time in a clinically-relevant manner and that increasing cystatin C concentration may be associated with slower disease progression.
Gene_expression (levels) of cystatin associated with disease progression and motor neuron diseases
11) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.68 Pain Relevance 0
A recent study reported a significant reduction in CSF cystatin C levels in ALS patients relative to polyneuropathy patients [16].
Gene_expression (levels) of cystatin associated with neuropathy and motor neuron diseases
12) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.99 Pain Relevance 0
In our current ELISA study for diagnostic utility using a much larger number of total subjects, we also found a significant reduction in cystatin C levels in the CSF of ALS patients relative to healthy controls, but the magnitude of this difference was less robust than in the previous reports.
Gene_expression (levels) of cystatin associated with motor neuron diseases
13) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.52 Pain Relevance 0
To explore the relationship between CSF cystatin C levels measured by these two techniques, we compared our ELISA results with SELDI-TOF-MS data for the same CSF samples.
Gene_expression (levels) of cystatin
14) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.66 Pain Relevance 0
Two prior surface-enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS) studies reported significant decreases in CSF cystatin C levels in ALS patients relative to healthy controls [6] and mixed healthy/neurologic disease controls [7].
Gene_expression (levels) of cystatin associated with disease and motor neuron diseases
15) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 1.04 Pain Relevance 0
We used quantitative enzyme-linked immunosorbent assay (ELISA) to assess initial and longitudinal cerebrospinal fluid (CSF) and plasma cystatin C levels in 104 ALS patients and controls.
Gene_expression (levels) of cystatin in cerebrospinal fluid associated with motor neuron diseases
16) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3000338 Disease Relevance 1.16 Pain Relevance 0

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