INT63037

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Context Info
Confidence 0.37
First Reported 1996
Last Reported 2010
Negated 5
Speculated 3
Reported most in Body
Documents 10
Total Number 23
Disease Relevance 13.37
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (CSTA) nucleus (CSTA) intracellular (CSTA)
protein binding, bridging (CSTA) cytoplasm (CSTA)
Anatomy Link Frequency
muscle 2
saliva 2
CSF 1
epididymis 1
CSTA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 81 99.38 Very High Very High Very High
rheumatoid arthritis 16 94.72 High High
Pain 3 81.40 Quite High
medulla 2 49.80 Quite Low
cINOD 16 5.00 Very Low Very Low Very Low
Migraine 11 5.00 Very Low Very Low Very Low
Multiple sclerosis 11 5.00 Very Low Very Low Very Low
cva 11 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 1320 99.48 Very High Very High Very High
Crystal Associated Disease 264 99.48 Very High Very High Very High
INFLAMMATION 89 99.38 Very High Very High Very High
Disease Progression 308 98.40 Very High Very High Very High
Disease 570 97.84 Very High Very High Very High
Disorders Of Creatine Metabolism 144 97.36 Very High Very High Very High
Periodontitis 6 96.24 Very High Very High Very High
Salivary Gland Disease 6 96.20 Very High Very High Very High
Rheumatoid Arthritis 16 94.72 High High
Rheumatic Diseases 40 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, concentrations of cystatin S were unchanged during the periodontal treatment process.
Neg (unchanged) Regulation (unchanged) of cystatin
1) Confidence 0.37 Published 1996 Journal J. Periodontol. Section Abstract Doc Link 8708950 Disease Relevance 0.42 Pain Relevance 0.11
Based on these results we studied a possible change in the concentration of cystatin S, cystatin C, albumin, IgA, amylase activity, and cystatin activity in a whole and parotid saliva of 20 periodontitis patients as a consequence of periodontal treatment.
Spec (possible) Regulation (change) of cystatin in saliva associated with periodontitis
2) Confidence 0.37 Published 1996 Journal J. Periodontol. Section Abstract Doc Link 8708950 Disease Relevance 0.45 Pain Relevance 0.12
Based on these results we studied a possible change in the concentration of cystatin S, cystatin C, albumin, IgA, amylase activity, and cystatin activity in a whole and parotid saliva of 20 periodontitis patients as a consequence of periodontal treatment.
Spec (possible) Regulation (change) of cystatin in saliva associated with periodontitis
3) Confidence 0.37 Published 1996 Journal J. Periodontol. Section Abstract Doc Link 8708950 Disease Relevance 0.45 Pain Relevance 0.12
This maintenance of similar LCN6 mRNA concentrations under the three treatment conditions contrasts with the androgen regulation of human epididymal (HE) protein 2 [29], epididymis specific clone (ESC) 42 [30] and cystatin (CST) 11 [57] we previously reported in this same experiment.
Regulation (regulation) of cystatin in epididymis
4) Confidence 0.05 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.05 Pain Relevance 0
It has long been known that cystatin C levels are not highly influenced by confounding factors, such as diet, nutrition, or inflammatory status, whereas measurements for GFR based on creatinine levels, including the MDRD or C&G formulas, have substantial limitations such as age, sex, muscle mass, ethnicity, and methodology of determining serum creatinine level (1) However, cystatin C production was not thought to be affected by any factors until several authors demonstrated that serum cystatin C could be affected by both rheumatoid factor (22) and high doses of glucocorticoid (23).
Neg (not) Regulation (influenced) of cystatin in muscle associated with inflammation
5) Confidence 0.05 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 0.29 Pain Relevance 0.05
Using serum cystatin C levels has some advantages over serum creatinine and creatinine-based calculated GFR formulas, in that serum cystatin C levels are independent of age, gender, muscle mass, and renal tubular secretion (1).
Neg (independent) Regulation (independent) of cystatin in muscle
6) Confidence 0.03 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 0.38 Pain Relevance 0.03
To conclusively determine the diagnostic value of serum cystatin C levels for monitoring renal function of gouty patients, further prospective studies in a larger study population are needed.



Spec (determine) Regulation (value) of cystatin
7) Confidence 0.03 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 0.84 Pain Relevance 0.14
Diagnostic efficacy of serum cystatin C levels was evaluated through non-parametric receiver operating characteristic (ROC) analysis.
Regulation (efficacy) of cystatin
8) Confidence 0.03 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2800003 Disease Relevance 0.46 Pain Relevance 0
Additionally, indirect evidence, including decreasing cystatin C in asthmathic patients after cyclosporine therapy (24) and the positive correlation between CRP and cystatin C levels in large populations indicates that inflammatory status may also contribute to changes in serum cystatin C levels (25).
Regulation (changes) of cystatin associated with inflammation
9) Confidence 0.03 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 0.52 Pain Relevance 0.09
The risk factors for changes in serum cystatin C levels were confirmed using multivariate regression analysis.
Regulation (changes) of cystatin
10) Confidence 0.03 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2800003 Disease Relevance 0.50 Pain Relevance 0
The characteristics or patterns of changes of serum cystatin C level were not observed in this study because of limitation of cross-sectional study.
Regulation (changes) of cystatin
11) Confidence 0.03 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 1.23 Pain Relevance 0.18
We investigated the diagnostic efficacy of serum cystatin C compared to that of serum creatinine levels and identified the relating factors associated with changes in serum cystatin C levels in gout patients with renal impairment.
Regulation (changes) of cystatin associated with crystal associated disease
12) Confidence 0.03 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2800003 Disease Relevance 0.37 Pain Relevance 0
A recent study examined a single CSF draw per ALS patient, taken at varying times from symptom onset, to indirectly infer the average longitudinal change in cystatin C concentration in the group as a whole, and they reported that cystatin C levels do not change over time [16].
Neg (not) Regulation (change) of cystatin associated with motor neuron diseases
13) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 1.16 Pain Relevance 0.04
The effect of time on longitudinal cystatin C levels in ALS patients with multiple biofluid draws was assessed with SPSS software, using the general linear model for repeated measures.
Regulation (effect) of cystatin associated with motor neuron diseases
14) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.10 Pain Relevance 0
In addition, the direction of longitudinal change in CSF cystatin C levels correlated to the rate of ALS disease progression, and initial CSF cystatin C levels were predictive of patient survival, suggesting that cystatin C may function as a surrogate marker of disease progression and survival.
Regulation (change) of cystatin in CSF associated with disease progression and motor neuron diseases
15) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3000338 Disease Relevance 1.24 Pain Relevance 0
For comparison, we also assessed the longitudinal change in CSF cystatin C levels in 10 healthy controls, each with two CSF samples drawn 1.5–2 years apart.
Regulation (change) of cystatin
16) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.17 Pain Relevance 0
A repeated measures t-test revealed a modest increase in total cystatin C concentration over time in these healthy controls but no longitudinal change in percent cystatin C levels (data not shown).


Neg (no) Regulation (change) of cystatin
17) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.05 Pain Relevance 0
We also conducted an analysis to determine the relationship between longitudinal changes in CSF cystatin C levels and time-matched changes in three functional clinical measures of disease progression (ALSFRS-R, MMT, and FVC).
Regulation (changes) of cystatin associated with disease progression
18) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.69 Pain Relevance 0
Additionally, longitudinal changes in CSF cystatin C levels may be useful as a biomarker of fast versus slow rates of disease progression.
Regulation (changes) of cystatin associated with disease progression
19) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.79 Pain Relevance 0
To explore the relationship between CSF cystatin C levels measured by these two techniques, we compared our ELISA results with SELDI-TOF-MS data for the same CSF samples.
Regulation (measured) of cystatin
20) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.66 Pain Relevance 0

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