INT63042

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Context Info
Confidence 0.48
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 59
Total Number 61
Disease Relevance 31.23
Pain Relevance 5.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
macrophages 4
astrocyte 3
Neurons 2
plasma 1
hepatocytes 1
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 400 99.98 Very High Very High Very High
Thalamus 37 99.92 Very High Very High Very High
Inflammation 423 99.88 Very High Very High Very High
addiction 18 99.84 Very High Very High Very High
Central nervous system 167 99.52 Very High Very High Very High
Inflammatory response 25 98.36 Very High Very High Very High
Peripheral nervous system 40 97.16 Very High Very High Very High
dexamethasone 368 94.00 High High
Neuritis 154 93.80 High High
antagonist 27 93.12 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 790 100.00 Very High Very High Very High
Hyperlipidemia 104 100.00 Very High Very High Very High
Syndrome 143 99.92 Very High Very High Very High
Targeted Disruption 1046 99.88 Very High Very High Very High
INFLAMMATION 491 99.88 Very High Very High Very High
Disease 2120 99.72 Very High Very High Very High
Dementia 178 98.84 Very High Very High Very High
Amyloid Plaque 266 98.40 Very High Very High Very High
Neurological Disease 7 97.80 Very High Very High Very High
Injury 39 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apolipoprotein E (apoE) is associated with familial and sporadic Alzheimer's disease (AD).
apoE Binding (associated) of associated with disease and disorder of lipid metabolism
1) Confidence 0.48 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8710189 Disease Relevance 0.98 Pain Relevance 0.07
Apolipoprotein E (apoE) is associated with familial and sporadic Alzheimer's disease (AD).
Apolipoprotein E Binding (associated) of associated with disease and disorder of lipid metabolism
2) Confidence 0.48 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8710189 Disease Relevance 0.98 Pain Relevance 0.07
It is likely that the low nerve fiber density and the low percent neural tissue associated with apo E-deficiency result from impairment in the disposal of myelin debris.
apo E Binding (associated) of in neural
3) Confidence 0.48 Published 2002 Journal J Reconstr Microsurg Section Abstract Doc Link 12177820 Disease Relevance 0.28 Pain Relevance 0.12
ApoE can bind lipopolysaccharide (LPS), attenuate the inflammatory response, and thus reduce LPS induced lethality [53].
ApoE Binding (bind) of associated with inflammatory response
4) Confidence 0.48 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.88 Pain Relevance 0.14
Alternatively, apoE can act by binding to cell surface receptors.
apoE Binding (binding) of
5) Confidence 0.48 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.66 Pain Relevance 0.25
Importantly, the risk associated with APOE-?
APOE Binding (associated) of
6) Confidence 0.47 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 1.08 Pain Relevance 0.06
Of the two major apolipoproteins found in the CSF, apoE can associate to a number of extracellular molecules and bind to four major CNS apoE receptors; VLDLR, ApoER2, LDLR and LRP.
apoE Binding (associate) of
7) Confidence 0.47 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.55 Pain Relevance 0.14
Thus, the interactions of apoE complexes with the apoE receptors in the CNS vitally affect not only the metabolism of apoE, but of A?
apoE Binding (interactions) of
8) Confidence 0.47 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.51 Pain Relevance 0
Thus, the interactions of apoE complexes with the apoE receptors in the CNS vitally affect not only the metabolism of apoE, but of A?
apoE Binding (complexes) of
9) Confidence 0.47 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.50 Pain Relevance 0
ApoE binds soluble A?
ApoE Binding (binds) of
10) Confidence 0.47 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 1.29 Pain Relevance 0
Treatment of microglia and peripheral macrophages with apoE could increase NO production stimulated by IFN-?
apoE Binding (macrophages) of in microglia
11) Confidence 0.37 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.37 Pain Relevance 0.10
Macrophages of apoE-deficient mice stimulated by exogenous antigen are more effective in the upregulating of main histocompatibility complex (MHC) class II molecules and costimulatory molecules like CD40 and CD80, with increased IFN-?
apoE Binding (Macrophages) of in Macrophages
12) Confidence 0.37 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.37 Pain Relevance 0.05
SZM and CS were blinded to APOE and treatment (LPS or saline) of each section.
APOE Binding (blinded) of
13) Confidence 0.37 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0 Pain Relevance 0.18
Apolipoprotein E (ApoE), a 34 kDa glycosylated protein with multiple biological properties, has been linked both with the innate immune response of mice and with neurological disease.
Apolipoprotein E Binding (linked) of associated with neurological disease and disorder of lipid metabolism
14) Confidence 0.37 Published 2004 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 14989598 Disease Relevance 1.15 Pain Relevance 0.63
Apolipoprotein E (ApoE), a 34 kDa glycosylated protein with multiple biological properties, has been linked both with the innate immune response of mice and with neurological disease.
ApoE Binding (linked) of associated with neurological disease and disorder of lipid metabolism
15) Confidence 0.37 Published 2004 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 14989598 Disease Relevance 1.15 Pain Relevance 0.63
ApoE receptors undergo rapid clathrin-mediated endocytosis following ligand binding and have the ability to link ligand binding to several signal transduction pathways.
ApoE Binding (binding) of
16) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.73 Pain Relevance 0.08
Of the two major apolipoproteins found in the CSF, apoE can associate to a number of extracellular molecules and bind to four major CNS apoE receptors; VLDLR, ApoER2, LDLR and LRP.
apoE Binding (bind) of
17) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.55 Pain Relevance 0.14
Since then, apoE receptors have been found to help transport A?
apoE Binding (receptors) of
18) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.61 Pain Relevance 0
ApoE receptors undergo rapid clathrin-mediated endocytosis following ligand binding and have the ability to link ligand binding to several signal transduction pathways.
ApoE Binding (binding) of
19) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.75 Pain Relevance 0.08
ApoE, the major serum factor that binds lipids, could efficiently bind lipid antigens and dramatically facilitate their presentation by CD1b, CD1c and CD1d molecules via the binding to LDLR [33, 104].
ApoE Binding (binds) of
20) Confidence 0.36 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.25 Pain Relevance 0.06

General Comments

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