INT63043

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Context Info
Confidence 0.48
First Reported 1996
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.75
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBG2) transport (HBG2)
Anatomy Link Frequency
body 2
HBG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 7 87.00 High High
Central nervous system 1 83.20 Quite High
headache 4 80.24 Quite High
tolerance 2 69.52 Quite High
lidocaine 4 64.76 Quite High
cva 10 46.00 Quite Low
Antihistamine 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Methemoglobinemia 41 99.40 Very High Very High Very High
Hypoxia 4 98.32 Very High Very High Very High
Sickle Cell Anemia 46 92.64 High High
Reperfusion Injury 2 87.76 High High
Cv Unclassified Under Development 7 87.00 High High
Acute Chest Syndrome 35 85.84 High High
Stress 11 80.52 Quite High
Toxicity 24 63.00 Quite High
Reprotox - General 3 4 59.60 Quite High
Pregnancy Complications 8 57.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the beta estimate from the multi-variable regression assessment of methemoglobin levels at 36 weeks was suggestive of higher methemoglobin levels among pregnant women with higher estimated nitrate intake from tap water, it was not statistically significant (?
Spec (suggestive) Positive_regulation (suggestive) of Gene_expression (levels) of methemoglobin
1) Confidence 0.48 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0
The current study result of decreasing methemoglobin levels during pregnancy did not support the a priori hypothesis that methemoglobin levels increase during pregnancy in populations exposed to nitrates in drinking water.
Positive_regulation (increase) of Gene_expression (levels) of methemoglobin
2) Confidence 0.48 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.05 Pain Relevance 0
Methemoglobin levels at 36 weeks gestation were higher among women with intermediate range of tap water nitrate levels compared to women with ?
Positive_regulation (higher) of Gene_expression (levels) of Methemoglobin
3) Confidence 0.48 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0
Subclinical increases in methemoglobin levels may occur in populations exposed to low levels of nitrates in drinking water; however, methemoglobin levels in these populations have not been well characterized.
Positive_regulation (increases) of Gene_expression (levels) of methemoglobin
4) Confidence 0.48 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.49 Pain Relevance 0.06
However, the elevated levels of methemoglobin and lactates indicate a slight degree of oxygen deficiency in the body.
Positive_regulation (elevated) of Gene_expression (levels) of methemoglobin in body associated with hypoxia
5) Confidence 0.46 Published 1996 Journal Prz. Lek. Section Abstract Doc Link 8711189 Disease Relevance 0.36 Pain Relevance 0.12
Also, our data do not provide an explanation for the unexpected increase of methemoglobin levels during infusion of a relatively low dose of sodium nitrite in one subject.


Positive_regulation (increase) of Gene_expression (levels) of methemoglobin
6) Confidence 0.46 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018414 Disease Relevance 0.11 Pain Relevance 0.03
Auto-oxidation of hemoglobin, which occurs to a small extent physiologically, leads to the production of methemoglobin and O2- [15,16].
Positive_regulation (leads) of Gene_expression (production) of methemoglobin
7) Confidence 0.03 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 0.74 Pain Relevance 0.04

General Comments

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