INT6306

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Context Info
Confidence 0.64
First Reported 1992
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.48
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1A) signal transducer activity (HTR1A)
Anatomy Link Frequency
artery 2
tail 2
HTR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Antinociceptive 1 99.28 Very High Very High Very High
Sumatriptan 4 99.12 Very High Very High Very High
tail-flick 3 98.64 Very High Very High Very High
agonist 8 96.00 Very High Very High Very High
antagonist 2 93.96 High High
Potency 1 90.24 High High
Migraine 1 80.20 Quite High
Serotonin 1 75.88 Quite High
fluoxetine 1 70.16 Quite High
withdrawal 2 56.28 Quite High
Disease Link Frequency Relevance Heat
Nociception 4 94.40 High High
Increased Venous Pressure Under Development 1 93.00 High High
Headache 1 80.20 Quite High
Hyperalgesia 1 75.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observations suggest that the sumatriptan-induced contraction of the dural artery is mediated via activation of 5-HT1D or 5-HT1-like receptors, whereas it does not appear to activate the 5-HT2 receptors.
Positive_regulation (mediated) of Positive_regulation (activation) of 5-HT1-like in artery associated with sumatriptan
1) Confidence 0.64 Published 1992 Journal Cephalalgia Section Abstract Doc Link 1326402 Disease Relevance 0.17 Pain Relevance 0.51
No differences in magnitude of the effect of the two receptor subtypes were found, indicating that stimulation of either 5-HT1A or 5-HT1B receptors was equipotent in producing the antinociceptive tail-flick response.
Positive_regulation (equipotent) of Positive_regulation (stimulation) of 5-HT1A in tail associated with tail-flick and antinociceptive
2) Confidence 0.49 Published 1992 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1410132 Disease Relevance 0.30 Pain Relevance 0.40
The effect of 5-HT on ERK activation appeared to be mediated through the activation of 5-HT1A receptors since similar results were obtained with R-+-8-hydroxy-DPAT, a selective 5-HT1A receptor agonist and WAY100635, a selective 5-HT1A receptor antagonist, reversed the 5-HT and the R-+-8-hydroxy-DPAT effects.
Positive_regulation (mediated) of Positive_regulation (activation) of 5-HT1A associated with antagonist and agonist
3) Confidence 0.49 Published 2004 Journal Life Sci. Section Abstract Doc Link 15530505 Disease Relevance 0 Pain Relevance 0.24

General Comments

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