INT63067

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 6.93
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYC) chromosome organization (MYC) nucleolus (MYC)
nucleus (MYC) DNA binding (MYC) protein complex (MYC)
Anatomy Link Frequency
HL-60 2
blood 1
B-cell 1
SK-BR-3 1
MCF-7 1
MYC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 94.24 High High
pain flank 1 82.16 Quite High
palliative 2 62.88 Quite High
Pain 7 27.44 Quite Low
vincristine 10 19.60 Low Low
imagery 9 17.00 Low Low
Somatostatin 4 14.92 Low Low
abdominal pain 10 5.00 Very Low Very Low Very Low
member 8 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diffuse Large B-cell Lymphoma 21 99.84 Very High Very High Very High
Cancer 139 99.66 Very High Very High Very High
Disease 91 99.30 Very High Very High Very High
Lymphatic System Cancer 148 99.08 Very High Very High Very High
Glycogen Storage Disease Type Vi 5 98.24 Very High Very High Very High
Malignant Neoplastic Disease 16 95.80 Very High Very High Very High
Carcinoma 7 94.68 High High
INFLAMMATION 9 94.24 High High
Breast Cancer 203 92.24 High High
Apoptosis 23 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DLBCL with c-myc translocation can be difficult to reliably differentiate from BL by currently available diagnostic tools [14].
Localization (translocation) of myc associated with lymphatic system cancer and diffuse large b-cell lymphoma
1) Confidence 0.78 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 1.38 Pain Relevance 0
Gene locus translocations of myc, IgH, and bcl-2 were confirmed by FISH analysis in the second case.
Localization (translocations) of myc
2) Confidence 0.78 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 0.64 Pain Relevance 0
Although the 8q24 translocation was not detected by karyotypic analysis of the peripheral blood mononuclear cells (PBMNC), Southern blot analysis revealed that the c-myc rearrangements had occurred.
Localization (occurred) of c-myc in blood
3) Confidence 0.73 Published 1996 Journal Int. J. Hematol. Section Abstract Doc Link 8713579 Disease Relevance 0.71 Pain Relevance 0.08
Dual translocation of t(8;14) (c-myc) and t(14;18) (bcl-2) was reported to be associated with extremely poor prognosis.
Localization (translocation) of myc
4) Confidence 0.68 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1904237 Disease Relevance 0.44 Pain Relevance 0
Dual translocations of t(8;14) and t(14;18) involving c-myc and bcl-2 have been reported in Burkitt-like lymphoma patients [9-12]. 13 such patients with the dual translocation were found to have rapid clinical course and extremely poor prognosis [9].
Localization (translocations) of myc associated with lymphatic system cancer
5) Confidence 0.68 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 0.81 Pain Relevance 0
In another cell line of BL, a novel gene, bcl7a, from the triple translocation t(8;14;12) was identified [13]. c-myc translocation can also be seen in diffuse large B-cell lymphoma (DLBCL).
Localization (translocation) of myc in B-cell associated with lymphatic system cancer and diffuse large b-cell lymphoma
6) Confidence 0.68 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 1.24 Pain Relevance 0
Our data indicated high-level gains at the c-MYC locus in SK-BR-3 and MCF-7 (+2.84 and +1.19 log2 ratios, respectively) corresponding to previously reported change in copy number [7,37,38].
Localization (locus) of MYC in MCF-7
7) Confidence 0.65 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0 Pain Relevance 0
ER/PR-negative tumors are often associated with aggressive disease, and these tumors frequently show amplification of HER2, c-Myc, and Int2 oncogenes, and mutations of the p53 tumor suppressor gene.
Localization (amplification) of c-Myc associated with cancer and disease
8) Confidence 0.38 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.13 Pain Relevance 0.11
This work was soon supplemented by the generation of human iPSCs by two groups, one of whom [186] showed that adult human dermal fibroblasts can also be reprogrammed by overexpression of OCT4, SOX2, KLF4, and c-MYC, while another [188] made use of a slightly different set of factors (OCT4, SOX2, LIN28, and NANOG) to reprogram both fetal and adult human fibroblasts.
Localization (generation) of c-MYC in fibroblasts
9) Confidence 0.36 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0 Pain Relevance 0
Myc, specifically c-myc is abundant in proliferating HL-60 cells, but its downregulation is associated with differentiating HL-60 cells.
Localization (abundant) of Myc in HL-60
10) Confidence 0.33 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0.14 Pain Relevance 0
Myc, specifically c-myc is abundant in proliferating HL-60 cells, but its downregulation is associated with differentiating HL-60 cells.
Localization (abundant) of myc in HL-60
11) Confidence 0.28 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0.14 Pain Relevance 0
The potential target genes of miR-145 encode oncogenic proteins, such as myc, kras, fos, yes, fli, cyclin D2, and MAPK transduction proteins [31]. miR-145 targets the insulin receptor substrate-1 (IRS-1) and miR-151-3p targets the insulin receptor substrate-4 (IRS-4), which regulated cell communication, receptor and membrane activities.
Localization (kras) of myc
12) Confidence 0.27 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.29 Pain Relevance 0
Our data indicated high-level gains at the c-MYC locus in SK-BR-3 and MCF-7 (+2.84 and +1.19 log2 ratios, respectively) corresponding to previously reported change in copy number [7,37,38].
Localization (locus) of MYC in SK-BR-3
13) Confidence 0.22 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0 Pain Relevance 0

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