INT6307

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Context Info
Confidence 0.67
First Reported 1992
Last Reported 2000
Negated 0
Speculated 1
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 3.11
Pain Relevance 7.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1D) signal transducer activity (HTR1D)
Anatomy Link Frequency
plasma 2
trigeminal ganglia 2
dorsal root ganglia 2
brain 1
dopamine neurons 1
HTR1D (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 21 100.00 Very High Very High Very High
agonist 17 99.60 Very High Very High Very High
Sumatriptan 56 99.32 Very High Very High Very High
Dopamine 7 99.02 Very High Very High Very High
gABA 3 98.58 Very High Very High Very High
cocaine 9 98.06 Very High Very High Very High
Migraine 9 94.52 High High
monoamine 2 90.56 High High
Potency 6 89.72 High High
drug abuse 1 87.48 High High
Disease Link Frequency Relevance Heat
Glioma 10 100.00 Very High Very High Very High
Small Cell Lung Cancer 3 99.32 Very High Very High Very High
Lung Cancer 1 99.20 Very High Very High Very High
Autism 7 97.96 Very High Very High Very High
Congenital Anomalies 2 96.24 Very High Very High Very High
Headache 9 94.52 High High
Disease 1 93.00 High High
Increased Venous Pressure Under Development 1 92.48 High High
Genetic Predisposition To Disease 1 92.28 High High
Stress 3 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sumatriptan-induced elevation of [Ca2+]i via activation of the 5-HT1D subtypes may provide a molecular mechanism of action by which sumatriptan could directly constrict cerebral blood vessels and alleviate migraine symptoms.
Positive_regulation (activation) of 5-HT1D in blood vessels associated with sumatriptan and migraine
1) Confidence 0.67 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8396718 Disease Relevance 0.17 Pain Relevance 0.45
The neuroendocrine effects of sumatriptan differ from those of previously described 5-HT-receptor agonists, and may be a consequence of selective activation of 5-HT1D or 5-HT1B receptors.
Positive_regulation (activation) of 5-HT1D associated with sumatriptan and agonist
2) Confidence 0.67 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7862876 Disease Relevance 0.09 Pain Relevance 0.43
It is concluded that CP-122,288 exhibits a prejunctional selectivity in the meninges to inhibit dural plasma protein extravasation independent of 5-HT1D alpha and 5-HT1D beta receptor activation.
Positive_regulation (activation) of 5-HT1D in plasma
3) Confidence 0.67 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7601213 Disease Relevance 0 Pain Relevance 0.51
It is concluded that CP-122,288 exhibits a prejunctional selectivity in the meninges to inhibit dural plasma protein extravasation independent of 5-HT1D alpha and 5-HT1D beta receptor activation.
Positive_regulation (activation) of 5-HT1D in plasma
4) Confidence 0.67 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7601213 Disease Relevance 0 Pain Relevance 0.51
In conclusion, evidence is provided that both recombinant h 5-HT1B and h 5-HT1D receptors stably transfected in C6 glioma cells are positively coupled to Ca2+-dependent K+ channels, and the outward hyperpolarizing current mediated by these channels is dependent upon IP3 receptor-mediated intracellular Ca2+ release.
Positive_regulation (coupled) of 5-HT1D associated with glioma
5) Confidence 0.49 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9879718 Disease Relevance 0.17 Pain Relevance 0.28
Activation of recombinant h 5-HT1B and h 5-HT1D receptors stably expressed in C6 glioma cells produces increases in Ca2+-dependent K+ current.
Positive_regulation (Activation) of 5-HT1D associated with glioma
6) Confidence 0.49 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 9879718 Disease Relevance 0.35 Pain Relevance 0.22
The presence of 5-HT1D alpha, 5-HT1D beta, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT7 receptor subtype messenger RNA was detected in dorsal root ganglia from three of the four subjects. 5-HT1A receptor subtype messenger RNA was detected in one of the four subjects.
Positive_regulation (presence) of 5-HT1D in dorsal root ganglia
7) Confidence 0.49 Published 1997 Journal Neuroscience Section Abstract Doc Link 9316030 Disease Relevance 0.22 Pain Relevance 0.49
The presence of 5-HT1D alpha, 5-HT1D beta, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT7 receptor subtype messenger RNA was detected in dorsal root ganglia from three of the four subjects. 5-HT1A receptor subtype messenger RNA was detected in one of the four subjects.
Positive_regulation (presence) of 5-HT1D in dorsal root ganglia
8) Confidence 0.49 Published 1997 Journal Neuroscience Section Abstract Doc Link 9316030 Disease Relevance 0.22 Pain Relevance 0.49
Messages for the 5-HT1D alpha and 5-HT1D beta receptors were expressed in all except one of the 10 trigeminal ganglia studied.
Positive_regulation (Messages) of 5-HT1D in trigeminal ganglia
9) Confidence 0.49 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8700126 Disease Relevance 0.08 Pain Relevance 0.33
Messages for the 5-HT1D alpha and 5-HT1D beta receptors were expressed in all except one of the 10 trigeminal ganglia studied.
Positive_regulation (Messages) of 5-HT1D in trigeminal ganglia
10) Confidence 0.49 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8700126 Disease Relevance 0.08 Pain Relevance 0.33
To assess sensitivity of the 5-HT1d receptor, growth hormone response to the 5-HT1d receptor agonist sumatriptan was studied in adult autistic patients and matched normal controls.
Positive_regulation (response) of 5-HT1d associated with sumatriptan, autism and agonist
11) Confidence 0.49 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 10808042 Disease Relevance 0.51 Pain Relevance 0.36
The data are compatible with a classification of the human 5-HT autoreceptor as being of the 5-HT1D subtype.
Positive_regulation (being) of 5-HT1D
12) Confidence 0.49 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8382263 Disease Relevance 0 Pain Relevance 0.33
Competition experiments using 5-carboxamidotryptamine (5-CT), 3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one (CP 93129) and sumatriptan revealed monophasic displacement curves in various brain regions, suggesting that a homogeneous population of 5-HT1D binding sites was labelled.
Positive_regulation (population) of 5-HT1D in brain associated with sumatriptan
13) Confidence 0.49 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8164519 Disease Relevance 0.07 Pain Relevance 0.30
We conclude that cocaine acts to modulate the GABA input to A10 dopamine neurons via inhibition of the 5-HT transporter, increasing the concentration of 5-HT at presynaptic 5-HT1D receptors.
Positive_regulation (increasing) of 5-HT1D in dopamine neurons associated with dopamine, gaba and cocaine
14) Confidence 0.49 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7965077 Disease Relevance 0 Pain Relevance 1.27
Genomic samples from 46 unrelated healthy subjects were investigated by single-strand conformation analysis (SSCA) to screen for genetic variation in the human serotonin 1D beta (5-HT1D beta) receptor gene.
Spec (investigated) Positive_regulation (variation) of 5-HT1D associated with serotonin
15) Confidence 0.49 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 7802650 Disease Relevance 0.53 Pain Relevance 0.31
Structural modifications of N- and C-linked (principally hydantoin) analogues at the 5-position were synthesized and their pharmacological activities were utilized to deduce significant steric and electrostatic requirements of the 5-HT1D and 5-HT2A receptor subtypes.
Positive_regulation (requirements) of 5-HT1D
16) Confidence 0.49 Published 1995 Journal J. Med. Chem. Section Abstract Doc Link 7658443 Disease Relevance 0.07 Pain Relevance 0.12
We have recently shown that the mitogenic effect of serotonin (5-hydroxytryptamine, 5-HT) on human small lung carcinoma (SCLC) cells is at least partly due to stimulation of a 5-HT1D receptor type.
Positive_regulation (stimulation) of 5-HT1D in lung associated with lung cancer, small cell lung cancer and serotonin
17) Confidence 0.45 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8566173 Disease Relevance 0.36 Pain Relevance 0.30
The observations suggest that the sumatriptan-induced contraction of the dural artery is mediated via activation of 5-HT1D or 5-HT1-like receptors, whereas it does not appear to activate the 5-HT2 receptors.
Positive_regulation (activation) of 5-HT1D in artery associated with sumatriptan
18) Confidence 0.37 Published 1992 Journal Cephalalgia Section Abstract Doc Link 1326402 Disease Relevance 0.17 Pain Relevance 0.50

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