INT63081

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 1.08
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Itpr3) endoplasmic reticulum (Itpr3) nucleolus (Itpr3)
nucleus (Itpr3) transmembrane transport (Itpr3) cytoplasm (Itpr3)
Anatomy Link Frequency
cardiomyocyte 1
muscle cells 1
spine 1
lumen 1
acinar cells 1
Itpr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 62 99.80 Very High Very High Very High
Action potential 26 99.24 Very High Very High Very High
sodium channel 5 95.44 Very High Very High Very High
Sciatic nerve 3 94.96 High High
Glutamate 80 94.04 High High
gABA 2 94.04 High High
antagonist 54 92.36 High High
Glutamate receptor 5 86.40 High High
Nav1.6 1 83.12 Quite High
nMDA receptor 21 81.64 Quite High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 3 98.18 Very High Very High Very High
Heart Rate Under Development 5 86.24 High High
Bordatella Infection 8 84.88 Quite High
Increased Venous Pressure Under Development 29 74.96 Quite High
Nociception 21 74.64 Quite High
Dysmenorrhea 1 74.56 Quite High
Death 4 63.20 Quite High
Autoimmune Disease 9 50.00 Quite Low
Alcoholic Pancreatitis 4 50.00 Quite Low
Disease 15 40.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IP3R3 is primarily localized at very high levels in nonmyelinating Schwann cells.
Localization (localized) of IP3R3 in Schwann cells
1) Confidence 0.67 Published 2007 Journal Neuroreport Section Abstract Doc Link 17496801 Disease Relevance 0 Pain Relevance 0.28
Sodium-dependent action potentials induced by brevetoxin-3 trigger both IP3 increase and intracellular Ca2+ release in rat skeletal myotubes.
Localization (release) of IP3 in myotubes associated with action potential
2) Confidence 0.30 Published 2008 Journal Cell Calcium Section Title Doc Link 18276006 Disease Relevance 0 Pain Relevance 0.24
Therefore, the involvements of PLC, IP3 receptor and PKC were tested.
Localization (receptor) of IP3 associated with kinase c
3) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0 Pain Relevance 0.23
In the postsynaptic dendritic spine, the activation of both mGluR1 and mGluR5 elevates intracellular Ca2+ concentration that is due to the IP3-mediated intracellular Ca2+ release [40], which may lead to the activation of the Ca2+-sensitive enzyme NOS [22] and CaMKII, via the binding with Ca2+-bound protein calmodulin, and then the positive modulation of AMPA receptor channels.
Localization (release) of IP3 in spine
4) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0 Pain Relevance 0.26
Group I mGluRs (mGluR1 and 5) activate phospholipase C (PLC) via Gq-protein, resulting in phosphoinositide hydrolysis, Ca2+ release from inositol 1,4,5-triphosphate (IP3)-sensitive intracellular stores, and protein kinase C (PKC) activation by diacylglycerol (DAG) [12].
Localization (release) of IP3 associated with kinase c
5) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0.25 Pain Relevance 0.55
activation and Ca2+ release through IP3 receptor/channels [43].
Localization (release) of IP3
6) Confidence 0.09 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.03
It was suggested that mitochondria could increase the release of Ca2+ from IP3R channels by rapidly removing Ca2+ from their mouth, so decreasing Ca2+-induced inactivation of the channels.
Localization (release) of IP3R in mouth
7) Confidence 0.08 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.03
Pre-treatment of AR4-2J cells with selective inhibitors of known mediators of stimulus-secretion coupling in pancreatic acinar cells has shown that beer-induced amylase secretion is mediated by activation of phospholipase C (PLC), binding of IP3 to its receptor (IP3-R) and subsequent calcium release from intracellular stores.
Localization (release) of IP3-R in acinar cells
8) Confidence 0.07 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872306 Disease Relevance 0 Pain Relevance 0
Thereby it was suggested that NAADP, which peaks within seconds after T cell receptor activation, acts as the initializing trigger supporting later Ca2+ release events by amplifying IP3- and cyclic ADP-ribose-induced Ca2+ release (Gasser et al., 2006).
Localization (release) of IP3 in T cell
9) Confidence 0.04 Published 2010 Journal Brain Section Body Doc Link PMC2892943 Disease Relevance 0.06 Pain Relevance 0.03
With ligand bound to the IP3 receptor, Ca2+ stored within the ER lumen is released into the cytosol (see [19]).
Localization (released) of IP3 receptor in lumen
10) Confidence 0.03 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2225403 Disease Relevance 0 Pain Relevance 0.25
G alpha(q) stimulates phospholipase C resulting in the formation of two second messengers: inositol 1,4,5-trisphosphate (InsP3) which releases Ca2+ from the sarcoplasmic reticulum, and 1,2-diacylglycerol which activates protein kinase C.
Localization (releases) of InsP3 in reticulum associated with kinase c
11) Confidence 0.02 Published 1995 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 8713997 Disease Relevance 0.24 Pain Relevance 0.12
Vasopressin promotes cardiac hypertrophy in neonatal rat hearts via direct effects on cardiomyocyte protein synthesis secondary to IP3-mediated intracellular calcium release [79].
Localization (release) of IP3 in cardiomyocyte associated with coronary heart disease
12) Confidence 0.02 Published 2004 Journal Crit Care Section Body Doc Link PMC420051 Disease Relevance 0.52 Pain Relevance 0
Due to the similarity between lindane and inositol 1, 4, 5 triphosphate (IP3) [5], it has been suggested that lindane releases Ca2+ from IP3-sensitive intracellular stores in macrophages [6] and smooth myometrial muscle cells [7].
Localization (releases) of IP3 in muscle cells
13) Confidence 0.02 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC117783 Disease Relevance 0 Pain Relevance 0.09

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