INT63106

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.17
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
plasma 1
spinal cord 1
hippocampus 1


Pain Term Frequency Confidence Heat
Spinal cord 8 99.68 Very High Very High Very High
amygdala 13 99.60 Very High Very High Very High
Hippocampus 3 99.32 Very High Very High Very High
Morphine 10 99.08 Very High Very High Very High
tolerance 2 95.68 Very High Very High Very High
spinal dorsal horn 2 88.24 High High
Dopamine 28 29.20 Quite Low
Pain 2 25.00 Low Low
Nucleus accumbens 14 17.60 Low Low
Cholecystokinin 3 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Disease 1 82.76 Quite High
Ulcers 1 82.44 Quite High
Duodenal Ulcer 2 50.00 Quite Low
Cognitive Disorder 6 38.64 Quite Low
Urological Neuroanatomy 1 36.88 Quite Low
Dislocations 1 5.00 Very Low Very Low Very Low
Schizophrenia 9 5.00 Very Low Very Low Very Low
Alcohol Intoxication 1 5.00 Very Low Very Low Very Low
Cold Sores 1 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that NO is involved in the increase of formalin-induced Fos-LI in the spinal cord of morphine-tolerant rats and may play an important role in the development of morphine tolerance.
Positive_regulation (increase) of LI in spinal cord associated with tolerance, morphine and spinal cord
1) Confidence 0.67 Published 2000 Journal Sheng Li Xue Bao Section Abstract Doc Link 11956571 Disease Relevance 0 Pain Relevance 1.26
RESULTS: In duodenal ulcer patients (n = 9), patients with HSV (n = 9), patients with truncal vagotomy (n = 9) and control subjects (n = 9), infusion of stepwise increasing doses of cerulein (1-16 ng.kg-1.h-1) induced dose related changes in plasma CCK-LI.
Positive_regulation (induced) of LI in plasma
2) Confidence 0.49 Published 1996 Journal Hepatogastroenterology Section Body Doc Link 8714233 Disease Relevance 0.17 Pain Relevance 0
Taken together, the results from various lesion studies suggest that the involvement of particular brain structures (hippocampus, PL, OFC, BLA) in preventing the emergence of LI is specific to certain experimental conditions.


Positive_regulation (emergence) of LI in hippocampus associated with hippocampus and amygdala
3) Confidence 0.49 Published 2010 Journal Neuroscience Section Body Doc Link PMC2930211 Disease Relevance 0 Pain Relevance 0.20

General Comments

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