INT63109

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.04
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
liver 1
monocytes 1
heart 1
Chol1 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 2 89.00 High High
diclofenac 5 77.36 Quite High
cINOD 50 76.52 Quite High
COX-2 inhibitor 65 70.44 Quite High
alcohol 13 65.84 Quite High
agonist 2 61.20 Quite High
ketamine 1 29.12 Quite Low
Analgesic 5 21.40 Low Low
Inflammation 64 20.84 Low Low
Kinase C 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 76 99.98 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 99.92 Very High Very High Very High
Coronary Artery Disease 49 99.40 Very High Very High Very High
Cardiovascular Disease 66 96.00 Very High Very High Very High
Atherosclerosis 53 92.04 High High
Cv General 3 Under Development 2 89.00 High High
Myocardial Infarction 52 88.08 High High
Obesity 22 83.80 Quite High
Diabetes Mellitus 162 79.92 Quite High
Disease 205 77.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
T+294C SNP is associated with elevated plasma LDL cholesterol and apoB levels in men and we show in this work that similar associations are operating in women, we also looked for a potential gene-to-gene interaction between PPAR?
Gene_expression (levels) of cholesterol in plasma
1) Confidence 0.75 Published 2006 Journal International Journal of Medical Sciences Section Body Doc Link PMC1525216 Disease Relevance 0.63 Pain Relevance 0.03
The non-selective COX inhibitor indomethacin also produced a significant reduction in cholesterol 27-hydroxylase and ABCA1 mRNA expression (50 ?
Gene_expression (expression) of cholesterol
2) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.06
Exposure to NS398 markedly reduced cholesterol 27-hydroxylase message expression by THP-1 monocytes (50 ?
Gene_expression (expression) of cholesterol in monocytes
3) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0
and immune complex-C1q complexes, diminish expression of both cholesterol 27-hydroxylase, an anti-atherogenic enzyme, and ATP-binding cassette transporter A1 (ABCA1), a protein that controls a cellular pathway for secretion of cholesterol for transport to the liver, in cells relevant to atherogenesis [10,11].
Gene_expression (expression) of cholesterol in liver associated with atherosclerosis
4) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.45 Pain Relevance 0.23
The latter is a key intermediate in cholesterol synthesis and aids in decreasing LDL cholesterol and increasing HDL cholesterol levels [239, 240].
Gene_expression (levels) of cholesterol associated with acquired immune deficiency syndrome or hiv infection and disorder of lipid metabolism
5) Confidence 0.65 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.49 Pain Relevance 0
The latter is a key intermediate in cholesterol synthesis and aids in decreasing LDL cholesterol and increasing HDL cholesterol levels [239, 240].
Gene_expression (decreasing) of cholesterol associated with acquired immune deficiency syndrome or hiv infection and disorder of lipid metabolism
6) Confidence 0.65 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.50 Pain Relevance 0
LDL-Cholesterol = Serum Total cholesterol - (HDL- Cholesterol 1 VLDL-Cholesterol)

Statistical analysis

Gene_expression (analysis) of Cholesterol associated with disorder of lipid metabolism
7) Confidence 0.65 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2881655 Disease Relevance 0.56 Pain Relevance 0.03
Our data demonstrate that pharmacological inhibition of COX reduces expression of the cholesterol-metabolizing enzyme cholesterol 27-hydroxylase and the cholesterol transport protein ABCA1.
Gene_expression (expression) of cholesterol
8) Confidence 0.58 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.37 Pain Relevance 0.17
ACAT: acyl CoA cholesteryl acyl transferase; AT: atorvastatin; CETP: cholesterol ester transfer protein; CHD: coronary heart disease; CYP7: cholesterol 7?
Gene_expression (transfer) of cholesterol in heart associated with coronary artery disease
9) Confidence 0.58 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1262701 Disease Relevance 0.50 Pain Relevance 0
Our data demonstrate that pharmacological inhibition of COX reduces expression of the cholesterol-metabolizing enzyme cholesterol 27-hydroxylase and the cholesterol transport protein ABCA1.
Gene_expression (expression) of cholesterol
10) Confidence 0.58 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.37 Pain Relevance 0.17
At each visit, research assistants recorded the patient's BP as assessed by the nursing assistant or nurse, and the value and date of the most recent hemoglobin A1c and low density lipoprotein cholesterol (LDL-c) levels as recorded in the medical record.
Gene_expression (levels) of cholesterol
11) Confidence 0.07 Published 2010 Journal Implement Sci Section Body Doc Link PMC2914084 Disease Relevance 0.40 Pain Relevance 0
The levels of total triglycerides, cholesterol, LDL-C and VLDL-C were significantly raised in both groups of patients.
Gene_expression (raised) of cholesterol
12) Confidence 0.05 Published 1995 Journal J Pak Med Assoc Section Abstract Doc Link 8714621 Disease Relevance 0.78 Pain Relevance 0.09

General Comments

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