INT63112

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Context Info
Confidence 0.17
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 3.83
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Hrh1) plasma membrane (Hrh1) nucleus (Hrh1)
cytoplasm (Hrh1) signal transducer activity (Hrh1)
Anatomy Link Frequency
neurons 1
brain 1
body 1
Hrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 31 100.00 Very High Very High Very High
depression 52 99.60 Very High Very High Very High
tetrodotoxin 3 99.16 Very High Very High Very High
Neurotransmitter 8 96.84 Very High Very High Very High
Serotonin 36 94.72 High High
Lamotrigine 69 94.36 High High
antagonist 21 94.24 High High
agonist 7 93.64 High High
fluoxetine 11 89.20 High High
antidepressant 13 83.52 Quite High
Disease Link Frequency Relevance Heat
Depression 81 99.60 Very High Very High Very High
Body Weight 1 98.64 Very High Very High Very High
Weight Gain 9 94.76 High High
Manic Depressive Disorder 390 93.04 High High
Overactive Bladder 34 92.92 High High
Stress Incontinence 51 92.40 High High
Anxiety Disorder 102 84.12 Quite High
Pressure Volume 2 Under Development 4 79.60 Quite High
Cognitive Disorder 7 77.72 Quite High
Psychosis 22 75.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-hydroxylase (DBH), glucocorticoid receptor (NR3C1), histamine H1 receptor (HRH1) and melanocortin 2 receptor (MCR2) genes were associated with the treatment response.
histamine H1 receptor Binding (associated) of
1) Confidence 0.17 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.43 Pain Relevance 0.44
Aiming to evaluate common genetic variation for association with clinical improvement in BDI depression following treatment with OFC, Perlis et al. [200] analyzed a cohort of 88 patients treated with OFC, showing significant association for dopamine D3 receptor (DRD3) and HRH1 genes and response to OFC.
HRH1 Spec (analyzed) Binding (association) of associated with dopamine and depression
2) Confidence 0.17 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.53 Pain Relevance 0.21
-hydroxylase (DBH), glucocorticoid receptor (NR3C1), histamine H1 receptor (HRH1) and melanocortin 2 receptor (MCR2) genes were associated with the treatment response.
HRH1 Binding (associated) of
3) Confidence 0.17 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.38 Pain Relevance 0.44
We conclude that HA directly depolarizes cholinergic MS/DBB neurons by acting as an H1 receptor, which primarily couples to an increase in a TTX-insensitive Na+ conductance.
H1 receptor Binding (couples) of in neurons associated with tetrodotoxin
4) Confidence 0.16 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8714646 Disease Relevance 0 Pain Relevance 0.48
In human brain tissue, olanzapine displays very high affinity for the H1 histamine receptor, high affinity for 5-HT2A and 5-HT2C receptors [12].
H1 histamine receptor Binding (affinity) of in brain
5) Confidence 0.07 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC57001 Disease Relevance 1.25 Pain Relevance 0.11
Patients with depression show a decrease in H1 receptor binding, and this decrease is correlated with illness severity.34 Therefore, the modulation of histaminergic activity by quetiapine to induce sleep may be related to the reduction of depressive symptoms in these patients.
H1 receptor Binding (binding) of associated with depression
6) Confidence 0.03 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938299 Disease Relevance 0.69 Pain Relevance 0.21
Iloperidone also displayed low affinity for the histamine H1 receptors23 and has in fact little effect on body weight (see below), although some other neurotransmitter may be involved in the less severe weight gain potential than with other antipsychotics.26
histamine H1 receptors23 Binding (affinity) of in body associated with neurotransmitter, body weight and weight gain
7) Confidence 0.02 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2846148 Disease Relevance 0.43 Pain Relevance 0.43
For example, Sanchez et al (2003) reported that citalopram and R-citalopram have affinity for the histamine 1 receptor, whereas escitalopram does not.
histamine 1 receptor Binding (affinity) of
8) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655080 Disease Relevance 0.12 Pain Relevance 0.45

General Comments

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