INT63113

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 30
Total Number 32
Disease Relevance 22.85
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HRAS) signal transduction (HRAS) Golgi apparatus (HRAS)
plasma membrane (HRAS) nucleus (HRAS) GTPase activity (HRAS)
Anatomy Link Frequency
Caco-2 2
ovary 2
epithelial cells 1
ducts 1
eye 1
HRAS (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 324 99.42 Very High Very High Very High
COX2 2 98.84 Very High Very High Very High
fibrosis 64 98.36 Very High Very High Very High
Potency 34 97.88 Very High Very High Very High
cINOD 9 95.40 Very High Very High Very High
Osteoarthritis 28 94.84 High High
tetrodotoxin 3 93.16 High High
Chronic pancreatitis 27 89.60 High High
antagonist 6 85.00 Quite High
agonist 3 84.40 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 76 100.00 Very High Very High Very High
Adhesions 108 99.98 Very High Very High Very High
Osteoporosis 70 99.80 Very High Very High Very High
Metastasis 54 99.56 Very High Very High Very High
Cancer 253 99.50 Very High Very High Very High
Endometriosis 414 99.42 Very High Very High Very High
Apoptosis 52 99.42 Very High Very High Very High
Adenocarcinoma 58 99.24 Very High Very High Very High
Cirrhosis 67 98.92 Very High Very High Very High
Breast Cancer 28 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pancreatic cancer has a highly complex molecular pathology and is uniquely characterized by a high frequency of activating K-ras mutations and loss of function of the p53, p16, and Smad 4 tumor suppresser genes (Bardeesy & DePinho 2002).
Positive_regulation (activating) of K-ras associated with cancer and pancreatic cancer
1) Confidence 0.67 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012429 Disease Relevance 1.15 Pain Relevance 0
Pancreatic ductal adenocarcinoma (PDA), one of the deadliest human cancers, often involves somatic activation of K-Ras oncogenes.
Positive_regulation (activation) of K-Ras associated with adenocarcinoma and cancer
2) Confidence 0.67 Published 2007 Journal Cancer Cell Section Abstract Doc Link 17349585 Disease Relevance 0.80 Pain Relevance 0.14
Among these, the activation of the K-ras oncogene and inactivation of the p53 tumor suppressor gene have been proposed to play a pivotal role in PDAC progression [26,27].
Positive_regulation (activation) of K-ras associated with adenocarcinoma and cancer
3) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 1.15 Pain Relevance 0
A 24-h treatment with DFMO caused a dose-dependent decrease in the colony-forming ability of cells expressing an activated K-ras but had no effect on the viability of the parental Caco-2 cells.
Positive_regulation (activated) of K-ras in Caco-2
4) Confidence 0.67 Published 2000 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 11097222 Disease Relevance 0.64 Pain Relevance 0.05
Influence of K-ras activation on the survival responses of Caco-2 cells to the chemopreventive agents sulindac and difluoromethylornithine.
Positive_regulation (activation) of K-ras in Caco-2
5) Confidence 0.67 Published 2000 Journal Cancer Epidemiol. Biomarkers Prev. Section Title Doc Link 11097222 Disease Relevance 0.55 Pain Relevance 0.10
The findings suggest that K-ras activation is frequently associated with both IPMT and ductal cell carcinoma.
Positive_regulation (activation) of K-ras associated with cancer and carcinoma
6) Confidence 0.67 Published 1999 Journal Hum. Pathol. Section Abstract Doc Link 10374765 Disease Relevance 1.29 Pain Relevance 0.23
Indeed, it was recently shown that activation of K-Ras or inactivation of Pten in mouse ovarian surface epithelial cells can lead to endometriosis-like lesions in the ovary [46].
Positive_regulation (activation) of K-Ras in ovary associated with endometriosis
7) Confidence 0.67 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.81 Pain Relevance 0.21
Since activating K-ras mutations are described in more than 80% of pancreatic cancers and are known to increase intracellular levels of p21WAF1/CIP1 in experimental models, the possible role of activating K-ras mutations in an induction of the p21WAF1/CIP1 expression was investigated in our study.
Positive_regulation (increase) of K-ras associated with pancreatic cancer
8) Confidence 0.49 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.58 Pain Relevance 0.16
Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multistep carcinogenesis.
Positive_regulation (evaluation) of K-ras in pancreas associated with hyperplasia
9) Confidence 0.49 Published 1999 Journal Hum. Pathol. Section Title Doc Link 10029438 Disease Relevance 0.76 Pain Relevance 0.07
Exposure to mono-ortho PCBs 28 and 118 increased risk in similar magnitude for both mutated and wild-type K-ras.
Positive_regulation (increased) of K-ras
10) Confidence 0.49 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247607 Disease Relevance 0.68 Pain Relevance 0
BACKGROUND: Human pancreatic cancers exhibit a high frequency of K-ras mutations.
Positive_regulation (frequency) of K-ras associated with pancreatic cancer
11) Confidence 0.49 Published 1997 Journal Am. J. Surg. Section Abstract Doc Link 9324130 Disease Relevance 0.17 Pain Relevance 0.07
Furthermore, expression of epidermal growth factor receptor (EGFR) and its ligands; serine protease inhibitor Kazal type 3 (Spink3) and transforming growth factor alpha (TGF alpha) and activation of K-Ras (GTP-Ras formation), which are frequently observed in human PDA, were indeed observed in parallel with TCs formation.
Positive_regulation (activation) of K-Ras associated with adenocarcinoma
12) Confidence 0.49 Published 2010 Journal Exp. Anim. Section Abstract Doc Link 20660988 Disease Relevance 0.88 Pain Relevance 0.43
As overexpression of AXL and SHC1 theoretically activates both PI3K-Akt and MAPK pathways, dysregulation of these genes in human endometriosis may correspond to oncogenic activation of K-ras or biallelic losses of Pten in the mouse model of the disease.
Positive_regulation (activation) of K-ras associated with endometriosis and disease
13) Confidence 0.45 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.06 Pain Relevance 0.35
ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells.
Positive_regulation (upregulation) of H-ras in epithelial cells associated with cox2 and apoptosis
14) Confidence 0.45 Published 2005 Journal FEBS Lett. Section Title Doc Link 16253239 Disease Relevance 0.58 Pain Relevance 0.23
Since activating K-ras mutations are described in more than 80% of pancreatic cancers and are known to increase intracellular levels of p21WAF1/CIP1 in experimental models, the possible role of activating K-ras mutations in an induction of the p21WAF1/CIP1 expression was investigated in our study.
Spec (possible) Positive_regulation (activating) of K-ras associated with pancreatic cancer
15) Confidence 0.45 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.59 Pain Relevance 0.16
The possible role of activating K-ras mutations in an induction of p21WAF1/CIP1 expression was not confirmed in this study.
Spec (possible) Positive_regulation (activating) of K-ras
16) Confidence 0.45 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 0.90 Pain Relevance 0.22
Overall, HER-2/neu was positive in normal ducts, ductal hyperplasia, dysplasia, and carcinoma cells in 0 of 30, 11 of 20 (55%), 10 of 15 (67%), and 12 of 15 (80%), respectively, with progressive increase in the intensity of staining; p53 was positive in 1 of 30 (3%), 0 of 20, 3 of 15 (20%), and 13 of 15 (80%), respectively, and K-ras was positive in 1 of 30 (3%), 6 of 20 (30%), 11 of 15 (73%), and 8 of 15% (53%), respectively.
Positive_regulation (positive) of K-ras in ducts associated with cleidocranial dysplasia, carcinoma and hyperplasia
17) Confidence 0.45 Published 1999 Journal Hum. Pathol. Section Abstract Doc Link 10029438 Disease Relevance 0.89 Pain Relevance 0.09
As discussed above, either oncogenic activation of K-ras or biallelic losses of Pten of ovarian surface epithelium causes endometriosis-like-lesions in the mouse ovary [46].
Positive_regulation (activation) of K-ras in ovary associated with endometriosis
18) Confidence 0.45 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.06 Pain Relevance 0.39
Hydroxyapatite (HA) has previously been used as a coating on total hip prostheses because it is capable of inducing new bone growth over a gap and enhances stability of an implant (Söballe et al. 1993).
Positive_regulation (enhances) of HA in hip
19) Confidence 0.28 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2917575 Disease Relevance 0 Pain Relevance 0
It has been suggested that the NF1 mutations produce abnormal neurofibromin, leading to increased levels of activating proteins (e.g., p21ras and p13) [29], which contribute to the cellular proliferation of Schwann cells associated with neurofibromas.
Positive_regulation (increased) of p21ras in Schwann cells associated with neurofibroma and hyperplasia
20) Confidence 0.13 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2954971 Disease Relevance 1.54 Pain Relevance 0

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