INT63121

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2010
Negated 4
Speculated 3
Reported most in Body
Documents 29
Total Number 32
Disease Relevance 23.02
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
monocyte 2
APC 2
plasma 1
liver 1
colon 1
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 215 99.80 Very High Very High Very High
Central nervous system 11 99.52 Very High Very High Very High
antagonist 60 98.68 Very High Very High Very High
Opioid 6 98.48 Very High Very High Very High
addiction 6 98.20 Very High Very High Very High
cytokine 83 97.44 Very High Very High Very High
Multiple sclerosis 54 97.24 Very High Very High Very High
agonist 92 97.12 Very High Very High Very High
Anterior cingulate cortex 6 93.72 High High
cva 15 91.16 High High
Disease Link Frequency Relevance Heat
Cancer 508 100.00 Very High Very High Very High
Familial Adenomatous Polyposis 221 100.00 Very High Very High Very High
Hemorrhage 62 99.98 Very High Very High Very High
INFLAMMATION 242 99.80 Very High Very High Very High
Pancreatitis 357 99.62 Very High Very High Very High
Endotoxemia 10 99.28 Very High Very High Very High
Sepsis 269 99.12 Very High Very High Very High
Opiate Addiction 3 98.48 Very High Very High Very High
Skin Cancer 10 98.16 Very High Very High Very High
Acute Necrotizing Pancreatitis 28 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A prospective evaluation of long-term health outcomes and resource use associated with APC would provide useful information and either support or challenge existing assumptions.
APC Binding (associated) of
1) Confidence 0.41 Published 2007 Journal Crit Care Section Body Doc Link PMC2246225 Disease Relevance 0.20 Pain Relevance 0.04
The remaining human studies finding associations between APC and inflammatory phenomena have involved only hyperacute proinflammatory/procoagulant situations such as reperfusion after cardiopulmonary bypass [34], liver transplantation [26], and renal transplantation [27].
APC Binding (associations) of in liver associated with inflammation
2) Confidence 0.39 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.91 Pain Relevance 0.27
The truncated or functionally inactive APC protein which can result from (1) transcriptional silencing through promoter methylation, (2) a point mutation of the APC gene or (3) loss of heterozygosity (LOH) (Hiltunen et al. 1997; Chen et al. 2005) loses the ability to interact with ?
APC gene Binding (mutation) of associated with familial adenomatous polyposis
3) Confidence 0.37 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.38 Pain Relevance 0
We hypothesized that APC would be associated with decrease in SOFA during the treatment and also aimed to assess organ-failure free days to detect potential signs of benefit of APC in SAP for further hypothesis generating purposes.
APC Binding (associated) of associated with pancreatitis
4) Confidence 0.35 Published 2010 Journal Crit Care Section Body Doc Link PMC2945119 Disease Relevance 1.63 Pain Relevance 0.08
In severe AP, levels of PC and APC were moderately associated with monocyte activation status.
APC Binding (associated) of in monocyte associated with pancreatitis
5) Confidence 0.35 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.16 Pain Relevance 0.28
The upper limit for APC formation may be estimated from APC determinations in various clinical settings where coagulation is known to be activated.
APC Binding (formation) of in upper
6) Confidence 0.35 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.35 Pain Relevance 0
In our study we found no severe bleeding associated with APC treatment.
APC Neg (no) Binding (associated) of associated with hemorrhage
7) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2945119 Disease Relevance 0.83 Pain Relevance 0
This suggestion, however, does not exclude the possibility that significant PC deficiency could also be rate limiting for APC formation in patients with severe AP, as seems to be the case in septic children [17].
APC Binding (formation) of associated with pancreatitis
8) Confidence 0.33 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.89 Pain Relevance 0
We excluded from the standard care group those patients who did not receive APC because of central nervous system bleeding risks (history of severe head trauma that required hospitalization, intracranial surgery, stroke within the previous 3 months, or any history of intracerebral arteriovenous malformation, cerebral aneurysm, or central nervous system mass lesion), because these patients probably have or will have a poor HRQoL related to their underlying illness.
APC Neg (not) Spec (probably) Binding (receive) of in central nervous system associated with brain hemorrhage, cerebral aneurysm, stroke, head trauma, hemorrhage and central nervous system
9) Confidence 0.32 Published 2007 Journal Crit Care Section Body Doc Link PMC2246225 Disease Relevance 0.95 Pain Relevance 0.09
The mutated form of APC cannot bind to ?
APC Neg (cannot) Binding (bind) of associated with familial adenomatous polyposis
10) Confidence 0.32 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.84 Pain Relevance 0
They concluded that the septic patients varied markedly in their ability to generate APC in response to the physiological thrombin stimulus, and attributed the phenomenon to endothelial dysfunction [28].
APC Binding (generate) of
11) Confidence 0.30 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.18 Pain Relevance 0
Furthermore, high affinity [3H]forskolin binding experiments demonstrated that depalmitoylated Gs alpha is able to associated directly with AC during the state of opioid dependence even without preceding receptor activation.
Gs alpha Binding (associated) of associated with addiction and opioid
12) Confidence 0.30 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9415709 Disease Relevance 0.17 Pain Relevance 0.59
Inadequate binding of aPC to EPCR could explain the absence of the anti-inflammatory effect and be responsible for the persistence of monocyte TF expression.
aPC Binding (binding) of in monocyte associated with inflammation
13) Confidence 0.29 Published 2006 Journal Crit Care Section Body Doc Link PMC1550919 Disease Relevance 0.57 Pain Relevance 0.22
When aPC binds to EPCR, it activates a signaling pathway leading to inhibition of NF-?
aPC Binding (binds) of
14) Confidence 0.28 Published 2006 Journal Crit Care Section Body Doc Link PMC1550919 Disease Relevance 0.48 Pain Relevance 0.21
The wild type (non-mutated) APC protein product binds to ?
APC Binding (binds) of associated with familial adenomatous polyposis
15) Confidence 0.27 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.91 Pain Relevance 0
, the integrity of the tumor suppressor APC might be essential to guarantee PPAR?
APC Spec (might) Binding (integrity) of associated with cancer
16) Confidence 0.23 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 0.69 Pain Relevance 0.05
The binding of APC on endothelial and inflammatory cell receptors exerts pleiotropic in vitro intra- and intercellular effects, altering gene expression profiles, inhibiting apoptosis and down-regulating inflammation.
APC Binding (binding) of associated with inflammation and apoptosis
17) Confidence 0.22 Published 2010 Journal Crit Care Section Body Doc Link PMC2887172 Disease Relevance 1.38 Pain Relevance 0.13
CONCLUSIONS: According to the findings, APC may be associated with minor complications such as pain sensation and NMS.
APC Binding (associated) of
18) Confidence 0.21 Published 2008 Journal Surg Endosc Section Body Doc Link 18071803 Disease Relevance 0 Pain Relevance 0
In mice, APC crosses the blood-brain barrier via binding on the endothelial protein C receptor, acts directly on neurons, microglial cells, microvessels and motor neurons [25], and protects stressed brain endothelial cells from hypoxic/ischaemic damage [26].
APC Binding (binding) of in blood associated with hypoxia
19) Confidence 0.16 Published 2010 Journal Crit Care Section Body Doc Link PMC2887172 Disease Relevance 1.11 Pain Relevance 0.13
Regarding the first concept, it is important to point out that our assay of aPC, aPS, aPE and aCL does not identify the specific plasma antigen responsible for a positive test.
aPC Binding (assay) of in plasma
20) Confidence 0.16 Published 2007 Journal BMC Neurol Section Body Doc Link PMC2219992 Disease Relevance 0.94 Pain Relevance 0.40

General Comments

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