INT63132

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Context Info
Confidence 0.13
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.86
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
striatum 2
shoulder 1
DA neurons 1
Pd (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 6 100.00 Very High Very High Very High
Nerve growth factor 6 99.80 Very High Very High Very High
Dopamine 21 99.66 Very High Very High Very High
Dynorphin 12 98.88 Very High Very High Very High
cytokine 16 97.40 Very High Very High Very High
antagonist 6 95.92 Very High Very High Very High
Substantia nigra 6 93.52 High High
Nucleus accumbens 1 90.24 High High
withdrawal 27 82.16 Quite High
Nicotine 7 81.08 Quite High
Disease Link Frequency Relevance Heat
Panic Disorder 202 100.00 Very High Very High Very High
Disease 100 100.00 Very High Very High Very High
Apoptosis 8 99.84 Very High Very High Very High
Personality Disorder 12 99.40 Very High Very High Very High
Parkinson's Disease 22 96.48 Very High Very High Very High
Stroke 222 96.24 Very High Very High Very High
Fever 2 85.72 High High
Cancer 2 84.80 Quite High
Muscle Hypotonia 2 84.44 Quite High
Necrosis 2 84.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, 4 days of monocular deprivation were insufficient to induce a significant ocular dominance shift in both PD95 and PD130 animals.
Positive_regulation (induce) of PD130
1) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518841 Disease Relevance 0 Pain Relevance 0
Dyn was decreased in both ventral and dorsal striatum, and PD mRNA was differentially increased in the two striatal compartments as demonstrated by in situ hybridization.
Positive_regulation (increased) of PD mRNA in striatum associated with dynorphin
2) Confidence 0.06 Published 2008 Journal Synapse Section Abstract Doc Link 18361441 Disease Relevance 0.20 Pain Relevance 0.88
One hypothesis of the cause of degeneration of the nigrostriatal DA neurons is that PD is caused by programmed cell death (apoptosis) due to increased levels of cytokines and/or decreased ones of neurotrophins.
Positive_regulation (caused) of PD in DA neurons associated with dopamine, apoptosis, disease and cytokine
3) Confidence 0.05 Published 2000 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 11205147 Disease Relevance 0.89 Pain Relevance 0.45
In experimental animal models of PD, IL-1beta level was increased and NGF one decreased in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonian mice, and TNF-alpha level was increased in the substantia nigra and striatum of the 6-hydroxydopamine (6OHDA)-injected side of hemiparkinsonian rats.
Positive_regulation (increased) of PD in striatum associated with parkinson's disease, nerve growth factor, substantia nigra and disease
4) Confidence 0.04 Published 2000 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 11205147 Disease Relevance 1.28 Pain Relevance 0.60
In PD, input% increased with SE-resistance in healthy persons, whereas no significant change was detected in chronic stroke patients ('status × resistance' p = 0.011).
Positive_regulation (increased) of PD associated with stroke
5) Confidence 0.02 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2850340 Disease Relevance 0.78 Pain Relevance 0
In addition, it is likely that with SE-resistance more stabilization of the shoulder joint is needed to control the larger shoulder elevation forces, resulting in slightly increased activity levels of PD and LD.
Positive_regulation (increased) of PD in shoulder
6) Confidence 0.02 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2850340 Disease Relevance 0.69 Pain Relevance 0
During post-partum, the frequency of PD increases compared to pregnancy (1.4%–3.9% of women), and a worsening of pregravid symptom severity more likely occurs, as observed in 20%–63% of women or post-partum periods (Bandelow et al 2006; Ross and McLean 2006).
Positive_regulation (increases) of PD associated with panic disorder
7) Confidence 0.01 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515914 Disease Relevance 0.64 Pain Relevance 0.27
Moreover, psychological therapy is probably beneficial for symptom stabilization in PD patients with personality disorders or with extensive psychological conflicts (APA 1998; Mathew et al 2001).
Positive_regulation (stabilization) of PD associated with panic disorder and personality disorder
8) Confidence 0.01 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515914 Disease Relevance 0.47 Pain Relevance 0.17
Dopaminergic denervation with 6-hydroxydopamine (6OHDA) blocked the GBR-induced increases in SP and DYN and PPT and PD mRNAs.
Positive_regulation (increases) of PD associated with substance p
9) Confidence 0.01 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.74
The mean walking distance increased by 9.4% in the PD group and by 5.2% in the control group during the S-VS walking.
Positive_regulation (increased) of PD associated with disease
10) Confidence 0.01 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1471796 Disease Relevance 0.35 Pain Relevance 0.03
This pilot study assessed the effects of enhanced proprioceptive feedback using step-synchronized vibration stimulation of the soles (S-VS) on gait in PD.
Positive_regulation (stimulation) of PD associated with disease
11) Confidence 0.01 Published 2006 Journal J Neuroengineering Rehabil Section Abstract Doc Link PMC1471796 Disease Relevance 0.55 Pain Relevance 0

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