INT63135

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Context Info
Confidence 0.04
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 1.91
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
arm 1
striatum 1
Pd (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 24 99.06 Very High Very High Very High
Dopamine 28 98.32 Very High Very High Very High
antagonist 8 98.20 Very High Very High Very High
Dynorphin 20 95.84 Very High Very High Very High
Enkephalin 4 25.00 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 279 100.00 Very High Very High Very High
Tremor 3 94.80 High High
Cognitive Disorder 3 76.44 Quite High
Movement Disorders 6 49.52 Quite Low
Handedness 3 40.16 Quite Low
Neurological Disease 3 32.16 Quite Low
Aids-related Complex 6 5.00 Very Low Very Low Very Low
Focal Dystonia 3 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 3 5.00 Very Low Very Low Very Low
Motor Neuron Diseases 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sensitivity to concave curvature was normal in the PD patient group
Transcription (group) of PD associated with disease
1) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440419 Disease Relevance 0.47 Pain Relevance 0
The right arm was more affected than the left in each PD subject, and the right arm was tested in the PD group.
Transcription (tested) of PD in arm associated with disease
2) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440419 Disease Relevance 0.80 Pain Relevance 0
Sensitivity to convex curvature was lower in the PD patient group
Transcription (group) of PD associated with disease
3) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440419 Disease Relevance 0.64 Pain Relevance 0
The increased peptide levels were associated with increases in the abundance of PD mRNA and PPT mRNA and increases in the rate of transcription of PD and PPT genes in the striatum, suggesting a GBR-induced activation of the striatonigral tachykinin and dynorphin neurons.
Transcription (transcription) of PD in neurons associated with dynorphin
4) Confidence 0.02 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.67
The increased peptide levels were associated with increases in the abundance of PD mRNA and PPT mRNA and increases in the rate of transcription of PD and PPT genes in the striatum, suggesting a GBR-induced activation of the striatonigral tachykinin and dynorphin neurons.
Transcription (abundance) of PD in neurons associated with dynorphin
5) Confidence 0.02 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.66
The rate of transcription of PPT and PD genes in the striatum was measured by transcription run-on assays.
Transcription (transcription) of PD in striatum
6) Confidence 0.02 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.49
The concurrent administration of the D1 DA antagonist, SCH-23390, blocked the GBR-induced increases in SP, NKA and PPT mRNA but failed to affect DYN or PD mRNA levels; the concurrent administration of the D2 DA antagonist, spiperone, blocked the GBR-induced increases in SP, NKA and PPT mRNA and also DYN and PD mRNA.
Transcription (levels) of PD associated with dopamine, antagonist and substance p
7) Confidence 0.02 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.77

General Comments

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