INT63136

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Context Info
Confidence 0.02
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.34

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Anatomy Link Frequency
neurons 4
Pd (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 12 96.76 Very High Very High Very High
Dynorphin 10 95.84 Very High Very High Very High
Dopamine 14 76.88 Quite High
antagonist 4 76.64 Quite High
Enkephalin 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased peptide levels were associated with increases in the abundance of PD mRNA and PPT mRNA and increases in the rate of transcription of PD and PPT genes in the striatum, suggesting a GBR-induced activation of the striatonigral tachykinin and dynorphin neurons.
Positive_regulation (increases) of Transcription (transcription) of PD in neurons associated with dynorphin
1) Confidence 0.02 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.68
The increased peptide levels were associated with increases in the abundance of PD mRNA and PPT mRNA and increases in the rate of transcription of PD and PPT genes in the striatum, suggesting a GBR-induced activation of the striatonigral tachykinin and dynorphin neurons.
Positive_regulation (increases) of Transcription (abundance) of PD in neurons associated with dynorphin
2) Confidence 0.01 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.67

General Comments

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