INT63137

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Context Info
Confidence 0.12
First Reported 1996
Last Reported 2008
Negated 4
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.01
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
joint 2
limb 1
Pd (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 6 99.34 Very High Very High Very High
antagonist 4 98.30 Very High Very High Very High
Dopamine 7 98.08 Very High Very High Very High
Dynorphin 5 89.04 High High
depression 12 78.24 Quite High
imagery 30 49.28 Quite Low
gABA 1 27.52 Quite Low
Enkephalin 1 25.00 Low Low
Serotonin 2 24.64 Low Low
noradrenaline 1 21.68 Low Low
Disease Link Frequency Relevance Heat
Disease 394 100.00 Very High Very High Very High
Panic Disorder 101 100.00 Very High Very High Very High
Loss Of Sense Of Smell 4 96.12 Very High Very High Very High
Cognitive Disorder 10 94.44 High High
Recurrence 9 86.92 High High
Anxiety Disorder 20 80.00 Quite High
Depression 15 79.44 Quite High
Agoraphobia 3 79.28 Quite High
Fever 3 77.56 Quite High
Gastroenteritis 12 72.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, in all older age groups (PD130 and PD215), 7 or even 14 days of monocular deprivation had no significant effect on the ocular dominance and average ODIs were statistically indifferent from control values (Figs. 1f, h and 2).
Neg (no) Regulation (effect) of PD215
1) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518841 Disease Relevance 0 Pain Relevance 0
Control ODIs of PD95 and PD215 were not statistically different from any other group (p>0.2 in all comparisons).
Neg (not) Regulation (different) of PD215
2) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518841 Disease Relevance 0 Pain Relevance 0
Interestingly, in all older age groups (PD130 and PD215), 7 or even 14 days of monocular deprivation had no significant effect on the ocular dominance and average ODIs were statistically indifferent from control values (Figs. 1f, h and 2).
Neg (no) Regulation (effect) of PD130
3) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518841 Disease Relevance 0 Pain Relevance 0
Previous studies documented that limb position and passive motion sense are affected in PD at the level of a single joint [11], [13].
Regulation (affected) of PD in joint associated with disease
4) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440419 Disease Relevance 0.60 Pain Relevance 0
The component probabilities Pd and Ps were then calculated separately for each severity category as shown in Table 3.
Regulation (calculated) of Pd
5) Confidence 0.04 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2609882 Disease Relevance 0.27 Pain Relevance 0
Evidence that kinaesthesia is especially affected in PD comes from experiments showing that PD patients perform poorly in tasks requiring matching, estimation or memorization of joint positions [6]–[8].
Regulation (affected) of PD in joint associated with disease
6) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440419 Disease Relevance 1.05 Pain Relevance 0
b) Is curvature sensitivity differentially affected in PD during active versus passive limb motion?
Regulation (affected) of PD in limb associated with disease
7) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440419 Disease Relevance 0.52 Pain Relevance 0
In addition, demonstrating that curvature sensitivity is less affected in PD during active than passive motion would indicate that kinematic information derived from an efference copy of the underlying motor commands may be used to compensate for a loss in proprioceptive or tactile sensitivity.


Regulation (affected) of PD associated with disease
8) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440419 Disease Relevance 0.57 Pain Relevance 0
The concurrent administration of the D1 DA antagonist, SCH-23390, blocked the GBR-induced increases in SP, NKA and PPT mRNA but failed to affect DYN or PD mRNA levels; the concurrent administration of the D2 DA antagonist, spiperone, blocked the GBR-induced increases in SP, NKA and PPT mRNA and also DYN and PD mRNA.
Neg (failed) Regulation (affect) of PD associated with dopamine, antagonist and substance p
9) Confidence 0.01 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.77
These recommendations have recently been confirmed by a meta-analysis, comparing the efficacy of CBT, pharmacotherapy and placebo in PD (Mitte 2005).
Regulation (efficacy) of PD associated with panic disorder
10) Confidence 0.01 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515914 Disease Relevance 1.00 Pain Relevance 0.04

General Comments

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