INT63164

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 51
Total Number 54
Disease Relevance 18.48
Pain Relevance 20.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cst7)
Anatomy Link Frequency
muscle 8
nerve 7
sensory nerve 3
lower limbs 1
blood 1
Cst7 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 2400 100.00 Very High Very High Very High
carpal tunnel syndrome 455 99.84 Very High Very High Very High
tramadol 9 99.64 Very High Very High Very High
intrathecal 7 99.46 Very High Very High Very High
Botox 6 98.92 Very High Very High Very High
anesthesia 24 98.40 Very High Very High Very High
ischemia 76 98.14 Very High Very High Very High
Opioid 20 94.60 High High
rapifen 8 92.24 High High
Demyelination 18 90.88 High High
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 36 100.00 Very High Very High Very High
Muscle Disease 20 99.96 Very High Very High Very High
Carpal Tunnel Syndrome 488 99.84 Very High Very High Very High
Sepsis 456 99.60 Very High Very High Very High
Hypopituitarism 6 99.20 Very High Very High Very High
Injury 266 98.40 Very High Very High Very High
Cv Unclassified Under Development 99 98.14 Very High Very High Very High
Stroke 28 98.04 Very High Very High Very High
Myalgia 2 97.64 Very High Very High Very High
Cramps 2 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In studies that aimed to investigate the effects of ischemia on nerve action potential [16], CMAP [17], and evoked potential [18], it was found that 50% reduction in CMAP amplitude was sufficient to elicit a 20% reduction in nerve conduction velocity, which is again larger than seen in this study.
Negative_regulation (reduction) of CMAP in nerve associated with action potential and ischemia
1) Confidence 0.50 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0.40 Pain Relevance 0.66
For example, a 50% reduction in conduction velocity across the injured region would cause a 50% reduction in the CMAP conduction velocity if the entire nerve was involved.
Negative_regulation (reduction) of CMAP in nerve associated with action potential
2) Confidence 0.50 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0.53 Pain Relevance 0.48
Trains of spontaneous EMG activity are more commonly recorded when the CMAP amplitude is significantly reduced from baseline.
Negative_regulation (reduced) of CMAP associated with action potential
3) Confidence 0.50 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.40
The CMAP amplitude is reduced by 50% for the first time during compression at a tension T = 52.7 g (std 22.7, min 18, max 79) corresponding to a mean pressure of 970 mmHg.
Negative_regulation (reduced) of CMAP associated with action potential
4) Confidence 0.50 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.46
In order to determine if the degree of CMAP amplitude reduction during low level compression predicted the degree of CMAP reduction with higher level compression, a Spearman rank correlations is performed.
Negative_regulation (reduction) of CMAP associated with action potential
5) Confidence 0.50 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.47
There is also no significant correlation between the CMAP amplitude reduction during the 1st compression and CMAP amplitude reduction during the final recovery.
Negative_regulation (reduction) of CMAP associated with action potential
6) Confidence 0.37 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.41
The CMAP amplitude and AUC reductions first reach statistical significance during the phase in which the nerve is subjected to compression at a tension of 80 g.
Negative_regulation (reductions) of CMAP in nerve associated with action potential
7) Confidence 0.37 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.45
In order to determine if the degree of CMAP amplitude reduction during low level compression predicted the degree of CMAP reduction with higher level compression, a Spearman rank correlations is performed.
Negative_regulation (reduction) of CMAP associated with action potential
8) Confidence 0.37 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.44
On the other hand, ischemic and stretch injuries are associated with larger changes in conduction velocity for a given value of CMAP amplitude reduction.



Negative_regulation (reduction) of CMAP associated with action potential and injury
9) Confidence 0.37 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Abstract Doc Link PMC2245939 Disease Relevance 0.33 Pain Relevance 0.26
This study has demonstrated that the uniform response to mild to moderate hyperacute nerve compression over very short distances (1.3 mm) is characterized by marked reduction in the CMAP amplitude with relatively small but significant reductions in CMAP velocity.
Negative_regulation (reduction) of CMAP in nerve associated with action potential
10) Confidence 0.37 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.37
First, compression to 20 g of tension (P = 370 mmHg) leads to very little acute reduction in CMAP amplitude (~20%, figure 2A) while compression to 80 g (P = 1470 mmHg) causes significant CMAP amplitude reduction (~60%) but only minimal CMAP latency increases (figure 2B).
Negative_regulation (reduction) of CMAP associated with action potential
11) Confidence 0.37 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.43
This study has demonstrated that the uniform response to mild to moderate hyperacute nerve compression over very short distances (1.3 mm) is characterized by marked reduction in the CMAP amplitude with relatively small but significant reductions in CMAP velocity.
Negative_regulation (reductions) of CMAP in nerve associated with action potential
12) Confidence 0.37 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.35
Second, there is considerable variation in the CMAP duration but durations typically drop as the CMAP amplitude declines.
Negative_regulation (declines) of CMAP associated with action potential
13) Confidence 0.37 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.46
First, compression to 20 g of tension (P = 370 mmHg) leads to very little acute reduction in CMAP amplitude (~20%, figure 2A) while compression to 80 g (P = 1470 mmHg) causes significant CMAP amplitude reduction (~60%) but only minimal CMAP latency increases (figure 2B).
Neg (little) Negative_regulation (reduction) of CMAP associated with action potential
14) Confidence 0.37 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.41
There is also no significant correlation between the CMAP amplitude reduction during the 1st compression and CMAP amplitude reduction during the final recovery.
Negative_regulation (reduction) of CMAP associated with action potential
15) Confidence 0.37 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.40
Upon muscle lengthening with relaxation, both groups showed a reduction in CMAP amplitude and an increase in CMAP duration.
Negative_regulation (reduction) of CMAP in muscle
16) Confidence 0.37 Published 2005 Journal J Electromyogr Kinesiol Section Abstract Doc Link 15763674 Disease Relevance 0.55 Pain Relevance 0.62
A reduction in the compound muscle action potential (CMAP) amplitude of the abductor pollicis was noted after intracarpal pressure increased.
Negative_regulation (reduction) of CMAP in muscle associated with action potential
17) Confidence 0.37 Published 2002 Journal Muscle Nerve Section Abstract Doc Link 12210364 Disease Relevance 0.73 Pain Relevance 0.59
Decreasing CMAP on high frequency RNS suggested muscle membrane conduction anomalies and, though clinical and electrical myotonia was not detected, the neurophysiological finding raised the suspicion of congenital myotonia and addressed to molecular investigation.
Negative_regulation (Decreasing) of CMAP in muscle associated with action potential and hypopituitarism
18) Confidence 0.37 Published 2002 Journal Electromyogr Clin Neurophysiol Section Abstract Doc Link 12224470 Disease Relevance 0.71 Pain Relevance 0.17
In this myopathy, decreasing CMAP after exercise test and RNS are the most sensitive electrophysiological in detecting muscle membrane dysfunction and are considered highly informative even in mildly symptomatic patients.
Negative_regulation (decreasing) of CMAP in muscle associated with action potential and muscle disease
19) Confidence 0.37 Published 2002 Journal Electromyogr Clin Neurophysiol Section Abstract Doc Link 12224470 Disease Relevance 0.61 Pain Relevance 0.18
With increasing concentrations of desflurane, there was a progressive decrease in the CMAP amplitude and systemic blood pressure over the baseline values.
Negative_regulation (decrease) of CMAP in blood
20) Confidence 0.37 Published 1996 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 8719193 Disease Relevance 0.09 Pain Relevance 0.18

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