INT63169

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 21.95
Pain Relevance 7.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) cell adhesion (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
platelets 22
gut 8
joints 6
endothelial cell 4
endothelium 4
Selp (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 77 100.00 Very High Very High Very High
psoriasis 37 99.84 Very High Very High Very High
Pain 18 99.74 Very High Very High Very High
Arthritis 459 99.66 Very High Very High Very High
antinociception 9 99.60 Very High Very High Very High
Inflammatory mediators 22 99.52 Very High Very High Very High
chemokine 44 99.36 Very High Very High Very High
Inflammatory response 65 99.34 Very High Very High Very High
Angina 9 99.28 Very High Very High Very High
Inflammation 343 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 182 100.00 Very High Very High Very High
Atherosclerosis 53 100.00 Very High Very High Very High
Psoriasis 41 99.84 Very High Very High Very High
Arthritis 513 99.82 Very High Very High Very High
Pain 15 99.74 Very High Very High Very High
Sickle Cell Anemia 12 99.64 Very High Very High Very High
Endotoxemia 147 99.56 Very High Very High Very High
INFLAMMATION 399 99.52 Very High Very High Very High
Cv General 3 Under Development 82 99.28 Very High Very High Very High
Hypothermia 322 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found faster V(RBC) of sickle RBCs in P-selectin knock-out and control mice than in sickle cell mice, which have increased endothelial cell P-selectin expression.
Positive_regulation (increased) of Gene_expression (expression) of P-selectin in endothelial cell associated with sickle cell anemia and targeted disruption
1) Confidence 0.69 Published 2004 Journal Blood Section Abstract Doc Link 15271798 Disease Relevance 0.44 Pain Relevance 0.12
Incubation with TRAP significantly and maximally increased P-selectin and microparticle expression compared with baseline values of unstimulated platelets (Figures 1 and 2).
Positive_regulation (increased) of Gene_expression (expression) of P-selectin in platelets
2) Confidence 0.64 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.23 Pain Relevance 0.03
Thus, decreased baseline P-selectin expression observed in the second week does not appear to be induced by HES since patients required significantly less HES 130/0.4 compared with the first week.
Positive_regulation (induced) of Gene_expression (expression) of P-selectin
3) Confidence 0.64 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.37 Pain Relevance 0.07
In addition, norepinephrine stimulated the expression of surface P-selectin and intracellular prothrombotic microparticles.
Positive_regulation (stimulated) of Gene_expression (expression) of P-selectin
4) Confidence 0.56 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0 Pain Relevance 0.04
CD62p expression was also evaluated in 30 normal control subjects.
Positive_regulation (evaluated) of Gene_expression (expression) of CD62p
5) Confidence 0.50 Published 2005 Journal Circ. J. Section Body Doc Link 16195618 Disease Relevance 0.09 Pain Relevance 0
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Positive_regulation (increased) of Gene_expression (expression) of P-selectin
6) Confidence 0.49 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.59 Pain Relevance 0.53
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Positive_regulation (increased) of Gene_expression (expression) of P-selectin
7) Confidence 0.49 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.58 Pain Relevance 0.44
Increased expression of E-selectin and P-selectin has been observed in inflamed joints from RA patients, with several studies showing significant elevations in soluble selectins in the serum of patients with active disease [7-10].
Positive_regulation (Increased) of Gene_expression (expression) of P-selectin in joints associated with rheumatoid arthritis and disease
8) Confidence 0.47 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.20 Pain Relevance 0.46
Under in vitro conditions, incubating isolated platelets with norepinephrine significantly and concentration-dependently increased the expression of surface P-selectin and intracellular prothrombotic microparticles, reflecting increased platelet activation.
Positive_regulation (increased) of Gene_expression (expression) of P-selectin in platelet
9) Confidence 0.38 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.09 Pain Relevance 0
At present, it remains unclear whether the observed alterations are of clinical importance since only norepinephrine in high concentrations exceeding clinically relevant plasma levels (>25 nM) increased the expression of surface P-selectin and intracellular microparticles in isolated platelets.
Positive_regulation (increased) of Gene_expression (expression) of P-selectin in platelets
10) Confidence 0.38 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.33 Pain Relevance 0.13
L-selectin is expressed on the majority of leukocytes and is shed from the cell surface following activation, whereas P-selectin and E-selectin are expressed on endothelial cells following activation by various inflammatory mediators.
Positive_regulation (activation) of Gene_expression (expressed) of P-selectin in leukocytes associated with inflammatory mediators
11) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.51 Pain Relevance 0.11
These findings indicate that in early-onset arthritic joints, expression of E-selectin and P-selectin can significantly influence the production of IL-1?
Positive_regulation (influence) of Gene_expression (expression) of P-selectin in joints associated with arthritis
12) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.84 Pain Relevance 0.31
Our previous and current studies in the CIA model show that leukocyte rolling via E-selectin and P-selectin is not required for the initiation of arthritis, and that loss of one or both of these adhesion molecules significantly accelerates the development and severity of joint inflammation.
Neg (not) Positive_regulation (required) of Gene_expression (leukocyte) of P-selectin in joint associated with inflammation, adhesions and arthritis
13) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.28 Pain Relevance 0.55
In this study, we observed that, 18 h after administration, zymosan induced the expression of P-selectin in the endothelium of small vessels and upregulated the surface expression of ICAM-1 and P-Selectin on endothelial cells in the pancreas, lung and gut.
Positive_regulation (induced) of Gene_expression (expression) of P-selectin in gut
14) Confidence 0.34 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.60 Pain Relevance 0.20
Serum levels of soluble P-selectin, ICAM-1 and VCAM-1 are elevated in patients with angina pectoris or peripheral atherosclerotic disease.
Positive_regulation (elevated) of Gene_expression (levels) of P-selectin associated with angina, atherosclerosis and disease
15) Confidence 0.32 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.25 Pain Relevance 0.18
In platelets of saline controls (37°C), in vitro stimulation with thrombin resulted in elevated expression of P-selectin, GPIIb-IIIa and CD107a.
Positive_regulation (resulted) of Gene_expression (expression) of P-selectin in platelets
16) Confidence 0.31 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.33 Pain Relevance 0
The immediate inflammatory response and the stimulation by agonists induce endothelial cell expression of P-selectin.
Positive_regulation (induce) of Gene_expression (expression) of P-selectin in endothelial cell associated with inflammatory response and agonist
17) Confidence 0.31 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.65 Pain Relevance 0.19
By this we could show an increased expression of P-selectin in the microvascular endothelium during exdotoxemia, which may indicate that a significant proportion of the circulating sP-selectin originates from the activated endothelium.
Positive_regulation (increased) of Gene_expression (expression) of P-selectin in endothelium
18) Confidence 0.31 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.56 Pain Relevance 0.14
Endotoxemia resulted in a marked increase in the expression of P-selectin and PAI-1 within the microvascular endothelium.
Positive_regulation (increase) of Gene_expression (expression) of P-selectin in endothelium associated with endotoxemia
19) Confidence 0.31 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.45 Pain Relevance 0
In this study, we observed that, 18 h after administration, zymosan induced the expression of P-selectin in the endothelium of small vessels and upregulated the surface expression of ICAM-1 and P-Selectin on endothelial cells in the pancreas, lung and gut.
Positive_regulation (upregulated) of Gene_expression (expression) of P-Selectin in gut
20) Confidence 0.24 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.61 Pain Relevance 0.18

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