INT63170

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Context Info
Confidence 0.68
First Reported 1995
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 24.10
Pain Relevance 6.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) cell adhesion (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
platelet 10
blood 3
endothelial cells 2
monocyte 1
venules 1
Selp (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 1 100.00 Very High Very High Very High
cva 66 99.74 Very High Very High Very High
Pain 18 99.46 Very High Very High Very High
Angina 31 99.28 Very High Very High Very High
ischemia 133 99.24 Very High Very High Very High
cytokine 195 99.22 Very High Very High Very High
Arthritis 118 98.52 Very High Very High Very High
antinociception 9 97.76 Very High Very High Very High
Inflammatory mediators 26 93.68 High High
Inflammation 243 93.08 High High
Disease Link Frequency Relevance Heat
Adhesions 170 100.00 Very High Very High Very High
Cv General 3 Under Development 86 99.74 Very High Very High Very High
Endotoxemia 69 99.68 Very High Very High Very High
Pain 16 99.46 Very High Very High Very High
Myocardial Infarction 28 99.32 Very High Very High Very High
Atherosclerosis 20 99.30 Very High Very High Very High
Acute Coronary Syndrome 61 99.28 Very High Very High Very High
Cv Unclassified Under Development 87 99.24 Very High Very High Very High
Cancer 353 98.88 Very High Very High Very High
Arthritis 134 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Positive_regulation (increased) of P-selectin
1) Confidence 0.68 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.56 Pain Relevance 0.51
This, however, was not associated with an increase in jugular venous sP-selectin concentrations.
Positive_regulation (increase) of sP-selectin
2) Confidence 0.64 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.23 Pain Relevance 0.04
Due to the fact that the post-traumatic significantly increased sP-selectin levels exceeded normal values by several fold, any additional shedding might remain obscured.
Positive_regulation (increased) of sP-selectin
3) Confidence 0.64 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.42 Pain Relevance 0
Patients exhibited higher PMPs, increased platelet %CD62P, %CD63 and soluble P selectin (all P < 0.01) and hs-CRP (P = 0.0167) than healthy controls.
Positive_regulation (increased) of CD62P in platelet
4) Confidence 0.64 Published 2005 Journal Platelets Section Abstract Doc Link 16194867 Disease Relevance 0.95 Pain Relevance 0.20
Serum levels of soluble P-selectin, ICAM-1 and VCAM-1 are elevated in patients with angina pectoris or peripheral atherosclerotic disease.
Positive_regulation (elevated) of P-selectin associated with angina, atherosclerosis and disease
5) Confidence 0.48 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.25 Pain Relevance 0.18
In vitro stimulation of isolated platelets with norepinephrine showed a significant concentration-dependent increase in P-selectin-positive (Figure 1) and microparticle-positive (Figure 2) platelets compared with isolated platelets which were not stimulated by norepinephrine under baseline conditions.
Positive_regulation (increase) of P-selectin in platelets
6) Confidence 0.46 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.12 Pain Relevance 0
Peripheral blood was analysed for PMPs, percent platelets positive for CD62P and CD63 (all flow cytometry), soluble P selectin and hsCRP (both immunoassay).
Spec (analysed) Positive_regulation (positive) of CD62P in blood
7) Confidence 0.43 Published 2005 Journal Platelets Section Abstract Doc Link 16194867 Disease Relevance 0.96 Pain Relevance 0.21
Patients exhibited higher PMPs, increased platelet %CD62P, %CD63 and soluble P selectin (all P < 0.01) and hs-CRP (P = 0.0167) than healthy controls.
Positive_regulation (increased) of P selectin in platelet
8) Confidence 0.43 Published 2005 Journal Platelets Section Abstract Doc Link 16194867 Disease Relevance 0.95 Pain Relevance 0.20
Peripheral blood was analysed for PMPs, percent platelets positive for CD62P and CD63 (all flow cytometry), soluble P selectin and hsCRP (both immunoassay).
Spec (analysed) Positive_regulation (positive) of P selectin in blood
9) Confidence 0.43 Published 2005 Journal Platelets Section Abstract Doc Link 16194867 Disease Relevance 0.97 Pain Relevance 0.21
Studies of monocyte adhesion in isolated perfused carotid arteries harvested from atherosclerotic (apoE-/-) mice show a predominant involvement of P-selectin and its ligand P-selectin glycoprotein-1 (PSGL-1) in rolling and of VLA-4 and VCAM-1 in firm adhesion.
Positive_regulation (involvement) of P-selectin in monocyte associated with atherosclerosis and adhesions
10) Confidence 0.35 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.38 Pain Relevance 0.16
The severity of arthritis and the circulating levels of anti-type II collagen antibodies were also increased in P-selectin mutant mice.
Positive_regulation (increased) of P-selectin associated with arthritis
11) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.34 Pain Relevance 0.68
For example, in the cremaster muscle preparation, the abundant rolling leukocytes in the venules are due to P-selectin upregulation on endothelial cells in response to surgical trauma [25].
Positive_regulation (upregulation) of P-selectin in venules associated with injury
12) Confidence 0.31 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165062 Disease Relevance 0.57 Pain Relevance 0.32
Because P-selectin shed from platelets serves as the main source for circulating P-selectin and platelet activation results in up to 50% secretion of intracellular P-selectin [23], it is reasonable to assume that a major part of the increase in sP-selectin during endotoxemia might also be due to platelet activation.
Positive_regulation (increase) of sP-selectin in platelet associated with endotoxemia
13) Confidence 0.27 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.63 Pain Relevance 0.08
Renal ischemia has been shown to be associated with upregulation of endothelial P-selectin but not L-selectin, with enhanced adhesion of neutrophils [75].
Positive_regulation (upregulation) of P-selectin in neutrophils associated with ischemia and adhesions
14) Confidence 0.23 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.72 Pain Relevance 0.36
In addition, hypothermic temperatures were found associated with increased P-selectin shedding, although cardiopulmonary bypass patients did not reveal differences in circulating levels of ICAM-1 and VCAM-1 during normothermia and hypothermia [20].
Positive_regulation (increased) of P-selectin associated with hypothermia
15) Confidence 0.21 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.88 Pain Relevance 0.13
In parallel, endotoxemia in 37°C animals induced a marked increase of sP-selectin, sE-selectin, sICAM-1 and sVCAM-1 when compared to 37°C saline controls (Figure 3).
Positive_regulation (increase) of sP-selectin associated with endotoxemia
16) Confidence 0.18 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.77 Pain Relevance 0
We found prominent induction of ICAM-1 and to a lesser degree of VCAM-1 (Figs. 4, 5, 6), but not of mucosal addressin cell adhesion molecule (MAdCAM)-1, E-selectin or P-selectin (Table 1) on CVO microvessels during EAE.
Positive_regulation (induction) of P-selectin associated with multiple sclerosis and adhesions
17) Confidence 0.14 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.90 Pain Relevance 0.04
Due to preformed pools of P-selectin in endothelial cells and platelets, P-selectin can be upregulated quickly and faster than E-selectin after stroke [26,115].
Positive_regulation (upregulated) of P-selectin in endothelial cells associated with stroke
18) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.33 Pain Relevance 0.09
E-selectin is produced by stimulated endothelium and leukocytes and P-selectin also by platelets, hence the name.
Positive_regulation (stimulated) of P-selectin in platelets
19) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.56 Pain Relevance 0.12
Flow cytometric analysis demonstrated that the transcardiac gradient (the value of coronary sinus blood minus the value of peripheral blood) of platelet surface expression of CD62P (p < 0.001) and CD63 (p < 0.01) increased immediately after coronary stenting, but increased less significantly immediately after balloon angioplasty (CD62P, p < 0.01; CD63, p < 0.05).
Positive_regulation (increased) of CD62P in blood
20) Confidence 0.08 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 11074199 Disease Relevance 0.16 Pain Relevance 0.07

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